7L0E
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3KVC
| Crystal structure of bovine RPE65 at 1.9 angstrom resolution | Descriptor: | FE (II) ION, Retinoid isomerohydrolase | Authors: | Kiser, P.D, Lodowski, D.T, Golczak, M, Palczewski, K. | Deposit date: | 2009-11-29 | Release date: | 2010-02-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J.Biol.Chem., 285, 2010
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4ZHK
| Crystal structure of RPE65 in complex with MB-002 | Descriptor: | (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ... | Authors: | Kiser, P.D, Palczewski, K. | Deposit date: | 2015-04-25 | Release date: | 2015-05-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125, 2015
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8SRL
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7QR6
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6B86
| 2.2A Crystal Structure of Co-CAO1 | Descriptor: | COBALT (II) ION, Carotenoid oxygenase 1 | Authors: | Hill, H.E, Kiser, P.D. | Deposit date: | 2017-10-05 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Preparation and characterization of metal-substituted carotenoid cleavage oxygenases. J. Biol. Inorg. Chem., 23, 2018
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3FSN
| Crystal structure of RPE65 at 2.14 angstrom resolution | Descriptor: | FE (II) ION, Retinal pigment epithelium-specific 65 kDa protein, TETRAETHYLENE GLYCOL | Authors: | Kiser, P.D, Lodowski, D.T, Palczewski, K. | Deposit date: | 2009-01-11 | Release date: | 2009-09-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc.Natl.Acad.Sci.USA, 106, 2009
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3NPE
| Structure of VP14 in complex with oxygen | Descriptor: | 1,4-DIETHYLENE DIOXIDE, 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic, ... | Authors: | Messing, S.A, Gabelli, S.B, Amzel, L.M. | Deposit date: | 2010-06-28 | Release date: | 2010-11-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. Plant Cell, 22, 2010
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8DOC
| Crystal structure of RPE65 in complex with compound 16e and palmitate | Descriptor: | (1R)-1-[3-(cyclohexylmethoxy)phenyl]-3-(methylamino)propan-1-ol, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, FE (II) ION, ... | Authors: | Bassetto, M, Kiser, P.D. | Deposit date: | 2022-07-12 | Release date: | 2023-05-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif. J.Med.Chem., 66, 2023
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7T8Q
| CRYSTAL STRUCTURE OF T151G CAO1 | Descriptor: | CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION | Authors: | Daruwalla, A, Kiser, P.D. | Deposit date: | 2021-12-16 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | CRYSTAL STRUCTURE OF T151G CAO1 To Be Published
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7T8P
| CRYSTAL STRUCTURE OF T151V CAO1 | Descriptor: | CHLORIDE ION, Carotenoid oxygenase 1, FE (II) ION | Authors: | Daruwalla, A, Kiser, P.D. | Deposit date: | 2021-12-16 | Release date: | 2023-07-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | CRYSTAL STRUCTURE OF T151V CAO1 To Be Published
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2BIX
| Crystal structure of apocarotenoid cleavage oxygenase from Synechocystis, Fe-free apoenzyme | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, APOCAROTENOID-CLEAVING OXYGENASE, GLYCEROL | Authors: | Kloer, D.P, Ruch, S, Al-Babili, S, Beyer, P, Schulz, G.E. | Deposit date: | 2005-01-26 | Release date: | 2005-04-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | The Structure of a Retinal-Forming Carotenoid Oxygenase Science, 308, 2005
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8FTY
| Crystal structure of the carotenoid isomerooxygenase, NinaB | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, CHLORIDE ION, ... | Authors: | Kiser, P.D, Solano, Y.J. | Deposit date: | 2023-01-14 | Release date: | 2024-01-17 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nat.Chem.Biol., 20, 2024
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2BIW
| Crystal structure of apocarotenoid cleavage oxygenase from Synechocystis, native enzyme | Descriptor: | (3R)-3-HYDROXY-8'-APOCAROTENOL, APOCAROTENOID-CLEAVING OXYGENASE, FE (III) ION | Authors: | Kloer, D.P, Ruch, S, Al-Babili, S, Beyer, P, Schulz, G.E. | Deposit date: | 2005-01-26 | Release date: | 2005-04-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | The Structure of a Retinal-Forming Carotenoid Oxygenase Science, 308, 2005
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4OU9
| Crystal structure of apocarotenoid oxygenase in the presence of Triton X-100 | Descriptor: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION | Authors: | Sui, X, Palczewski, K, Kiser, P.D. | Deposit date: | 2014-02-15 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO). J.Biol.Chem., 289, 2014
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5J54
| The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase | Descriptor: | Carotenoid oxygenase, FE (III) ION, OXYGEN MOLECULE, ... | Authors: | McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D. | Deposit date: | 2016-04-01 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5J55
| The Structure and Mechanism of NOV1, a Resveratrol-Cleaving Dioxygenase | Descriptor: | 4-hydroxy-3-methoxybenzaldehyde, Carotenoid oxygenase, FE (III) ION, ... | Authors: | McAndrew, R.P, Pereira, J.H, Sathitsuksanoh, N, Sale, K.L, Simmons, B.A, Adams, P.D. | Deposit date: | 2016-04-01 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure and mechanism of NOV1, a resveratrol-cleaving dioxygenase. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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4OU8
| Crystal structure of apocarotenoid oxygenase in the presence of C8E6 | Descriptor: | Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION | Authors: | Sui, X, Shi, W, Palczewski, K, Kiser, P.D. | Deposit date: | 2014-02-15 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Analysis of Carotenoid Isomerase Activity in a Prototypical Carotenoid Cleavage Enzyme, Apocarotenoid Oxygenase (ACO). J.Biol.Chem., 289, 2014
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7WH1
| structure of C elegans BCMO-2 | Descriptor: | Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ... | Authors: | Pan, W, Liu, L. | Deposit date: | 2021-12-29 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans . Front Mol Biosci, 9, 2022
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7WH0
| structure of C elegans BCMO-1 | Descriptor: | Beta-Carotene 15,15'-MonoOxygenase, FE (III) ION, GLYCEROL, ... | Authors: | Pan, W, Liu, L. | Deposit date: | 2021-12-29 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans . Front Mol Biosci, 9, 2022
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6OJW
| Crystal structure of Sphingomonas paucimobilis TMY1009 holo-LsdA | Descriptor: | FE (III) ION, GLYCEROL, Lignostilbene-alpha,beta-dioxygenase isozyme I, ... | Authors: | Kuatsjah, E, Verstraete, M.M, Kobylarz, M.J, Liu, A.K.N, Murphy, M.E.P, Eltis, L.D. | Deposit date: | 2019-04-12 | Release date: | 2019-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. J.Biol.Chem., 294, 2019
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6OJR
| Crystal structure of Sphingomonas paucimobilis TMY1009 apo-LsdA | Descriptor: | GLYCEROL, Lignostilbene-alpha,beta-dioxygenase isozyme I, MAGNESIUM ION | Authors: | Kuatsjah, E, Verstraete, M.M, Kobylarz, M.J, Liu, A.K.N, Murphy, M.E.P, Eltis, L.D. | Deposit date: | 2019-04-12 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. J.Biol.Chem., 294, 2019
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7VUD
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6OJT
| Crystal structure of Sphingomonas paucimobilis TMY1009 LsdA phenylazophenol complex | Descriptor: | 4-Hydroxyazobenzene, FE (III) ION, Lignostilbene-alpha,beta-dioxygenase isozyme I | Authors: | Kuatsjah, E, Verstraete, M.M, Kobylarz, M.J, Liu, A.K.N, Murphy, M.E.P, Eltis, L.D. | Deposit date: | 2019-04-12 | Release date: | 2019-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase. J.Biol.Chem., 294, 2019
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6VCG
| Crystal structure of Nitrosotalea devanaterra carotenoid cleavage dioxygenase, cobalt form | Descriptor: | CHLORIDE ION, COBALT (II) ION, SODIUM ION, ... | Authors: | Daruwalla, A, Shi, W, Kiser, P.D. | Deposit date: | 2019-12-20 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase. Proc.Natl.Acad.Sci.USA, 117, 2020
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