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7MF3
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BU of 7mf3 by Molmil
Structure of the autoinhibited state of smooth muscle myosin-2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light polypeptide 6, ...
Authors:Heissler, S.M, Arora, A.S, Billington, N, Sellers, J.R, Chinthalapudi, K.
Deposit date:2021-04-08
Release date:2022-01-05
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the autoinhibited state of myosin-2.
Sci Adv, 7, 2021
1BR2
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BU of 1br2 by Molmil
SMOOTH MUSCLE MYOSIN MOTOR DOMAIN COMPLEXED WITH MGADP.ALF4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN, ...
Authors:Dominguez, R, Trybus, K.M, Cohen, C.
Deposit date:1998-08-26
Release date:1998-09-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.
Cell(Cambridge,Mass.), 94, 1998
8ACT
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BU of 8act by Molmil
structure of the human beta-cardiac myosin folded-back off state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light chain 3, ...
Authors:Grinzato, A, Kandiah, E, Robert-Paganin, J, Auguin, D, Kikuti, C, Nandwani, N, Moussaoui, D, Pathak, D, Ruppel, K.M, Spudich, J.A, Houdusse, A.
Deposit date:2022-07-06
Release date:2023-06-07
Last modified:2023-08-30
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the folded-back state of human beta-cardiac myosin.
Nat Commun, 14, 2023
3MYK
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BU of 3myk by Molmil
Insights into the Importance of Hydrogen Bonding in the Gamma-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Ser236
Descriptor: (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, MAGNESIUM ION, Myosin-2 heavy chain, ...
Authors:Frye, J.J, Klenchin, V.A, Bagshaw, C.R, Rayment, I.
Deposit date:2010-05-10
Release date:2010-05-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Insights into the importance of hydrogen bonding in the gamma-phosphate binding pocket of myosin: structural and functional studies of serine 236
Biochemistry, 49, 2010
1BR4
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BU of 1br4 by Molmil
SMOOTH MUSCLE MYOSIN MOTOR DOMAIN-ESSENTIAL LIGHT CHAIN COMPLEX WITH MGADP.BEF3 BOUND AT THE ACTIVE SITE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Dominguez, R, Trybus, K.M, Cohen, C.
Deposit date:1998-08-27
Release date:1998-09-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.
Cell(Cambridge,Mass.), 94, 1998
5N6A
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BU of 5n6a by Molmil
Cardiac muscle myosin motor domain in the pre-powerstroke state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A.
Deposit date:2017-02-14
Release date:2017-08-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
Nat Commun, 8, 2017
2OTG
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BU of 2otg by Molmil
Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ...
Authors:Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C.
Deposit date:2007-02-08
Release date:2007-05-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor.
Structure, 15, 2007
2MYS
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BU of 2mys by Molmil
MYOSIN SUBFRAGMENT-1, ALPHA CARBON COORDINATES ONLY FOR THE TWO LIGHT CHAINS
Descriptor: MAGNESIUM ION, MYOSIN, SULFATE ION
Authors:Rayment, I, Holden, H.M.
Deposit date:1996-06-27
Release date:1997-01-11
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of myosin subfragment-1: a molecular motor.
Science, 261, 1993
3DTP
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BU of 3dtp by Molmil
Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick filament Cryo-EM 3D-MAP
Descriptor: Myosin II regulatory light chain, Myosin light polypeptide 6, Myosin-11,Myosin-7
Authors:Alamo, L, Wriggers, W, Pinto, A, Bartoli, F, Salazar, L, Zhao, F.Q, Craig, R, Padron, R.
Deposit date:2008-07-15
Release date:2008-10-07
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity
J.Mol.Biol., 384, 2008
2OS8
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BU of 2os8 by Molmil
Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor
Descriptor: CALCIUM ION, MAGNESIUM ION, Myosin essential light chain, ...
Authors:Yang, Y, Gourinath, S, Cohen, C, Brown, J.H.
Deposit date:2007-02-05
Release date:2007-05-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor.
Structure, 15, 2007
3MYH
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BU of 3myh by Molmil
Insights into the Importance of Hydrogen Bonding in the Gamma-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Ser236
Descriptor: (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Frye, J.J, Klenchin, V.A, Bagshaw, C.R, Rayment, I.
Deposit date:2010-05-10
Release date:2010-05-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Insights into the importance of hydrogen bonding in the gamma-phosphate binding pocket of myosin: structural and functional studies of serine 236
Biochemistry, 49, 2010
3MYL
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BU of 3myl by Molmil
Insights into the Importance of Hydrogen Bonding in the Gamma-Phosphate Binding Pocket of Myosin: Structural and Functional Studies of Ser236
Descriptor: MAGNESIUM ION, Myosin-2 heavy chain, PYROPHOSPHATE 2-
Authors:Frye, J.J, Klenchin, V.A, Bagshaw, C.R, Rayment, I.
Deposit date:2010-05-10
Release date:2010-05-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into the importance of hydrogen bonding in the gamma-phosphate binding pocket of myosin: structural and functional studies of serine 236
Biochemistry, 49, 2010
2Y8I
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BU of 2y8i by Molmil
Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN
Authors:Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J.
Deposit date:2011-02-07
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.132 Å)
Cite:Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
3L9I
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BU of 3l9i by Molmil
Myosin VI nucleotide-free (mdinsert2) L310G mutant crystal structure
Descriptor: ACETATE ION, CALCIUM ION, Calmodulin, ...
Authors:Pylypenko, O, Song, L, Sweeney, L.H, Houdusse, A.
Deposit date:2010-01-05
Release date:2010-12-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Role of insert i of myosin VI in modulating nucleotide affinity
To be Published
3MNQ
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BU of 3mnq by Molmil
Crystal structure of myosin-2 motor domain in complex with ADP-metavanadate and resveratrol
Descriptor: 1,2-ETHANEDIOL, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Schneider, J, Taft, M, Backhaus, A, Baruch, P, Fedorov, R, Manstein, D.J.
Deposit date:2010-04-22
Release date:2011-04-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of resveratrol regulation of myosin activity.
To be Published
3MKD
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BU of 3mkd by Molmil
Crystal structure of myosin-2 dictyostelium discoideum motor domain S456Y mutant in complex with adp-orthovanadate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-2 heavy chain, ...
Authors:Kathmann, D, Diensthuber, R.P, Fedorov, R, Manstein, D.J, Tsiavaliaris, G.
Deposit date:2010-04-14
Release date:2011-04-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Switch-2 dependent modulation of the myosin power stroke
To be Published
2Y9E
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BU of 2y9e by Molmil
Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2
Descriptor: MYOSIN-2
Authors:Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J.
Deposit date:2011-02-14
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.397 Å)
Cite:Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
2Y0R
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BU of 2y0r by Molmil
Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2
Descriptor: MYOSIN-2 HEAVY CHAIN
Authors:Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J.
Deposit date:2010-12-07
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
3MJX
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BU of 3mjx by Molmil
Crystal structure of myosin-2 motor domain in complex with ADP-Metavanadate and blebbistatin
Descriptor: (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, ADP METAVANADATE, MAGNESIUM ION, ...
Authors:Fedorov, R, Baruch, P, Bauer, S, Manstein, D.J.
Deposit date:2010-04-13
Release date:2011-04-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The mechanism of pentabromopseudilin inhibition of myosin motor activity.
Nat.Struct.Mol.Biol., 16, 2009
3BZ9
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BU of 3bz9 by Molmil
Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II
Descriptor: (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Allingham, J.S, Rayment, I.
Deposit date:2008-01-17
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Org.Biomol.Chem., 6, 2008
2BKI
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BU of 2bki by Molmil
Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure
Descriptor: CALCIUM ION, CALMODULIN, SULFATE ION, ...
Authors:Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A.
Deposit date:2005-02-16
Release date:2005-06-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal
Nature, 435, 2005
2EC6
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BU of 2ec6 by Molmil
Placopecten Striated Muscle Myosin II
Descriptor: CALCIUM ION, Myosin essential light chain, Myosin heavy chain, ...
Authors:Yang, Y, Brown, J, Samudrala, G, Reutzel, R, Szent-Gyorgyi, A.
Deposit date:2007-02-10
Release date:2008-02-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor.
Structure, 15, 2007
2BKH
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BU of 2bkh by Molmil
Myosin VI nucleotide-free (MDInsert2) crystal structure
Descriptor: CALCIUM ION, CALMODULIN, GLYCEROL, ...
Authors:Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A.
Deposit date:2005-02-16
Release date:2005-06-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal
Nature, 435, 2005
8QYQ
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BU of 8qyq by Molmil
Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Mavacamten
Descriptor: 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A.
Deposit date:2023-10-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
Biorxiv, 2023
8QYP
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BU of 8qyp by Molmil
Beta-cardiac myosin motor domain in the pre-powerstroke state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-7, ...
Authors:Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A.
Deposit date:2023-10-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.759 Å)
Cite:Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
Biorxiv, 2023

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