Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1GWZ
DownloadVisualize
BU of 1gwz by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1
Descriptor: SHP-1
Authors:Yang, J, Liang, X, Niu, T, Meng, W, Zhao, Z, Zhou, G.W.
Deposit date:1998-08-22
Release date:1999-08-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 273, 1998
4Y14
DownloadVisualize
BU of 4y14 by Molmil
Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ...
Authors:Choy, M.S, Connors, C, Page, R, Peti, W.
Deposit date:2015-02-06
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
J.Clin.Invest., 125, 2015
2A3K
DownloadVisualize
BU of 2a3k by Molmil
Crystal Structure of the Human Protein Tyrosine Phosphatase, PTPN7 (HePTP, Hematopoietic Protein Tyrosine Phosphatase)
Descriptor: PHOSPHATE ION, protein tyrosine phosphatase, non-receptor type 7, ...
Authors:Barr, A, Turnbull, A.P, Das, S, Eswaran, J, Debreczeni, J.E, Longmann, E, Smee, C, Burgess, N, Gileadi, O, Sundstrom, M, Arrowsmith, C, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2005-06-24
Release date:2005-07-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
3S3H
DownloadVisualize
BU of 3s3h by Molmil
Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a phosphopeptide substrate GP4
Descriptor: 1,4-BUTANEDIOL, 1-BUTANOL, Tyrosine-protein phosphatase 10D, ...
Authors:Madan, L.L, Gopal, B.
Deposit date:2011-05-18
Release date:2011-11-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
Biochemistry, 50, 2011
2Y2F
DownloadVisualize
BU of 2y2f by Molmil
Crystal structure of Yersinia pestis YopH in complex with an aminooxy- containing platform compound for inhibitor design
Descriptor: PROTEIN-TYROSINE PHOSPHATASE YOPH, [4-[3-(DIFLUORO-PHOSPHONO-METHYL)PHENYL]PHENYL]METHOXYAZANIUM
Authors:Lountos, G.T, Bahta, M, Dyas, B, Ulrich, R.G, Waugh, D.S, Burke, T.R.
Deposit date:2010-12-14
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia Pestis Outer Protein H (Yoph) Phosphatase.
J.Med.Chem., 54, 2011
7S4F
DownloadVisualize
BU of 7s4f by Molmil
Protein Tyrosine Phosphatase 1B - F182Q mutant bound with Hepes
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ...
Authors:Brandao, T.A.S, Hengge, A.C, Johnson, S.J.
Deposit date:2021-09-08
Release date:2022-09-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
7TVJ
DownloadVisualize
BU of 7tvj by Molmil
Crystal Structure of Monobody Mb(SHP2PTP_13)/SHP2 PTP Domain Complex
Descriptor: CITRATE ANION, Mb(SHP2PTP_13), Tyrosine-protein phosphatase non-receptor type 11
Authors:Sha, F, Koide, S.
Deposit date:2022-02-05
Release date:2023-02-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation.
J.Mol.Biol., 435, 2023
8DU7
DownloadVisualize
BU of 8du7 by Molmil
Room-temperature serial synchrotron crystallography (SSX) structure of apo PTP1B
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Ebrahim, A, Sharma, S, Keedy, D.A.
Deposit date:2022-07-27
Release date:2022-08-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B.
Acta Crystallogr.,Sect.F, 79, 2023
6ZZ4
DownloadVisualize
BU of 6zz4 by Molmil
Crystal structure of the PTPN2 C216G mutant
Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 2
Authors:Mechaly, A.E, Berthelet, J, Nian, Q, Parlato, M, Cerf-Bensussan, N, Haouz, A, Rodrigues-Lima, F.
Deposit date:2020-08-03
Release date:2021-08-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Protein Sci., 31, 2022
6H8S
DownloadVisualize
BU of 6h8s by Molmil
CRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-0314
Descriptor: 1-[3-piperidin-4-yl-5-(trifluoromethyl)phenyl]guanidine, Tyrosine-protein phosphatase non-receptor type 5
Authors:Fiegen, D, Schnapp, G.
Deposit date:2018-08-03
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.771 Å)
Cite:Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.
J. Med. Chem., 62, 2019
3MOW
DownloadVisualize
BU of 3mow by Molmil
Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
Descriptor: (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, Tyrosine-protein phosphatase non-receptor type 11
Authors:Zhang, Z.-Y, Liu, S, Yu, Z, Yu, X.
Deposit date:2010-04-23
Release date:2011-05-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
To be Published
3M4U
DownloadVisualize
BU of 3m4u by Molmil
Crystal Structure of Trypanosoma brucei Protein Tyrosine Phosphatase TbPTP1
Descriptor: PHOSPHATE ION, Tyrosine specific protein phosphatase, putative
Authors:Chou, S, Alber, T, Grundner, C.
Deposit date:2010-03-12
Release date:2010-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.392 Å)
Cite:The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46.
J.Biol.Chem., 285, 2010
6H8R
DownloadVisualize
BU of 6h8r by Molmil
CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND 2
Descriptor: 3-[(2~{S})-2-azanylpropyl]-5-(trifluoromethyl)phenol, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5
Authors:Hoerer, S, Fiegen, D, Schnapp, G.
Deposit date:2018-08-03
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.
J. Med. Chem., 62, 2019
6PFW
DownloadVisualize
BU of 6pfw by Molmil
Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, apo state
Descriptor: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-22
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PG0
DownloadVisualize
BU of 6pg0 by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P188A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-23
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PM8
DownloadVisualize
BU of 6pm8 by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-07-01
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PGT
DownloadVisualize
BU of 6pgt by Molmil
Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-24
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PHA
DownloadVisualize
BU of 6pha by Molmil
Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, vanadate bound state
Descriptor: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ...
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-25
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
6PHS
DownloadVisualize
BU of 6phs by Molmil
Protein Tyrosine Phosphatase 1B (1-301), P185A mutant, vanadate bound state
Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION
Authors:Cui, D.S, Lipchock, J.M, Loria, J.P.
Deposit date:2019-06-25
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.129 Å)
Cite:Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
5OVR
DownloadVisualize
BU of 5ovr by Molmil
X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors
Descriptor: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{R})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid
Authors:Kack, H, Wissler, L.
Deposit date:2017-08-29
Release date:2017-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
J. Med. Chem., 60, 2017
5OVX
DownloadVisualize
BU of 5ovx by Molmil
X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors
Descriptor: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{S})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid
Authors:Kack, H, Wissler, L.
Deposit date:2017-08-30
Release date:2017-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
J. Med. Chem., 60, 2017
5OW1
DownloadVisualize
BU of 5ow1 by Molmil
X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors
Descriptor: Tyrosine-protein phosphatase non-receptor type 5, [[3-(3-cyclohexyl-2-oxidanyl-phenyl)phenyl]-bis(fluoranyl)methyl]phosphonic acid
Authors:Kack, H, Wissler, L.
Deposit date:2017-08-30
Release date:2017-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
J. Med. Chem., 60, 2017
3H2X
DownloadVisualize
BU of 3h2x by Molmil
Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain
Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 22
Authors:Tsai, S.J, Sen, U.
Deposit date:2009-04-14
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation .
Biochemistry, 48, 2009
7XC0
DownloadVisualize
BU of 7xc0 by Molmil
Crystal structure of Human RPTPH
Descriptor: PHOSPHATE ION, Receptor-type tyrosine-protein phosphatase H
Authors:Kim, M, Ryu, S.E.
Deposit date:2022-03-22
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of the catalytic domain of human RPTPH.
Acta Crystallogr.,Sect.F, 78, 2022
3I7Z
DownloadVisualize
BU of 3i7z by Molmil
Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ...
Authors:Brandao, T.A.S, Johnson, S.J, Hengge, A.C.
Deposit date:2009-07-09
Release date:2010-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
J.Biol.Chem., 285, 2010

225158

數據於2024-09-18公開中

PDB statisticsPDBj update infoContact PDBjnumon