PDB: 438 resultsInfo pagesStatus searchChemie searchBIRD

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2R34	Crystal structure of MN human arg-insulin Descriptor: CHLORIDE ION, Insulin, MANGANESE (II) ION Authors: Sreekanth, R, Pattabhi, V, Rajan, S.S. Deposit date: 2007-08-29 Release date: 2008-09-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Metal induced structural changes observed in hexameric insulin Int.J.Biol.Macromol., 44, 2009
1FU2	FIRST PROTEIN STRUCTURE DETERMINED FROM X-RAY POWDER DIFFRACTION DATA Descriptor: CHLORIDE ION, INSULIN, A CHAIN, ... Authors: Von Dreele, R.B, Stephens, P.W, Blessing, R.H, Smith, G.D. Deposit date: 2000-09-13 Release date: 2000-10-16 Last modified: 2018-10-03 Method: POWDER DIFFRACTION Cite: The first protein crystal structure determined from high-resolution X-ray powder diffraction data: a variant of T3R3 human insulin-zinc complex produced by grinding. Acta Crystallogr.,Sect.D, 56, 2000
1G7A	1.2 A structure of T3R3 human insulin at 100 K Descriptor: ACETONE, CHLORIDE ION, GLYCEROL, ... Authors: Smith, G.D, Pangborn, W.A, Blessing, R.H. Deposit date: 2000-11-09 Release date: 2001-08-03 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced? Acta Crystallogr.,Sect.D, 57, 2001
1EV6	Structure of the monoclinic form of the M-cresol/insulin R6 hexamer Descriptor: CHLORIDE ION, INSULIN, M-CRESOL, ... Authors: Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. Deposit date: 2000-04-19 Release date: 2000-12-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol Biochem.Biophys.Res.Commun., 56, 2000
2WS1	Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form Descriptor: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN Authors: Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. Deposit date: 2009-09-03 Release date: 2010-02-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
1EFE	AN ACTIVE MINI-PROINSULIN, M2PI Descriptor: MINI-PROINSULIN Authors: Cho, Y, Chang, S.G, Choi, K.D, Shin, H, Ahn, B, Kim, K.S. Deposit date: 2000-02-08 Release date: 2000-03-17 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Solution Structure of an Active Mini-Proinsulin, M2PI: Inter-chain Flexibility is Crucial for Insulin Activity J.Biochem.Mol.Biol., 33, 2000
2WS6	Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form Descriptor: CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... Authors: Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. Deposit date: 2009-09-03 Release date: 2010-02-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
1EVR	The structure of the resorcinol/insulin R6 hexamer Descriptor: CHLORIDE ION, INSULIN, RESORCINOL, ... Authors: Smith, G.D, Ciszak, E, Magrum, L.A, Pangborn, W.A, Blessing, R.H. Deposit date: 2000-04-20 Release date: 2000-12-04 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: R6 hexameric insulin complexed with m-cresol or resorcinol. Acta Crystallogr.,Sect.D, 56, 2000
2WS0	Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5 Descriptor: INSULIN A CHAIN, INSULIN B CHAIN Authors: Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. Deposit date: 2009-09-03 Release date: 2010-02-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
1GZY	Human Insulin-like growth factor; In-house data Descriptor: INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE Authors: Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z. Deposit date: 2002-06-10 Release date: 2002-07-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin Biochemistry, 41, 2002
1GUJ	Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation. Descriptor: INSULIN, SULFATE ION Authors: Whittingham, J.L, Scott, D.J, Chance, K, Wilson, A, Finch, J, Brange, J, Dodson, G.G. Deposit date: 2002-01-28 Release date: 2002-03-08 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Insulin at Ph2: Structural Analysis of the Conditions Promoting Insulin Fibre Formation J.Mol.Biol., 318, 2002
1GZZ	Human Insulin-like growth factor; Hamburg data Descriptor: INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE Authors: Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z. Deposit date: 2002-06-10 Release date: 2002-07-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin Biochemistry, 41, 2002
1GZR	Human Insulin-like growth factor; ESRF data Descriptor: INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE Authors: Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z. Deposit date: 2002-05-28 Release date: 2002-07-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin Biochemistry, 41, 2002
5UQA	Insulin with proline analog FzP at position B28 in the R6 state Descriptor: ACETONE, CHLORIDE ION, GLYCEROL, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-07 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.31000245 Å) Cite: Insulin with proline analog FzP at position B28 in the R6 state To Be Published
5USP	Insulin with proline analog Pip at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.174 Å) Cite: Insulin with proline analog Pip at position B28 in the T2 state To Be Published
5USS	Insulin with proline analog PiP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.061 Å) Cite: Insulin with proline analog PiP at position B28 in the R6 state To Be Published
5UU2	Insulin with proline analog ThioP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-15 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.223 Å) Cite: Insulin with proline analog ThioP at position B28 in the T2 state To Be Published
5UU4	Insulin with proline analog ThioP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A Chain, Insulin B Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-16 Release date: 2018-02-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.973 Å) Cite: Insulin with proline analog ThioP at position B28 in the R6 state To Be Published
5URU	Insulin with proline analog DhP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin Chain A, Insulin Chain B, ... Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-13 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Insulin with proline analog DhP at position B28 in the R6 state To Be Published
5VIZ	X-Ray structure of Insulin Glargine Descriptor: Insulin, chain alpha, chain beta Authors: Reyes-Grajeda, J.P, Romero, A. Deposit date: 2017-04-17 Release date: 2017-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: X-Ray structure of Insulin Glargine To Be Published
5WDM	An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein Descriptor: Single-chain insulin analog Authors: Yee, V.C, Aldabbagh, K, Peng, Y. Deposit date: 2017-07-05 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.803 Å) Cite: An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293, 2018
5USV	Insulin with proline analog AzeP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-14 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Insulin with proline analog AzeP at position B28 in the T2 state To Be Published
5UOZ	Insulin with proline analog FyP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-01 Release date: 2018-02-07 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.17463875 Å) Cite: Insulin with proline analog FyP at position B28 in the T2 state To Be Published
5URT	Insulin with proline analog DhP at position B28 in the T2 state Descriptor: Insulin Chain A, Insulin Chain B, SODIUM ION Authors: Lieblich, S.A, Fang, K.Y, Tirrell, D.A. Deposit date: 2017-02-12 Release date: 2018-02-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.18 Å) Cite: Insulin with proline analog DhP at position B28 in the T2 state To Be Published
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING Descriptor: Insulin Authors: Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. Deposit date: 2017-06-29 Release date: 2017-11-15 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018

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