1XEZ
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3ANZ
| Crystal Structure of alpha-hemolysin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, Alpha-hemolysin | Authors: | Yamashita, K, Kawauchi, H, Tanaka, Y, Yao, M, Tanaka, I. | Deposit date: | 2010-09-16 | Release date: | 2011-06-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | 2-Methyl-2,4-pentanediol induces spontaneous assembly of staphylococcal alpha-hemolysin into heptameric pore structure Protein Sci., 20, 2011
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6U49
| Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-23 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
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2YGT
| Clostridium perfringens delta-toxin | Descriptor: | DELTA TOXIN, GLYCEROL, IMIDAZOLE, ... | Authors: | Huyet, J, Naylor, C.E, Gibert, M, Popoff, M.R, Basak, A.K. | Deposit date: | 2011-04-20 | Release date: | 2012-05-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Insights Into Clostridium Perfringens Delta Toxin Pore Formation. Plos One, 8, 2013
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4P1X
| Crystal structure of staphylococcal LUK prepore | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Gamma-hemolysin component B, Gamma-hemolysin component C | Authors: | Yamashita, D, Tanaka, Y, Tanaka, I, Yao, M. | Deposit date: | 2014-02-28 | Release date: | 2014-10-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular basis of transmembrane beta-barrel formation of staphylococcal pore-forming toxins. Nat Commun, 5, 2014
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2QK7
| A covalent S-F heterodimer of staphylococcal gamma-hemolysin | Descriptor: | Gamma-hemolysin component A, Gamma-hemolysin component B | Authors: | Roblin, P, Guillet, V, Maveyraud, L, Mourey, L. | Deposit date: | 2007-07-10 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A covalent S-F heterodimer of leucotoxin reveals molecular plasticity of beta-barrel pore-forming toxins. Proteins, 71, 2008
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6U4P
| Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-26 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
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3B07
| Crystal structure of octameric pore form of gamma-hemolysin from Staphylococcus aureus | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Gamma-hemolysin component A, Gamma-hemolysin component B | Authors: | Yamashita, K, Kawai, Y, Tanaka, Y, Yao, M, Tanaka, I. | Deposit date: | 2011-06-06 | Release date: | 2011-10-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.495 Å) | Cite: | Crystal structure of the octameric pore of
staphylococcal gamma-hemolysin reveals the beta-barrel
pore formation mechanism by two components Proc.Natl.Acad.Sci.USA, 108, 2011
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2LKF
| LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS | Descriptor: | LEUKOCIDIN F SUBUNIT | Authors: | Olson, R, Nariya, H, Yokota, K, Kamio, Y, Gouaux, J.E. | Deposit date: | 1998-07-28 | Release date: | 1999-07-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel. Nat.Struct.Biol., 6, 1999
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4J0O
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4U6V
| Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody | Descriptor: | Alpha-hemolysin, Fab, antigen binding fragment, ... | Authors: | Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2014-07-29 | Release date: | 2014-09-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody. J.Biol.Chem., 289, 2014
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4IYC
| Structure of the T244A mutant of the PANTON-VALENTINE LEUCOCIDIN component from STAPHYLOCOCCUS AUREUS | Descriptor: | LukS-PV | Authors: | Maveyraud, L, Guerin, F, Lavnetie, B.J, Prevost, G, Mourey, L. | Deposit date: | 2013-01-28 | Release date: | 2014-01-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Residues essential for panton-valentine leukocidin s component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface Plos One, 9, 2014
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6RHW
| Crystal structure of human CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH | Descriptor: | Beta-channel forming cytolysin, DIMETHYL SULFOXIDE, Integrin alpha-M, ... | Authors: | Trstenjak, N, Milic, D, Djinovic-Carugo, K, Badarau, A. | Deposit date: | 2019-04-23 | Release date: | 2019-12-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity. Proc.Natl.Acad.Sci.USA, 117, 2020
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6U3T
| Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-22 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
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4IZL
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4YHD
| Staphylococcal alpha-hemolysin H35A mutant monomer | Descriptor: | Alpha-hemolysin, CHLORIDE ION | Authors: | Sugawara, T, Kato, K, Tanaka, Y, Yao, M. | Deposit date: | 2015-02-27 | Release date: | 2015-10-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Structural basis for pore-forming mechanism of staphylococcal alpha-hemolysin Toxicon, 108, 2015
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5K59
| Crystal structure of LukGH from Staphylococcus aureus in complex with a neutralising antibody | Descriptor: | CHLORIDE ION, Fab heavy chain, Fab light chain, ... | Authors: | Welin, M, Logan, D.T, Badarau, A, Mirkina, I, Zauner, G, Dolezilkova, I, Nagy, E. | Deposit date: | 2016-05-23 | Release date: | 2016-08-10 | Last modified: | 2018-01-17 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies. Mabs, 8, 2016
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3O44
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4P1Y
| Crystal structure of staphylococcal gamma-hemolysin prepore | Descriptor: | Gamma-hemolysin component A, Gamma-hemolysin component B | Authors: | Yamashita, D, Tanaka, Y, Tanaka, I, Yao, M. | Deposit date: | 2014-02-28 | Release date: | 2014-10-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.992 Å) | Cite: | Molecular basis of transmembrane beta-barrel formation of staphylococcal pore-forming toxins. Nat Commun, 5, 2014
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7T87
| CRYSTAL STRUCTURE OF LEUKOCIDIN AB/CENTYRIN S17/FAB 214F COMPLEX | Descriptor: | Antibody Fab B214 Heavy Chain, Antibody Fab B214 Light Chain, Centyrin S17, ... | Authors: | Luo, J, Malia, T.J, Buckley, P.T. | Deposit date: | 2021-12-15 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections. Cell Host Microbe, 31, 2023
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4P24
| pore forming toxin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-hemolysin | Authors: | Sugawara, T, Yamashita, D, Tanaka, Y, Tanaka, I, Yao, M. | Deposit date: | 2014-03-01 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for pore-forming mechanism of staphylococcal alpha-hemolysin. Toxicon, 108, 2015
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3ROH
| Crystal Structure of Leukotoxin (LukE) from Staphylococcus aureus subsp. aureus COL. | Descriptor: | CHLORIDE ION, Leucotoxin LukEv, TRIETHYLENE GLYCOL | Authors: | Minasov, G, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Bagnoli, F, Falugi, F, Bottomley, M, Grandi, G, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2011-04-25 | Release date: | 2011-05-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structures of the components of the Staphylococcus aureus leukotoxin ED. Acta Crystallogr.,Sect.D, 72, 2016
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4IDJ
| S.Aureus a-hemolysin monomer in complex with Fab | Descriptor: | Alpha-hemolysin, Fab Heavy chain, Fab Light chain, ... | Authors: | Strop, P. | Deposit date: | 2012-12-12 | Release date: | 2013-06-26 | Last modified: | 2021-05-26 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus alpha-Hemolysin. J.Mol.Biol., 425, 2013
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7O1Q
| Amyloid beta oligomer displayed on the alpha hemolysin scaffold | Descriptor: | Alpha-hemolysin hybridized Abeta | Authors: | Wu, J, Blum, T.B, Farrell, D.P, DiMaio, F, Abrahams, J.P, Luo, J. | Deposit date: | 2021-03-30 | Release date: | 2021-04-14 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-electron Microscopy Imaging of Alzheimer's Amyloid-beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold. Angew.Chem.Int.Ed.Engl., 60, 2021
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8GZ7
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