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- EMDB-40619: cryo-EM structure of sea urchin sperm doublet microtubule (48-nm ... -

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Basic information

Entry
Database: EMDB / ID: EMD-40619
Titlecryo-EM structure of sea urchin sperm doublet microtubule (48-nm periodicity)
Map data
Sample
  • Organelle or cellular component: sea urchin sperm doublet microtubule
    • Protein or peptide: x 55 types
  • Ligand: x 3 types
Keywordssperm / doublet microtubule / DMT / microtubule inner protein / cilia / flagella / FAP / CFAP / MIP / MAP / cytoskeleton / tublin / sea urchin / TEX / Tektin / SAXO / ODF / SPATA / RIB / STRUCTURAL PROTEIN
Function / homology
Function and homology information


cilium-dependent cell motility / regulation of cilium beat frequency involved in ciliary motility / : / cilium movement involved in cell motility / axoneme assembly / axonemal microtubule / cilium organization / nucleoside-diphosphate kinase / UTP biosynthetic process / CTP biosynthetic process ...cilium-dependent cell motility / regulation of cilium beat frequency involved in ciliary motility / : / cilium movement involved in cell motility / axoneme assembly / axonemal microtubule / cilium organization / nucleoside-diphosphate kinase / UTP biosynthetic process / CTP biosynthetic process / motile cilium / positive regulation of cell motility / GTP biosynthetic process / nucleoside diphosphate kinase activity / ciliary base / regulation of neuron projection development / axoneme / alpha-tubulin binding / mitotic cytokinesis / cilium assembly / sperm flagellum / phosphatase binding / microtubule-based process / Hsp70 protein binding / mitotic spindle organization / acrosomal vesicle / ciliary basal body / Hsp90 protein binding / structural constituent of cytoskeleton / mitotic spindle / microtubule cytoskeleton organization / microtubule cytoskeleton / mitotic cell cycle / protein-folding chaperone binding / microtubule binding / spermatogenesis / vesicle / microtubule / cytoskeleton / calmodulin binding / hydrolase activity / neuron projection / phosphorylation / GTPase activity / centrosome / calcium ion binding / GTP binding / positive regulation of transcription by RNA polymerase II / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm
Similarity search - Function
Coiled-coil domain-containing protein 81 / Testicular haploid expressed repeat / Uncharacterised protein family C20orf85 / Protein of unknown function DUF4562 / Testis-expressed protein 33 / Protein of unknown function DUF4586 / Hemingway/CFA97 / CFAP97 domain-containing protein 1/2 / Testicular haploid expressed gene protein-like / Hemingway/CFA97 ...Coiled-coil domain-containing protein 81 / Testicular haploid expressed repeat / Uncharacterised protein family C20orf85 / Protein of unknown function DUF4562 / Testis-expressed protein 33 / Protein of unknown function DUF4586 / Hemingway/CFA97 / CFAP97 domain-containing protein 1/2 / Testicular haploid expressed gene protein-like / Hemingway/CFA97 / Testicular haploid expressed repeat / Normal lung function maintenance, Low in Lung Cancer 1 protein / Domain of unknown function (DUF4562) / Domain of unknown function (DUF4586) / Testis-expressed sequence 33 protein family / Repeats in THEG (testicular haploid expressed gene) and several fly proteins. / CCDC81, HU domain 1 / Protein phosphatase 1 regulatory subunit 32 / Testis, prostate and placenta-expressed protein / Testis-expressed protein 49 / CCDC81, HU domain 2 / CCDC81 eukaryotic HU domain 1 / Protein phosphatase 1 regulatory subunit 32 / CCDC81 eukaryotic HU domain 2 / Protein of unknown function DUF1143 / Sperm-tail PG-rich repeat / Protein of unknown function DUF4541 / Protein of unknown function DUF4513 / Protein of unknown function (DUF1143) / Sperm-tail PG-rich repeat / Domain of unknown function (DUF4513) / Domain of unknown function (DUF4541) / FAM183 family / Coiled-coil domain-containing protein 105 / FAM183A and FAM183B related / Sperm-associated antigen 8 / Cilia- and flagella-associated protein 95 / NDPK7, first NDPk domain / Cilia- and flagella-associated protein 107 / Protein CFAP95 / Tektin / Cilia- and flagella-associated protein 276 / Tektin family / Protein of unknown function (DUF3695) / Cilia- and flagella-associated protein 77 / Cilia- and flagella-associated protein 77 / Uncharacterised protein FAM166/UPF0605 / Protein of unknown function (DUF2475) / Nucleoside diphosphate kinase 7 / Meiosis-specific nuclear structural protein 1 / Piercer of microtubule wall 1/2 / Cilia- and flagella-associated protein 141 / Cilia- and flagella-associated protein 45 / NDPK7, second NDPk domain / Protein Flattop / Cilia- and flagella- associated protein 210 / CFAP53/TCHP / Trichohyalin-plectin-homology domain / Trichohyalin-plectin-homology domain / Piercer of microtubule wall 1/2 / Cilia- and flagella-associated protein 141 / RIB43A / RIB43A / DM10 domain / EF-hand domain-containing protein EFHC1/EFHC2/EFHB / DM10 domain / DM10 domain profile. / Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases. / Enkurin domain / Calmodulin-binding / Enkurin domain profile. / CFA20 domain / Cilia- and flagella-associated protein 20/CFAP20DC / CFA20 domain / Parkin co-regulated protein / Parkin co-regulated protein / Nucleoside diphosphate kinase, active site / Nucleoside diphosphate kinase (NDPK) active site signature. / Nucleoside diphosphate kinase / Nucleoside diphosphate kinase-like domain / Nucleoside diphosphate kinase / NDK / Nucleoside diphosphate kinase-like domain superfamily / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamily
Similarity search - Domain/homology
Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Cilia- and flagella-associated protein 97 / Uncharacterized protein / Uncharacterized protein / Protein FAM166B / Uncharacterized protein / Flagellar FliJ protein / TEPP protein ...Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Cilia- and flagella-associated protein 97 / Uncharacterized protein / Uncharacterized protein / Protein FAM166B / Uncharacterized protein / Flagellar FliJ protein / TEPP protein / Sperm-associated antigen 8 / Cilia- and flagella-associated protein 126 / Cilia- and flagella-associated protein 45 / Meiosis-specific nuclear structural protein 1 / Uncharacterized protein / Tubulin beta chain / Cilia- and flagella-associated protein 52 / Protein phosphatase 1 regulatory subunit 32 / Coiled-coil domain-containing protein 81 / Cilia- and flagella-associated protein 161 / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Coiled-coil domain-containing protein 105 / Outer dense fiber protein 3 / RIB43A-like with coiled-coils protein 2 / Uncharacterized protein / Meiosis-specific nuclear structural protein 1 / Uncharacterized protein / Trichohyalin-plectin-homology domain-containing protein / Uncharacterized protein / EF-hand domain-containing protein / Uncharacterized protein / Testicular haploid expressed gene protein-like / Enkurin domain-containing protein / Tubulin alpha chain / Uncharacterized protein / Uncharacterized protein / Trichohyalin-plectin-homology domain-containing protein / EF-hand domain-containing family member C2 / Uncharacterized protein / Uncharacterized protein / Outer dense fiber protein 3 / CFA20 domain-containing protein / Nucleoside diphosphate kinase / Tektin / Uncharacterized protein / Cilia- and flagella-associated protein 77 / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Tektin / Flagellar protofilament ribbon protein rib74 / Tektin
Similarity search - Component
Biological speciesStrongylocentrotus purpuratus (purple sea urchin) / purple sea urchin (purple sea urchin)
Methodsingle particle reconstruction / cryo EM / Resolution: 3.3 Å
AuthorsZeng J / Zhang R
Funding support United States, 1 items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)1R01GM138854 United States
CitationJournal: Cell / Year: 2023
Title: Structural specializations of the sperm tail.
Authors: Miguel Ricardo Leung / Jianwei Zeng / Xiangli Wang / Marc C Roelofs / Wei Huang / Riccardo Zenezini Chiozzi / Johannes F Hevler / Albert J R Heck / Susan K Dutcher / Alan Brown / Rui Zhang / ...Authors: Miguel Ricardo Leung / Jianwei Zeng / Xiangli Wang / Marc C Roelofs / Wei Huang / Riccardo Zenezini Chiozzi / Johannes F Hevler / Albert J R Heck / Susan K Dutcher / Alan Brown / Rui Zhang / Tzviya Zeev-Ben-Mordehai /
Abstract: Sperm motility is crucial to reproductive success in sexually reproducing organisms. Impaired sperm movement causes male infertility, which is increasing globally. Sperm are powered by a microtubule- ...Sperm motility is crucial to reproductive success in sexually reproducing organisms. Impaired sperm movement causes male infertility, which is increasing globally. Sperm are powered by a microtubule-based molecular machine-the axoneme-but it is unclear how axonemal microtubules are ornamented to support motility in diverse fertilization environments. Here, we present high-resolution structures of native axonemal doublet microtubules (DMTs) from sea urchin and bovine sperm, representing external and internal fertilizers. We identify >60 proteins decorating sperm DMTs; at least 15 are sperm associated and 16 are linked to infertility. By comparing DMTs across species and cell types, we define core microtubule inner proteins (MIPs) and analyze evolution of the tektin bundle. We identify conserved axonemal microtubule-associated proteins (MAPs) with unique tubulin-binding modes. Additionally, we identify a testis-specific serine/threonine kinase that links DMTs to outer dense fibers in mammalian sperm. Our study provides structural foundations for understanding sperm evolution, motility, and dysfunction at a molecular level.
History
DepositionApr 26, 2023-
Header (metadata) releaseJun 28, 2023-
Map releaseJun 28, 2023-
UpdateJun 28, 2023-
Current statusJun 28, 2023Processing site: RCSB / Status: Released

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Structure visualization

Supplemental images

emd_40619.png

Downloads & links

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Map

FileDownload / File: emd_40619.map.gz / Format: CCP4 / Size: 512 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Voxel sizeX=Y=Z: 1.34 Å
Density
Contour LevelBy SOFTWARE: 6.63
Minimum - Maximum0.0 - 26.701248
Average (Standard dev.)0.24355884 (±1.1436546)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions512512512
Spacing512512512
CellA=B=C: 686.08 Å
α=β=γ: 90.0 °

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Supplemental data

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Additional map: #1

Fileemd_40619_additional_1.map
Projections & Slices
AxesZYX

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Histogram (log scale)

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Half map: #1

Fileemd_40619_half_map_1.map
Projections & Slices
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Histogram (log scale)

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Half map: #2

Fileemd_40619_half_map_2.map
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Sample components

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Entire : sea urchin sperm doublet microtubule

EntireName: sea urchin sperm doublet microtubule
Components
  • Organelle or cellular component: sea urchin sperm doublet microtubule
    • Protein or peptide: CFAP96(C4orf47)
    • Protein or peptide: Coiled-coil domain-containing protein 105
    • Protein or peptide: Coiled-coil domain-containing protein 81
    • Protein or peptide: FAM166C
    • Protein or peptide: Protein FAM166B
    • Protein or peptide: CFAP144(FAM183A)
    • Protein or peptide: Outer dense fiber protein 3
    • Protein or peptide: Tex33
    • Protein or peptide: C20Orf85
    • Protein or peptide: ATP6V1FNB
    • Protein or peptide: Tex26(LOC100888047)
    • Protein or peptide: Meiosis-specific nuclear structural protein 1
    • Protein or peptide: Enkurin domain-containing protein
    • Protein or peptide: CFAP107
    • Protein or peptide: Cilia- and flagella-associated protein 126
    • Protein or peptide: Flagellar FliJ protein
    • Protein or peptide: Meiosis-specific nuclear structural protein 1
    • Protein or peptide: Cilia- and flagella-associated protein 161
    • Protein or peptide: CFA20 domain-containing protein
    • Protein or peptide: CFAP21
    • Protein or peptide: Trichohyalin-plectin-homology domain-containing protein
    • Protein or peptide: CFAP276
    • Protein or peptide: Cilia- and flagella-associated protein 45
    • Protein or peptide: Cilia- and flagella-associated protein 52
    • Protein or peptide: Trichohyalin-plectin-homology domain-containing protein
    • Protein or peptide: Nucleoside diphosphate kinaseNucleoside-diphosphate kinase
    • Protein or peptide: Cilia- and flagella-associated protein 77
    • Protein or peptide: Cilia- and flagella-associated protein 97
    • Protein or peptide: HeLo_like_N(LOC577943)
    • Protein or peptide: Outer dense fiber protein 3
    • Protein or peptide: PACRG
    • Protein or peptide: Pierce1
    • Protein or peptide: Protein phosphatase 1 regulatory subunit 32
    • Protein or peptide: RIB35
    • Protein or peptide: RIB43A-like with coiled-coils protein 2
    • Protein or peptide: EF-hand domain-containing family member C2
    • Protein or peptide: Flagellar protofilament ribbon protein rib74
    • Protein or peptide: SAXO3(LOC115918676)
    • Protein or peptide: TEPP protein
    • Protein or peptide: SPATA48
    • Protein or peptide: Sperm-associated antigen 8
    • Protein or peptide: Testicular haploid expressed gene protein-like
    • Protein or peptide: Tektin A1
    • Protein or peptide: Tektin B1
    • Protein or peptide: Tektin C1
    • Protein or peptide: Tex43
    • Protein or peptide: Tex36(CFAP95, C9orf135)
    • Protein or peptide: CFAP90(C5orf49)
    • Protein or peptide: Tex49
    • Protein or peptide: Tex49_homologue(LOC580808)
    • Protein or peptide: CFAP68(UPF0686, C11orf1)
    • Protein or peptide: SPATA45
    • Protein or peptide: C4orf45
    • Protein or peptide: Tubulin alpha chain
    • Protein or peptide: Tubulin beta chain
  • Ligand: GUANOSINE-5'-TRIPHOSPHATEGuanosine triphosphate
  • Ligand: MAGNESIUM ION
  • Ligand: GUANOSINE-5'-DIPHOSPHATE

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Supramolecule #1: sea urchin sperm doublet microtubule

SupramoleculeName: sea urchin sperm doublet microtubule / type: organelle_or_cellular_component / ID: 1 / Parent: 0 / Macromolecule list: #1-#55
Source (natural)Organism: Strongylocentrotus purpuratus (purple sea urchin)

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Macromolecule #1: CFAP96(C4orf47)

MacromoleculeName: CFAP96(C4orf47) / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 33.406297 KDa
SequenceString: MSGKTDMERI GLFQEMGYVS IGDRYVPPGS KAFNEAAGKS KQMLPGGSKV RSALQAGYFD DKYTRVFESE GYSDAVKRRR QDRLKESKK NIGKAFLPSS GEKLMSGLGN HYGTLSGPVP ALSPVKKAGK AHKSDGKNVI TNPSKKGTGY GYPGLTLGKG I TYSPNAYD ...String:
MSGKTDMERI GLFQEMGYVS IGDRYVPPGS KAFNEAAGKS KQMLPGGSKV RSALQAGYFD DKYTRVFESE GYSDAVKRRR QDRLKESKK NIGKAFLPSS GEKLMSGLGN HYGTLSGPVP ALSPVKKAGK AHKSDGKNVI TNPSKKGTGY GYPGLTLGKG I TYSPNAYD KGKELRKKSL EQHKSSMKGG AFRLNMHPKA LFDANPYAHD RPLPPVKAKL ATKKISTPFK PSHPAKIIGG AK AGTFDPY PSHSNDPYRL KVKKGPPPTN SSGKIFTPSP GPKSAPTTSI INQNIIRTMN STNYRSIGTT LA

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Macromolecule #2: Coiled-coil domain-containing protein 105

MacromoleculeName: Coiled-coil domain-containing protein 105 / type: protein_or_peptide / ID: 2 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 49.945527 KDa
SequenceString: MMSTRSRTQI PLATATVGPQ SWSDATVKEI KISQAAVEKT DTGQEVGRSF DALPSLRDNC AQQSNTVVHQ YVRECRISLV KLRDSFLET NEEVKSLIRG KEALEKQLEH IRKDIALNKM STEIRCTRPS RERGRDGADN VMEKEFRHLH QLKKALELQL R SVQKQLQV ...String:
MMSTRSRTQI PLATATVGPQ SWSDATVKEI KISQAAVEKT DTGQEVGRSF DALPSLRDNC AQQSNTVVHQ YVRECRISLV KLRDSFLET NEEVKSLIRG KEALEKQLEH IRKDIALNKM STEIRCTRPS RERGRDGADN VMEKEFRHLH QLKKALELQL R SVQKQLQV LDQCRKRLSA VIQERNRVLD LLCHAVSSVN GRASRGGGRV SRQDKTMTFG GNGMGYTRQV NGNVAELLGT GA SPPDAEN RSGTPPPDPL GPFTPEAAAA IAQAREARQR SQFLRKDIRD AIENTQQLQQ AAHRAVNDGL NQKVAETITL KQH LTVAAG ENRHSIHRAQ RWYDSTEKAL GYTIGPELQS DLETREKLTR PIVRVFQRHP GTNLPEAQGI IRGAAGLDES LLRT SRNIG LLQLAQGRLQ GDIRHKHAGA SVDSAIVRGR RRLANHRWVM GSV

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Macromolecule #3: Coiled-coil domain-containing protein 81

MacromoleculeName: Coiled-coil domain-containing protein 81 / type: protein_or_peptide / ID: 3 / Number of copies: 9 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 79.691844 KDa
SequenceString: MTEVLSELVS DAKRHKFSTI PKLSDDDIVS VWENVANFVE RHMALQKGVQ IHGLGTFTFT QKKIDIGNNK FILIQRPVFV LSEKFAQTH RLSYTKHFTS GQVPIVQLNF AVLSNESPFD RDSVEGCVRE VLQALSRAVQ SKRNVEFSFT GIGRLTIRDS K VKMKFYKD ...String:
MTEVLSELVS DAKRHKFSTI PKLSDDDIVS VWENVANFVE RHMALQKGVQ IHGLGTFTFT QKKIDIGNNK FILIQRPVFV LSEKFAQTH RLSYTKHFTS GQVPIVQLNF AVLSNESPFD RDSVEGCVRE VLQALSRAVQ SKRNVEFSFT GIGRLTIRDS K VKMKFYKD FLTMMDGSGH LVEALKNRPD TADSVLSRAS VFRPSTSGTL VLPRITQGAG KDGFSFENGE AERQMPAIEE AR EYEEQEE ARLEYAPNQE DEGLGKEIEE EARKKPATPM RPSSRQVIPT AKATSIGFLD DLAPSPRPQS RGLKGTPSPP PGK PPSPKG ELPPPRLAAE IRESLANEAE AMERAESASC SHAHEKAGQE LCYLCHQRAV RNVPVSFESE RRRKEQEQDR LLQQ FQHLK DTESILRDQA QNMSNKHHSQ KIAAFNLGVS EAIKNKQKER STEFNRSYVF QNRARTPPRF LKQEEYATDL GSQVE AKAV DKIKRRQDTD FLERLEQVQL AEELSAQRER YLRDKHQQTD MYRKALSAQV RFKPLPLPGA VADSKEPIFG KFDATN EQL AERRRRAIEV FQDQISTVEN RRKNNLTNHV KTQNDETDML EKTRRELIAD RAARFEQAFQ TRKSLEETWK EADALKK SR EEEQVLKLQS SGILLHEQCD QYHRCEQCLR VLKNCGESNI WSESRYIPGS RLIM

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Macromolecule #4: FAM166C

MacromoleculeName: FAM166C / type: protein_or_peptide / ID: 4 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 23.728354 KDa
SequenceString: MSRSAGTLQT THQATYIPPR LMPGYKGHCP TMKFDYGETY GNATAKCLQD YRSTTLNNSK TNYSNGGQFP TVYTHNPDQV IGARDRTRE RFRTTPQYSL SNVNHDRKED INHFDKLAQE QREHYKDRTG TVGRVNEFLI PRSAQEMYHQ DSALIDEHVD M REEASTNM ...String:
MSRSAGTLQT THQATYIPPR LMPGYKGHCP TMKFDYGETY GNATAKCLQD YRSTTLNNSK TNYSNGGQFP TVYTHNPDQV IGARDRTRE RFRTTPQYSL SNVNHDRKED INHFDKLAQE QREHYKDRTG TVGRVNEFLI PRSAQEMYHQ DSALIDEHVD M REEASTNM ARNIPVERMS IPPIRTFSKS STVRDRAMRD VHYEHR

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Macromolecule #5: Protein FAM166B

MacromoleculeName: Protein FAM166B / type: protein_or_peptide / ID: 5 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 48.701172 KDa
SequenceString: MTSTIGCSRR AMFTFSVSFI HSHTSSVLNN QEIKSYKSQY NSTALIHDRK DIVRTYLRTS ERLFWSFEEK NMAKTSDSKT VAVQTNPNI PTGKSVLTNA EHYHTPGYCG FCPQFKFQIG ETFGRTTTRL LKDPSVPKSQ RTVLANIKPI SPGYPDRNTP A GRELLFQS ...String:
MTSTIGCSRR AMFTFSVSFI HSHTSSVLNN QEIKSYKSQY NSTALIHDRK DIVRTYLRTS ERLFWSFEEK NMAKTSDSKT VAVQTNPNI PTGKSVLTNA EHYHTPGYCG FCPQFKFQIG ETFGRTTTRL LKDPSVPKSQ RTVLANIKPI SPGYPDRNTP A GRELLFQS RKTSFGDQKF TEQMVPGYTG YIPKSQHYYG NRYAEECREA IATFEQDQQA ERKKRNTMKT VQQVQSGKLK PS KLPEETS VCRTCPLRQL PEVKPVRFNY ASANEKQHYM SPYYMKDENP QKKFMSGYTG YVPNARDVTG VGYPILTNRA LVK FTNDPN HPMVTGPPEG KGCTADTTGN VPVGCPVRTC QTSGKMPPME EKIIDEMRRL CGRQLPVIYP IESGLVPHYT GHIP GEKFR YGTTFGHSTR NAKREPNKKS NRTT

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Macromolecule #6: CFAP144(FAM183A)

MacromoleculeName: CFAP144(FAM183A) / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 16.431441 KDa
SequenceString:
MAAAQAKKPE KDPVNIVHQN AILCETIKKE NECQRLYTNY SINPFKKMYT LTGKPNSLHD SADGEEDDNF LRIIKRSTQE PGKKFEFPQ TEAQEVGWYY KPLLPQDRGD KRIHYPRQNT EITKYMDEAW KQKEQQENLQ

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Macromolecule #7: Outer dense fiber protein 3

MacromoleculeName: Outer dense fiber protein 3 / type: protein_or_peptide / ID: 7 / Number of copies: 13 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 27.28083 KDa
SequenceString: MNSSNYTPTI PRAPIAAHFT GPGPNVMLPS CLGNGTAINK REMPQFSFGV RHKSYSTDYS PGPCHNFPAG VTRKGNDGTP KYSLYARSK ELTAFKTPGP GSYSPEKAGR SAHLHAPEHT FGSRTKGITF DKSPAPNNYS LPSILGGRSC VKPSKPVYSM R GRNKMGGF ...String:
MNSSNYTPTI PRAPIAAHFT GPGPNVMLPS CLGNGTAINK REMPQFSFGV RHKSYSTDYS PGPCHNFPAG VTRKGNDGTP KYSLYARSK ELTAFKTPGP GSYSPEKAGR SAHLHAPEHT FGSRTKGITF DKSPAPNNYS LPSILGGRSC VKPSKPVYSM R GRNKMGGF DEDLQKTPGP GSYDVVDPAI YKNKSPMYSI TGRNQLPCDS TRKPGPGQHS PEKVTVNKRM APKFSFGVPH SQ YTTPLII QSDY

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Macromolecule #8: Tex33

MacromoleculeName: Tex33 / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 40.544223 KDa
SequenceString: MAVSLGNIKA KRTQAVAPRS LFGTVIEVAN EDDIQHAKSL PVPKRRMKKD KLGNYMAPDA NGVLKNELAE VERQMHKARF AENDLKEAS HLALTFHPNP DTIKTGIPDG ALSFKPKNQY APYKQDIKLH SRDISLTEHF NKPMGIDANP DYNYERYRRP Y TNTQFQQA ...String:
MAVSLGNIKA KRTQAVAPRS LFGTVIEVAN EDDIQHAKSL PVPKRRMKKD KLGNYMAPDA NGVLKNELAE VERQMHKARF AENDLKEAS HLALTFHPNP DTIKTGIPDG ALSFKPKNQY APYKQDIKLH SRDISLTEHF NKPMGIDANP DYNYERYRRP Y TNTQFQQA GTVLGKGGAF PKKDDESKSM RETFPPTTRR VRKTPSPGIQ PGQRAFPTDR IPDNIRFLHG EELCKEVAKE NE FLRKATP PPKRIPGPLI TAKFPPVKTS ISLDTDPMYS ALGTSLKQDI FNGVPHSHVK SLYKSSFTQD IHNKSVEVFP PKF AIQRNQ DSKWNEDGVI RMKLYKAWDA MTLERLQAKG GGT

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Macromolecule #9: C20Orf85

MacromoleculeName: C20Orf85 / type: protein_or_peptide / ID: 9 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 23.738551 KDa
SequenceString: MQAVNLKKNP NYVHIAERWK DHVRHEHRAW RNWPERWGFI TNEYTRMYKR LRGEQVSPDP EDKYFYDDCE RDGERESSVG PDESISRRF HPSDQSVSPS HSGAKLKHAS AYSDLPNIIN GSSWKERQSP NSTSIETVVN VTDIDVAHKA KSEKLPTIKT A PPAGYART ...String:
MQAVNLKKNP NYVHIAERWK DHVRHEHRAW RNWPERWGFI TNEYTRMYKR LRGEQVSPDP EDKYFYDDCE RDGERESSVG PDESISRRF HPSDQSVSPS HSGAKLKHAS AYSDLPNIIN GSSWKERQSP NSTSIETVVN VTDIDVAHKA KSEKLPTIKT A PPAGYART TASLIGWKQA NKLETFGRNA KGYKGILKQF NWPMQGIM

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Macromolecule #10: ATP6V1FNB

MacromoleculeName: ATP6V1FNB / type: protein_or_peptide / ID: 10 / Number of copies: 5 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 21.973307 KDa
SequenceString:
MGELFDVQRQ NFWTESIHKE AYTRLAWHEK YSKEFARESR EGGQAAVARK KRPDMVPKVK LIPVQSLKTK KTKKAADKTD ASKAQENSK KELEKIAGKD PNALLVEMRP VTSDVREQLF KGFSKEGTGR YAYLQMRKLK KPEMKYEVPL TSSWEYGWRL N DVVKEFRA PTYGRSRIVK DSFFRTNGIF

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Macromolecule #11: Tex26(LOC100888047)

MacromoleculeName: Tex26(LOC100888047) / type: protein_or_peptide / ID: 11 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 19.625033 KDa
SequenceString:
MPNSGFQGQI NQSFYGTHKA HLVPLGDQYV SGNLPNPAFW RRFIRDPVSS IENPSGTRVL TTTEVLAPVW QSNNCAANLS KNDRATSNT LPRLHTSSTW TTNEGSDHAP LRPQVPSSAR GRFRDAHIPL VALNSLAPFA TTYKPTCGYF FSRSTNNKKK Q MGIPATDL VKYRYYVK

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Macromolecule #12: Meiosis-specific nuclear structural protein 1

MacromoleculeName: Meiosis-specific nuclear structural protein 1 / type: protein_or_peptide / ID: 12 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 17.323562 KDa
SequenceString:
MSQQQYHWEA LRKQRVIDRR LAAMKKMTDE ERQMEELSTE GMARDELQSR QMDHAKRREL AEQIQHRDRR GIRNSYKERE QTIQKLVSE RTWHDNLIAK MDQSEKDDLL KDLLRDHAQK SKTLRDRGVY RGDAKFFIDP QYN

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Macromolecule #13: Enkurin domain-containing protein

MacromoleculeName: Enkurin domain-containing protein / type: protein_or_peptide / ID: 13 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 30.122543 KDa
SequenceString: MATMYGQQES IYNLIPQEEV KQEKQARYTS KFRGNVKVEE KTKKTSSKTM GPAKVELKKP EEFHKKHSKE PQLPPKTKFS YPDEETKRP AVPKRDEKPL MGLKSNKNFV NTNAVENIMS VPKKPAANFV DTVNGATHPL TPSGLMPKYV KKKGYGEVPT Y LQQRNEEV ...String:
MATMYGQQES IYNLIPQEEV KQEKQARYTS KFRGNVKVEE KTKKTSSKTM GPAKVELKKP EEFHKKHSKE PQLPPKTKFS YPDEETKRP AVPKRDEKPL MGLKSNKNFV NTNAVENIMS VPKKPAANFV DTVNGATHPL TPSGLMPKYV KKKGYGEVPT Y LQQRNEEV QRAQEEYDEY IKEHYRRGAM KCLTEEERKA IMDGLKKNWE EIHHQYQGLS VVTDTAPKKA RKERMEAEMK QL ERDIELL EKHKVIYISN H

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Macromolecule #14: CFAP107

MacromoleculeName: CFAP107 / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 27.343648 KDa
SequenceString: MAHGDPQKWN LPGWRIEQRY AGNVLIGNWS EERQKFGRGG EKHTSTHRMD YLNNRNFAPD VMTRRAAKMR NEGLDQTLLF AHHNKNLKN NLISWYDEQF NKRERSGGDQ LPELRHWDGQ KLAWEPEKTD HPVKGAPTNF GLKDRLQEKW KTEEADKKLS D YSTTYGLD ...String:
MAHGDPQKWN LPGWRIEQRY AGNVLIGNWS EERQKFGRGG EKHTSTHRMD YLNNRNFAPD VMTRRAAKMR NEGLDQTLLF AHHNKNLKN NLISWYDEQF NKRERSGGDQ LPELRHWDGQ KLAWEPEKTD HPVKGAPTNF GLKDRLQEKW KTEEADKKLS D YSTTYGLD YKNKPRAALV TEHFAPQRAQ SSRMHPVNKI NKDTNLRSTS ILQTPQQIHM RTRNEAVSRS GPAPVSV

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Macromolecule #15: Cilia- and flagella-associated protein 126

MacromoleculeName: Cilia- and flagella-associated protein 126 / type: protein_or_peptide / ID: 15 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 15.883667 KDa
SequenceString:
MSSHFSANQY KQAFDSRRLQ NSQIPQTYKE RPSSYEGFTQ IIANDRGHLK QGVPRSKDSP WGGFVGTWEM PKKIPGNVTT YMSRGDPAI DNIQKTRAEH NEYMRQAVSP DKTLAMEPKP QVTKVAEEDR PGNPSPNDAI PA

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Macromolecule #16: Flagellar FliJ protein

MacromoleculeName: Flagellar FliJ protein / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 14.037033 KDa
SequenceString:
MSEATSYRFE NNIENKSLQR ALHRQKERIK YDELMAAREG IVKNELLINQ KAVWTEKLEE ASAHRRLKTE KSAVKGEIAI AGKTLIAVR RAALRQLIDQ EYGQFEEELR AQGKAFYFKR D

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Macromolecule #17: Meiosis-specific nuclear structural protein 1

MacromoleculeName: Meiosis-specific nuclear structural protein 1 / type: protein_or_peptide / ID: 17 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 61.705172 KDa
SequenceString: MTTTRRQNLT HATQERMMVQ ARHQEDTRED HLKRLANEKV LEANMASEER VENKRHIRRV QQEEMERNMS ESILKAQQDR IQREQQMEQ EERITNRLQQ LKLETQRQEK VRQQIRENSL ELRELEAKLR AGYMNRERAA QIAEKEASKY EKTARDAEIA R LMMDESAR ...String:
MTTTRRQNLT HATQERMMVQ ARHQEDTRED HLKRLANEKV LEANMASEER VENKRHIRRV QQEEMERNMS ESILKAQQDR IQREQQMEQ EERITNRLQQ LKLETQRQEK VRQQIRENSL ELRELEAKLR AGYMNRERAA QIAEKEASKY EKTARDAEIA R LMMDESAR AESQEQRKLV EQYQESVHYQ QELEKQLEEK EKRKQEDYEE FLKEKLMIDE IVRKIHEEDE REREIYYEKQ HA TKRYIDE DAVARQKWKD LERQKMEQEN MEILKFATLQ QHREEDRMEN KRQQEEAKAS VQKNLSDDIA RKRAMEEEME RVR EELYHE EQEETQRQKE MAEIERQIRQ RLELQKTYQE QLRLKRMRRQ AEMGEEEEFK RQMLAKFEED DRIEQMNAQR RRMK QQEHK RRVEDLLADR RAQFAADKER ERDEREEAEN LERLRMQIIE EERQRLLKEH ASKLLGFLPK GVIRNEQDLE LFDDD FKRN YSGRQRNIHS AEGWE

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Macromolecule #18: Cilia- and flagella-associated protein 161

MacromoleculeName: Cilia- and flagella-associated protein 161 / type: protein_or_peptide / ID: 18 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 32.48074 KDa
SequenceString: MSVRSYNPSV RVGNWNEDTC LEEDMVKDFL EKKEKGELLI QKASNLRSTI LKPSDLSVTV DGFVHFGDTV VIMNEAAADQ VRTQPGVEP RQANVLSVNM SETKMHETMR FEGTCTASAS KSLNPCVRNT FVIAPAQDGI PPGSPLTYGQ HFRLCTLPGV G GNLVLQSD ...String:
MSVRSYNPSV RVGNWNEDTC LEEDMVKDFL EKKEKGELLI QKASNLRSTI LKPSDLSVTV DGFVHFGDTV VIMNEAAADQ VRTQPGVEP RQANVLSVNM SETKMHETMR FEGTCTASAS KSLNPCVRNT FVIAPAQDGI PPGSPLTYGQ HFRLCTLPGV G GNLVLQSD RVSFHASAEK SRKQLISFVD EVQSPYLTEW RILCFNPQIR MESEGLPVPA NQRIIFNHCK SNEDLCVVSG MS VRTPFGR EYEVVAHTDL DSHRAEKDVN HWIIKTGEPA QPTTLAKTLP VGDQQ

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Macromolecule #19: CFA20 domain-containing protein

MacromoleculeName: CFA20 domain-containing protein / type: protein_or_peptide / ID: 19 / Number of copies: 7 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 22.892596 KDa
SequenceString: MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIV GTNVSTTLIE CPADARKTLG IKLPFLVMII KNLKKYFTF EVQVLDDKNV RRRFRASNYQ STTRVKPFIC TMPMRLDDGW NQIQFNLSDF TRRAYGTNYI ETIRVNIHAN C RIRRVYFS ...String:
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIV GTNVSTTLIE CPADARKTLG IKLPFLVMII KNLKKYFTF EVQVLDDKNV RRRFRASNYQ STTRVKPFIC TMPMRLDDGW NQIQFNLSDF TRRAYGTNYI ETIRVNIHAN C RIRRVYFS DRLYSEDELP AEFKLYLPIQ KGMATKN

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Macromolecule #20: CFAP21

MacromoleculeName: CFAP21 / type: protein_or_peptide / ID: 20 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 66.165797 KDa
SequenceString: MAAIASPPTN GILRQTPPNS QGSEAIIASN TGKFKDRNSD MTAAGKLISM EGETTRDCMN IPRVQTPPLV KKFRNTTRPE PQVRRVFYG KAEDPDIAST VSHGVITTGS LKAGEVVNPN PKTLFTQRLS DKKESQYASK QKAPLGSSHD QRPGLPKDLN T LEKTFGTP ...String:
MAAIASPPTN GILRQTPPNS QGSEAIIASN TGKFKDRNSD MTAAGKLISM EGETTRDCMN IPRVQTPPLV KKFRNTTRPE PQVRRVFYG KAEDPDIAST VSHGVITTGS LKAGEVVNPN PKTLFTQRLS DKKESQYASK QKAPLGSSHD QRPGLPKDLN T LEKTFGTP NIFDCSAGEL VSPAKTYQQV YVESEEGREL YRKTHHNFHV GEPVDREYDW SQYSKDGLFG IPTPHENNGK NV AQTLKWL RNDHLDKGTK VVSKRVDDFR ERTQPQLGMV HDPIKETMTV PADHSYGVLL KPDEYGAGDL IHGRYPGSYL RGK DRERGL VAAIRQQLKK ANYHNFNNLQ AAFNHYDKNG DGKIDINELR LCCDQFSLPI EPELLEQLIL YCDANTNGCI DYFE FANFL NWKDKMNEGE TLTNPASAAV KGESQESKEG TPERLKKQID QAIGGHRTSA QMINAVVGGV STKGYRTYGV PTVRS DIAA PRTKRISDTK NYGDESDAFG LINPSMYSNK GIYEKDFFQP REPEQIKGIF SDIGVEMDPE TFHKLWSVAT SRSDQG QVS VESFRNVLDE VQALQLADEA QNLGRPELV

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Macromolecule #21: Trichohyalin-plectin-homology domain-containing protein

MacromoleculeName: Trichohyalin-plectin-homology domain-containing protein
type: protein_or_peptide / ID: 21 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 65.783406 KDa
SequenceString: MAQEQVRHGR RRGQKKNSPI GNRSGGAPPA GPGMMLPDGS DLRQVTVLSK ADWSRIRAQL ERKQREEEAF RAKREAKEAL HQQSKDMVK NWSNTIAGQR LQKLEARKIR EEKEEAERVQ IDIEEAKYQA EKRKEAIDKA KTLQYYQTDR VKGFHGALLL T EVLKERDA ...String:
MAQEQVRHGR RRGQKKNSPI GNRSGGAPPA GPGMMLPDGS DLRQVTVLSK ADWSRIRAQL ERKQREEEAF RAKREAKEAL HQQSKDMVK NWSNTIAGQR LQKLEARKIR EEKEEAERVQ IDIEEAKYQA EKRKEAIDKA KTLQYYQTDR VKGFHGALLL T EVLKERDA QLDLKRAREA AMEGNDMELY LRAQRELEEG ILADQEKALK RMQDRKANSE FQTQQIQEHL QQAEIDNIQD VR EGRELKE QVDYYNAERA KIERIRLGEK QDLMHSHLKT VADRDLIRAA QEQKEEEEEE EIRIFAAAKK KMTKLRRKRE KEL WQEKQD NVTRMVNDLD SQMKAKADDE DDRIAKAVAD REAAREKEMQ EKESRLEDDL KQMALHRTQQ MKQKEKEERQ ERRR ELEAL HLKIEADRLF ATKQEEKMKQ IRQENENLKG FHSNQIQERH ELKLLGRAEQ LEMDKKNIDL LALEEQQFQE YAGKV IKHC KEGERNVYPL EKAAREGHGG GHGPVFDGKG GIRPSYLTND RVGVELPYYQ KGSTDEVKYA HIGKPSNTRK RLGFVW

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Macromolecule #22: CFAP276

MacromoleculeName: CFAP276 / type: protein_or_peptide / ID: 22 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 19.508793 KDa
SequenceString:
MSNIEMSNRD PYPFEKLEND TSFFGTNETQ KMPYGEPTHI AQTKDPWQRL NSTCTLASSR REVYHHDPKA PRDSLDFILK ANYDHHGEL LKNRSETLMQ PETLGANHGR ILKNRVPEKV AEPVSPTGKL TIVSIHTPKK ESIHSVKGAI ESHHTPATNQ G FSRKHDGG FYTT

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Macromolecule #23: Cilia- and flagella-associated protein 45

MacromoleculeName: Cilia- and flagella-associated protein 45 / type: protein_or_peptide / ID: 23 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 64.116262 KDa
SequenceString: MPHSVISDSS TSSASRRAKT RQYYTVSKTS QVDESLFGSN NKNGSNKNTQ PTENTEPRRA SGGRNKKKQK EEVQVITKDL IRKLVVAQE DPSGQSVVLP FDEYRRIMGA ARTMSHEEKV ADFKRRQADK QKQQDASNEI KLHMQALDRK RQKNEKLTDL E EEAKEQGE ...String:
MPHSVISDSS TSSASRRAKT RQYYTVSKTS QVDESLFGSN NKNGSNKNTQ PTENTEPRRA SGGRNKKKQK EEVQVITKDL IRKLVVAQE DPSGQSVVLP FDEYRRIMGA ARTMSHEEKV ADFKRRQADK QKQQDASNEI KLHMQALDRK RQKNEKLTDL E EEAKEQGE YLLAKAREQQ EEQEDEIKHL NELMLNAKCH AIRDAQILEK GIIKEETTDE EKRLDAMMEV ERQRALLLQE EI EEQRKVE RYEGKSMILT QISQREEERL LQQEKKDQEA QQMLKYLGKL QVEDLKDLDR KRQIQLEAQK EIARSNEESE ELK KKKQEQ EKLADLKVNE YTKQKAEREA AFEAEQERIR IEKEKEIARL RAMQERAKDY QAEKDALRAK RNQEQREREW RQKE KEEVI IKAETEFMLK EAREVQVQNK EHFLAVQAQR ERAEFERVLR AQQEAMNKDR AEEEETKYNR LTHADDVRKQ IREKE QIRV SDRNAFFEEG VKINDEARDR RAKLDAIKKK KLGELRDAGV PDKYCAEVER KTMAVKH

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Macromolecule #24: Cilia- and flagella-associated protein 52

MacromoleculeName: Cilia- and flagella-associated protein 52 / type: protein_or_peptide / ID: 24 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 70.455148 KDa
SequenceString: MGDQQRKAVN GGEENNSDDI DRLELMSTIG FNGSSQGSLS VHPDRNHIVY PLGNTVIVEN LNSKKQDFLQ GHTNTVTCVT ISRSGRFIA SGQQTHMGFK AMIIVWDYEK RSVHCKLDLH KVKVQDLAFS PNDLYLVSLG GQDDGAIVIW DVMKKEAVCG S EAAVKSAG ...String:
MGDQQRKAVN GGEENNSDDI DRLELMSTIG FNGSSQGSLS VHPDRNHIVY PLGNTVIVEN LNSKKQDFLQ GHTNTVTCVT ISRSGRFIA SGQQTHMGFK AMIIVWDYEK RSVHCKLDLH KVKVQDLAFS PNDLYLVSLG GQDDGAIVIW DVMKKEAVCG S EAAVKSAG TTYCVAAANQ SDFLFFSGGE RTLRVWDLDV ENRKIRPTDV SLGQLKRIVK SIVVAPEDDY FYCATTTGDI LR IIASTKM LSCYGPKKDL FGMGVTSLVL VKDGTFLLGT GDGTVAHAKF IDDKFKVIKK KKIDKAGHIT SLTLRGQGHQ FFV GTSNSH IYRFNFSEFT YEMIRTCHYE EVNDIAFPKG CSELFVTSSK NDIRVWETAS CKELMRINVP NMECHAVCIM PDGK SIVSA WNDNKIRSFL PQSGKLLYEI ADAHNKAVTA LAVTSNNKRI ISGGGEGQVR VWDIFPREQK LRQTLKEHKG VVAFV RVNH SDTECVSAST DGTCIIWDLH KFVRSQVVFA NTLFRCVCYS AEQSQIITCG TDRKIAYWQA GDSSQIREVE GSKGGA INA MDMSSDGSNF VTGGDDALIK VWDYVNGVVT SIGVGHCSEI KRLRICPHQK YIISVSKDGA IFRWKYPSNC SL

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Macromolecule #25: Trichohyalin-plectin-homology domain-containing protein

MacromoleculeName: Trichohyalin-plectin-homology domain-containing protein
type: protein_or_peptide / ID: 25 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 62.040836 KDa
SequenceString: MLATQKPRRT REFTGPTPHS VAIRAKMPSK LPPDHLILER RKRDDQREEA EAATKYNALC DLKNDWEKTT DRRIQSNTVK RRVRSLMQQ EEFSLEDRRQ RLREMLAEEN DQYLVEMEAS QETLLERQSK MRERAKFLKE KREKERLKIV AEKLDQKWRE E CEELRSTL ...String:
MLATQKPRRT REFTGPTPHS VAIRAKMPSK LPPDHLILER RKRDDQREEA EAATKYNALC DLKNDWEKTT DRRIQSNTVK RRVRSLMQQ EEFSLEDRRQ RLREMLAEEN DQYLVEMEAS QETLLERQSK MRERAKFLKE KREKERLKIV AEKLDQKWRE E CEELRSTL TRRHMDEVCM DRSHQLETKA RMQAHDQEVE RMYADLWEKD RLAKEAKEEK IAQEQHGRNM EMLSVLQKQM AA IEAKRQE EKQLRIDGGK LRKEEAALRK LEEQRAMAEK RALQQEMRDG LDQNIKLKAK RMAKEVQEEL ALDMKILEKL LEE SRNEAM EITQRKKELR QEDQRYRKYL QEQMRLEQQR EAEIDRMISA EVERQWQKRL SQWAKERNAR KRLMEEVLAI RRQQ VEERL AANANAQAEL AKEREAMQAA MEEHKRLDDE KQAAILAANK NYEQNLLGQM EYTNRQQEQA KDEEYREYLH GLETE AEYQ AKLKEALARP VIDKAHPVRR QHMSARKSPQ IA

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Macromolecule #26: Nucleoside diphosphate kinase

MacromoleculeName: Nucleoside diphosphate kinase / type: protein_or_peptide / ID: 26 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 42.906504 KDa
SequenceString: MASSAQDGRY SFICEWYDPN AGLTRRYQFL FYPKDNTIEM FDLKNRRMFL KRSACDSVHL ADLYVGSTVN VHSRQLNLVE YSDDFTRRA LTTVKEKTLG LIKPDAISKF GPIFDMTYEA GFLVTNAKMT RLSRNAAEEF YAEHVGKPFY NNLVSFMCSG P IIALELMA ...String:
MASSAQDGRY SFICEWYDPN AGLTRRYQFL FYPKDNTIEM FDLKNRRMFL KRSACDSVHL ADLYVGSTVN VHSRQLNLVE YSDDFTRRA LTTVKEKTLG LIKPDAISKF GPIFDMTYEA GFLVTNAKMT RLSRNAAEEF YAEHVGKPFY NNLVSFMCSG P IIALELMA NNGIGEWRRL LGPTDSSTAR SEAPNSIRAR FGTDNTRNAC HGSDSVDSSN RETNFFFGPS ARMRNTSTLD NC TCCIIKP TAVKEGKAGQ IMSAICNEGF EVVALEMFHM EKANSEEFFE VYKGVVAEYM DMVTELTSGP CYALEIRCSK SDD VTKAFR DFVGPADPEI ARQLRPRTLR ARFGNDKVHN AVHCTDLPTD ALLEVEYFFK ILSE

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Macromolecule #27: Cilia- and flagella-associated protein 77

MacromoleculeName: Cilia- and flagella-associated protein 77 / type: protein_or_peptide / ID: 27 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 27.690299 KDa
SequenceString: MSAPSTPPFD NPLLKKSQLG RPLQRGYSLP GDVNFTYGRP NVTKDNGASE ALSGWSPSGP LMPITGHTER KPERDFIALN KACIGAGLV TASDQFQYRA THDVRRRISD EEKSKSKVKR IPASMTFGIS TRPSTPVFDL LEHKYQDRWL QERRKTELTK R ERHQQKQN ...String:
MSAPSTPPFD NPLLKKSQLG RPLQRGYSLP GDVNFTYGRP NVTKDNGASE ALSGWSPSGP LMPITGHTER KPERDFIALN KACIGAGLV TASDQFQYRA THDVRRRISD EEKSKSKVKR IPASMTFGIS TRPSTPVFDL LEHKYQDRWL QERRKTELTK R ERHQQKQN MNRGIYETRA SLLRKFCPPV EDPPLWQMSR FSRQLPHLET FRSPNAHHEA FAHHATDCTA RTGTFGHGIY ES AKS

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Macromolecule #28: Cilia- and flagella-associated protein 97

MacromoleculeName: Cilia- and flagella-associated protein 97 / type: protein_or_peptide / ID: 28 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 27.701848 KDa
SequenceString: MHRAYQPITP ANNKLLKKRW DEKRFDNHLQ KVQSARPVID DKPPKTYVHL HLKLKKMQME EERLTIIERD NRILLEKMCH IMLTRGNVD NKNFYDGKSL NRMARQRELL RVTHENQAIM RRILAKQATY SHHQWEDEWA MNLMYLKNIA KYPQWYEHAY D QWNKRDNH ...String:
MHRAYQPITP ANNKLLKKRW DEKRFDNHLQ KVQSARPVID DKPPKTYVHL HLKLKKMQME EERLTIIERD NRILLEKMCH IMLTRGNVD NKNFYDGKSL NRMARQRELL RVTHENQAIM RRILAKQATY SHHQWEDEWA MNLMYLKNIA KYPQWYEHAY D QWNKRDNH DSRNGSHYEP KKSSMMASLE KFSKKAEGNK KPNSEKKRAP RRSTKQSRDR QAKRGSANGC GVS

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Macromolecule #29: HeLo_like_N(LOC577943)

MacromoleculeName: HeLo_like_N(LOC577943) / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 34.673039 KDa
SequenceString: MTDTVPVPAV RPPVDKPMRL VGVSHSNNSY SLVDHASAND QLHYIFLVVK QHIAGILADV QYYKIAELKN EIIALGTDVA ALVRDRSFE ESRDKYHSHF WRADDEAENK RLIVKLSEVA YALLDYKQNC CTQSRGPYAL DEAKLEILCK KHLYELQNFR R ELAQFVNT ...String:
MTDTVPVPAV RPPVDKPMRL VGVSHSNNSY SLVDHASAND QLHYIFLVVK QHIAGILADV QYYKIAELKN EIIALGTDVA ALVRDRSFE ESRDKYHSHF WRADDEAENK RLIVKLSEVA YALLDYKQNC CTQSRGPYAL DEAKLEILCK KHLYELQNFR R ELAQFVNT ARDRNAQVTR LSAPLQSQLE WYQYKSPLDD PSIRRPLPYE CTLTSRETIR PRTEPPEVDG HISGVKHVPS QW DVPNLSG KPGAANSGTH GNLTSQGRYG GRHMYERNIN ERRKPCEQEI QHVSSRYKHY HGLCE

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Macromolecule #30: Outer dense fiber protein 3

MacromoleculeName: Outer dense fiber protein 3 / type: protein_or_peptide / ID: 30 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 30.624738 KDa
SequenceString: MSQQEEKTKQ KKRDMNDSPY AQPMSAKSKK SAEKPIIAAR ERGPGPGRYG LPSTSGFVAH DFTKHMKPAY SFGHRLENSM FQKDCSPGP GYKIHSEITR VGKDGTPAYS MLARQKDPNT FITPSPYAYS PEKVHPQGER HAPVHSMGSR TRFRKRDQAP A PNSYDLPV ...String:
MSQQEEKTKQ KKRDMNDSPY AQPMSAKSKK SAEKPIIAAR ERGPGPGRYG LPSTSGFVAH DFTKHMKPAY SFGHRLENSM FQKDCSPGP GYKIHSEITR VGKDGTPAYS MLARQKDPNT FITPSPYAYS PEKVHPQGER HAPVHSMGSR TRFRKRDQAP A PNSYDLPV LLGSKVPNKY SSASHSMTGR PHVGSYLEDH AKCPGPGSHD AIHPDVTKFK KPSYSMLGRH DLANDSATKP GP GAHSPEK VTVNKRKYPS HSLGIRHSEF VCPLIVVVKD

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Macromolecule #31: PACRG

MacromoleculeName: PACRG / type: protein_or_peptide / ID: 31 / Number of copies: 6 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 26.652809 KDa
SequenceString: MMRSKASPKG NERKLKAEGF TTKSRMKNAV VVAPPAAGAF AEKPLLQGTS FRKFYNRGDF PIALEHDTKG NKIAWKVEIE KLDYHHYLP MFFDGLCETT HPYEFFARQG VHDMLEHGGS KILPVIPQLI IPIKSALNMK NRMVLCTTLK VLQHLVVSGE N VGEALVPY ...String:
MMRSKASPKG NERKLKAEGF TTKSRMKNAV VVAPPAAGAF AEKPLLQGTS FRKFYNRGDF PIALEHDTKG NKIAWKVEIE KLDYHHYLP MFFDGLCETT HPYEFFARQG VHDMLEHGGS KILPVIPQLI IPIKSALNMK NRMVLCTTLK VLQHLVVSGE N VGEALVPY YRQILPVLNT FKNNNLNSGD SIDYGQQRRE NIGDLIHEVL VAFEKKGGDD AFINIKYMVP THESSVLN

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Macromolecule #32: Pierce1

MacromoleculeName: Pierce1 / type: protein_or_peptide / ID: 32 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 13.920258 KDa
SequenceString:
MEQSGNQAQH HHAGAGQMET ERKERDQVLA TTTLEKNQGA KTSDHYRTQN LPHRFENPDV FEGYNHKPQN PLYYTTNMGY GSIPPTVDT VPTCFHAKTN KFSEHLGKCG MYRNEGLNTG MESS

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Macromolecule #33: Protein phosphatase 1 regulatory subunit 32

MacromoleculeName: Protein phosphatase 1 regulatory subunit 32 / type: protein_or_peptide / ID: 33 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 52.795879 KDa
SequenceString: MGRLPVGEPT AHMSATQGPD ANLMKFYSTS YATSFGVKHE PFVPRTTKHV GTGYQSNFRP GVYYSQRLDE VDNPAMGRIV SDNYNSITT KHYKPSIRSD GKDRFPENLN QVKSGFTEQN PINFPTVGQV RKVFVNTRDH GLGLKINGVL PKHRPLLYKL Q AKDPVSLE ...String:
MGRLPVGEPT AHMSATQGPD ANLMKFYSTS YATSFGVKHE PFVPRTTKHV GTGYQSNFRP GVYYSQRLDE VDNPAMGRIV SDNYNSITT KHYKPSIRSD GKDRFPENLN QVKSGFTEQN PINFPTVGQV RKVFVNTRDH GLGLKINGVL PKHRPLLYKL Q AKDPVSLE NAGHGPNFMS TEAKTRFSGR PSERKDCSTL TVGPKEGSGY THAYNVEPIS FHPGSPFKNT TPGTWTNRPT GN SIMKTDF LPSQQPSGDE RLPAIANRSD HETGFTHEKA KPLYVHRVMT DAYTKRDQVP GRVEDRIRKE DPAEYLNMTN PDN HSSIFK KSYEGQQRPS PSANEMQGRL FVGNKEMSGY SDNNDKPQAQ IPVEPYRWIS HYDTKFYDMN TKGRARAGRT FGAV MKQLP DGYTKSTSVH SYGPTLDTTH ELRSLHPYVA RSIKARDVFF DDHTHDAKKH VTINPIPQFL AASC

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Macromolecule #34: RIB35

MacromoleculeName: RIB35 / type: protein_or_peptide / ID: 34 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 34.957242 KDa
SequenceString: MSVTSANPAT PYTRAEFFNA CTSVLEGLNC LQRQQSVIDE RSWEVLNRLG QMVSDLRPEV KGNKEYWVDG PLVKFLTANV LKAKSVLQE MKRTCSQKSA ATNGPEYIER HLLQHVEDIR TSLEELETYH QQTLYRTDTT GIDAGVGQRM HTITQGPTEM T AGGLTQTP ...String:
MSVTSANPAT PYTRAEFFNA CTSVLEGLNC LQRQQSVIDE RSWEVLNRLG QMVSDLRPEV KGNKEYWVDG PLVKFLTANV LKAKSVLQE MKRTCSQKSA ATNGPEYIER HLLQHVEDIR TSLEELETYH QQTLYRTDTT GIDAGVGQRM HTITQGPTEM T AGGLTQTP PAEISLEPKG SGTFMKDLNN AKIATNDSYP GTSSQPMTGM WSSGLPHHPE TSKPGVFEHI QEMTNIYPEH DP NWPKREQ KPKLPFERTQ PPLVYPGIRD MHNYSNLPQF TGKDLPMPKI PNGEMGLRAP HVPHWDSTNH YSY

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Macromolecule #35: RIB43A-like with coiled-coils protein 2

MacromoleculeName: RIB43A-like with coiled-coils protein 2 / type: protein_or_peptide / ID: 35 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 45.16207 KDa
SequenceString: MYKLDLPIDL KENAAIERRR NLELERQSRI FNAKVRTIGV DVQVLKEQVH DRDLQEQREN DREEAFASDM IRNDKISELL QRRQEQDIR NLNSAMNEFR DLHQQPEGRR EWDLYDPEAK KKDKPARVSD DDPRCGPSSI QKFDGEDLGG KERKKLMEEQ M REWSTKQA ...String:
MYKLDLPIDL KENAAIERRR NLELERQSRI FNAKVRTIGV DVQVLKEQVH DRDLQEQREN DREEAFASDM IRNDKISELL QRRQEQDIR NLNSAMNEFR DLHQQPEGRR EWDLYDPEAK KKDKPARVSD DDPRCGPSSI QKFDGEDLGG KERKKLMEEQ M REWSTKQA KEKALQKKRQ EEADRLYDLH RREMDQRACE LAAAEEECRR AINLSTKDYN KSLADEQAEK DRLRREQELD DN FTELANH INGDMLTENP DVASSAFGPH RVITDRWKGM SPEQLEDIRR TQELQRQEKE RIKSDEAERD REWEAQRIAD ARA GILMDR EQERLRKELE RQQIASNSRL AEEQNAHQNF MDKEVYTNPP TAAYFQQFNK TSR

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Macromolecule #36: EF-hand domain-containing family member C2

MacromoleculeName: EF-hand domain-containing family member C2 / type: protein_or_peptide / ID: 36 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 85.763664 KDa
SequenceString: MSLPFLPGNS FNPRLGRDKF HKSQHFDYSN EVPMLVGGHK PGIGGDKLLG QTSQPQTSNI PLGQGNASPA WVAFDKQVLH FDAFFQEAV HEMRQQYRIR KCKIYFYLED DSIQVIEPLV ENSGIPQGTL IRRHRIPLPP PNDDQFYTVE HFNVDQEITL Y GRTFKITG ...String:
MSLPFLPGNS FNPRLGRDKF HKSQHFDYSN EVPMLVGGHK PGIGGDKLLG QTSQPQTSNI PLGQGNASPA WVAFDKQVLH FDAFFQEAV HEMRQQYRIR KCKIYFYLED DSIQVIEPLV ENSGIPQGTL IRRHRIPLPP PNDDQFYTVE HFNVDQEITL Y GRTFKITG CDQFTYNFLK KLGVRIKAPA ETPKDPYTGF RKGMDEAQQP LRPYEKVDTL KQFLDHDRHV LRFLCFWDDR DN MFGDLRE FYLHYFLADD TIEIKEIIQP NAGRDKTPMF LRRGRMSKIS PESLRQPGEI TGRTVLNVFG PTGHGGRYIL DSL KTGAVH SEFYMENDLT IGSTINANGR WLTLADCDDF TKEYYKQKYG VNDYSPVNYR NDPAGANKRH WPPYTGFGSE EDSL CSCMG LLPKPPRRDF IKFMEKDRHG LDSNVIRFVA RLDTTKPIDV DRRFIISYFL SDDTVAVFEP PERNSGIIGG KFLER GRIK KPNQARFGTE LSDYFTARDL YVGSRLNFHS FFFVLIDADE YAFRYMEKHA EEFPMSNIGF ISQKISTIAS QHKEKI KEF LNRNDPSNSG HLEFDLFRNL LVQLGGSQLS EHEIIVLARY YSDTQDVKLS VETLVSIVQE QLKKNSFENF TKLLEGF LQ HDTDKSGYLD GALVRSTCNA FHLPLPDDLL RALISRLEAN EDGLVNYNAL VTYLNWRDHP MTTAQYVAPP ANFDESWT G KDNGDRVKRV NYIALLQSIF PDM

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Macromolecule #37: Flagellar protofilament ribbon protein rib74

MacromoleculeName: Flagellar protofilament ribbon protein rib74 / type: protein_or_peptide / ID: 37 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 74.127648 KDa
SequenceString: MALPFLPGNS FTDPTQRKFH RSQSLGYKNG YALPARPEVG IGGEPLEVNQ LTLSELDELN NKRPTLTYGQ AKQAPPEDFI PAHVAFDKK VLKFNGFYKQ TVHESPSEYF RVRPVILYYY LEDDSISVIE PHVENSGMPQ GKLIKRMRLP KNDQGDHWHW K DINLNINV ...String:
MALPFLPGNS FTDPTQRKFH RSQSLGYKNG YALPARPEVG IGGEPLEVNQ LTLSELDELN NKRPTLTYGQ AKQAPPEDFI PAHVAFDKK VLKFNGFYKQ TVHESPSEYF RVRPVILYYY LEDDSISVIE PHVENSGMPQ GKLIKRMRLP KNDQGDHWHW K DINLNINV TFYGKVFHIT DCDRWTSDFM ASEGIELNAP VGAPTDPYTD SRKEKSAVDA FTTPSTFDKL KQFLDLDRKV LR FFCVWDD RSSMFGEQRP FIIQYYLVDD TVEVREVHDP NDGRDPFPLF LKRQRVPKDR DNVDSSFRAV VMELSNHEIK DWY NPPDFG IGKTVFIYNR PFLIYDADNF TKAYMQQNYG VQGSGPIKVS TEARNLAKMD LPPYNGFGSY EDSLQSCLSL VPQP PKKDF IKMLENDHKI LRFEAIMDSV RPEDKGRRFI ISYRLADDMI KIFEPPVRNS GIISGTFLER TRVTMPGSTP ENPKF YGPQ DLTVGSCLEV FNHRFVITDA DDYVLNYLEA HRQDFPGCEK TIHSIQATRA MGLPNKPLTL ASQKGAPMTV QRTPND LKR LLAEVKGQLR KDNYINFTSL TEAFLQYDRD RSGNIDVNEL KAACHKQNLP LDDDVMQALI AECGDENGRI SHAEFMK FL TWD

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Macromolecule #38: SAXO3(LOC115918676)

MacromoleculeName: SAXO3(LOC115918676) / type: protein_or_peptide / ID: 38 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 37.032676 KDa
SequenceString: MTGADRRFDL HQTSSGRGLD YRPEYYFPAS DFKTTINNPL PPQLAKQDEI IKPFQTTTGG AHDYKYHGGL MANPQHHKAP GHWNMHYNK DLREKLQQRG WRKPLTMGNQ ESEVQAQYKG DQMQMGVDFD NRLSGNPQPS DLQTHHQNCP APVRDSVPKY K PTLVRDDG ...String:
MTGADRRFDL HQTSSGRGLD YRPEYYFPAS DFKTTINNPL PPQLAKQDEI IKPFQTTTGG AHDYKYHGGL MANPQHHKAP GHWNMHYNK DLREKLQQRG WRKPLTMGNQ ESEVQAQYKG DQMQMGVDFD NRLSGNPQPS DLQTHHQNCP APVRDSVPKY K PTLVRDDG ALQLLDIYVP TSHHVHKRFT RHELDDYPKK DAATYWRCED YTQAWGHGTK HNPLPKGAEI HQRAPMVDEM VF KTAIKEP ARWPERFKRV PHAGMKTTMT SSYKTPSDPK MTELFSCPVD TPWVIPEAGP IQTFSVPNMY TTEYKTYASG KPI TV

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Macromolecule #39: TEPP protein

MacromoleculeName: TEPP protein / type: protein_or_peptide / ID: 39 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 21.414076 KDa
SequenceString:
MPTVEVPYYV PQYPTFRRAQ LAAVKEGLYH PSLPTFRRMD MDTAAHRLPD EHCRTTTGVG PADFQNATAT YFQPPANTYN GANITDTGR LLRETMKDDV KSLRLDWAKA KDIKELPQIK NTGQLRFSGY AVRYQKPAIS GSWRYTFTQE PRLDQYGQRP V PANIYSRY RDTFPQYSRN MSTDAFR

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Macromolecule #40: SPATA48

MacromoleculeName: SPATA48 / type: protein_or_peptide / ID: 40 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Strongylocentrotus purpuratus (purple sea urchin)
Molecular weightTheoretical: 23.009598 KDa
SequenceString: MTEQACLPVP KFRPPSSTLE RNADLVKYRP WRYDVGPATW QEITPPVWDR IQERARIKPR QSYPRPTPVI NTTAFTPIPA INRPKSGKS KLKDGGSISV NETITDLVKR ERLTSTYVRQ CPGYAGYRPR SPLRIPMENL NEPNLRMTTT MKASYRPLMF P LINMDHFP ...String:
MTEQACLPVP KFRPPSSTLE RNADLVKYRP WRYDVGPATW QEITPPVWDR IQERARIKPR QSYPRPTPVI NTTAFTPIPA INRPKSGKS KLKDGGSISV NETITDLVKR ERLTSTYVRQ CPGYAGYRPR SPLRIPMENL NEPNLRMTTT MKASYRPLMF P LINMDHFP HMGPMSRTVT LTYPCNPFNK VEKLRSYGGN DV

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Macromolecule #41: Sperm-associated antigen 8

MacromoleculeName: Sperm-associated antigen 8 / type: protein_or_peptide / ID: 41 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 23.161557 KDa
SequenceString: MATLNPARTL NNSGGRCLME NWVEERQVFQ TGLDSAGVNS TESYTSNSSL PYKDGHKGIL TRELDTAVEK ESNSMGSYQR PAQCGVRTV GRKKELMERA LYAKVSQELQ EEINEPSPVE EYKSVTQKDF YDDEFESELP APLYEHNVNT EQPITFWSHH K EKIPGVSQ ...String:
MATLNPARTL NNSGGRCLME NWVEERQVFQ TGLDSAGVNS TESYTSNSSL PYKDGHKGIL TRELDTAVEK ESNSMGSYQR PAQCGVRTV GRKKELMERA LYAKVSQELQ EEINEPSPVE EYKSVTQKDF YDDEFESELP APLYEHNVNT EQPITFWSHH K EKIPGVSQ IKTLDTPFKK NSAFSKPIAE GTDQPQPYEQ ETHPFL

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Macromolecule #42: Testicular haploid expressed gene protein-like

MacromoleculeName: Testicular haploid expressed gene protein-like / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 30.135172 KDa
SequenceString: MATEVEASQS GSQSSRRPPR LDVLSRPKQL PSTYREDRRS VYWVDKPPLM PGSDGTTKFA CTDWVGSLSN HKPIYSRYLS DRPSPKSVV SKAAQSAEAS DRVTVLAGPK DWARHFTLHR PVMTHVSKGA KQAGPSERIE SLAKPKTYQP LQIKDSWDFD I NVWDNEIS ...String:
MATEVEASQS GSQSSRRPPR LDVLSRPKQL PSTYREDRRS VYWVDKPPLM PGSDGTTKFA CTDWVGSLSN HKPIYSRYLS DRPSPKSVV SKAAQSAEAS DRVTVLAGPK DWARHFTLHR PVMTHVSKGA KQAGPSERIE SLAKPKTYQP LQIKDSWDFD I NVWDNEIS SAAKNARCSE RLETLAEPKA LHNHFRFANP IRWNTEDSTL KAIATLRLQQ LARPKSRGKN EYFDPYKVSS AA VHARATP RIDELCAPIP RKVRQKKAGA P

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Macromolecule #43: Tektin A1

MacromoleculeName: Tektin A1 / type: protein_or_peptide / ID: 43 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 53.036789 KDa
SequenceString: MDAGATLLSR SYAPTIPVYP TQTTVGTKTD QALSQDLAKM SGLGETGVYG VPTGAPAAQG FRSGKHTTQE WHESNYNKYF QSFTDRDNA ERLCHESKQL SNETHALTMR TQADVTKKLG DRMNDINFWK FELNREIEEM IEETDLLCAQ KKRLENALDA T EVPLKIAR ...String:
MDAGATLLSR SYAPTIPVYP TQTTVGTKTD QALSQDLAKM SGLGETGVYG VPTGAPAAQG FRSGKHTTQE WHESNYNKYF QSFTDRDNA ERLCHESKQL SNETHALTMR TQADVTKKLG DRMNDINFWK FELNREIEEM IEETDLLCAQ KKRLENALDA T EVPLKIAR DNLTCRSRRQ DIDLVGDRVE MALNKEVDII TKVQDLLKRT LEQSDRQIKL NRGSKHKLTM DWSDKLSAFK ID EKCTGLN NNSTEIQYKE GSAKFEAVQT NPQSWAEFSH DNVVRAEHER LASQQLRNLI DQILTDTSND MREQCNTVNT EFA RRIEEM NDAKTKMENH LLKTVEDIAG MEKNIKDLTQ AVKDKEAPMK VAQTRLDHRT HRPNVELCRD PAQYRMVQEV GEIQ DSIDK LQQKLAESKA SLKDLMDTRM ALEKEIALKK NSIFVDRDKC LKFRTRYPST SKLVGYQ

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Macromolecule #44: Tektin B1

MacromoleculeName: Tektin B1 / type: protein_or_peptide / ID: 44 / Number of copies: 5 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 49.845398 KDa
SequenceString: MSIKTDIASK PVTHFAPSDW HTNSHLLSTN AEKLRDNSHS TRQESSQLRN ETYNRTSWGI HDNTTRLSNR IDDIETWRET LEKTLADVD EEIRKLEEDK DLAERALEAK ALPLDVASEC KTLRDGRRDI DVVDDLANSE VGKEIDVIEG IKDALQAKVS S AFEQLCLL ...String:
MSIKTDIASK PVTHFAPSDW HTNSHLLSTN AEKLRDNSHS TRQESSQLRN ETYNRTSWGI HDNTTRLSNR IDDIETWRET LEKTLADVD EEIRKLEEDK DLAERALEAK ALPLDVASEC KTLRDGRRDI DVVDDLANSE VGKEIDVIEG IKDALQAKVS S AFEQLCLL QEARQQLHAD LRDKTEAKKI DTYCHDLTIS SPDICYQPNS TRTPKGSTTP QTWEDFSRYN KDRADAEMRS SQ RLREAIH STVAQTDNDL EAQRQATEFA LRKRIHEMKR AKDEDEWQKK NTEEEIAKQE RNIRELEQAI KDKENPLKLA MTR LENRTY RPNVELCRDN AQYGLVNEVH EIQDSIKALE KKLQDAHNAR DACEKQLYRI NKDLELKNNS LDLDNKCMQV REKL TTGPV TQTMNNLSTF KTDRELYTAQ RSLLA

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Macromolecule #45: Tektin C1

MacromoleculeName: Tektin C1 / type: protein_or_peptide / ID: 45 / Number of copies: 5 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 46.691652 KDa
SequenceString: MSKLIKAPQR FTHGEWNYSN HANYNSAEKQ RASAERLIDE SDRLIDETDE ATKKTQRDVN KKFEQRLDDV TYWKDELDRK LKDSKDEIE MLLAYKTRLE NALEACREPL AIVNQCLNDR EGRIGIDLVH DDVEKNLLKE REVIMGVMAL LQKTLDQVIE Q IRIMRSRR ...String:
MSKLIKAPQR FTHGEWNYSN HANYNSAEKQ RASAERLIDE SDRLIDETDE ATKKTQRDVN KKFEQRLDDV TYWKDELDRK LKDSKDEIE MLLAYKTRLE NALEACREPL AIVNQCLNDR EGRIGIDLVH DDVEKNLLKE REVIMGVMAL LQKTLDQVIE Q IRIMRSRR YNLEKDLTDK FGALDIDQDC RNLRDDNSTL QFKGGVAKIE TNSVTPEDWQ SFSNENILKA ERDRKNSADL RA VVDSLLK TTADDMQQQV DDTNLAFSKR IRETDMTKGK LETHLAKVEG QMREMEENIQ KLQKGVDDKM GPKKLSETRL DAR TNRPNV ELCRDPVQYR LIGEVTEINT SIARLQATLA QAQSELKGLI RNQLNLQEDI DIKSQSLNVD DTQCMTLRRS INIK RY

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Macromolecule #46: Tex43

MacromoleculeName: Tex43 / type: protein_or_peptide / ID: 46 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 14.191163 KDa
SequenceString:
MAEKKQNGTS YQSIPRFSKL HPVIPRRYVP EWKNDMKNRE LLVKNCEMSG IIPKGPHDES LFLDKRERMN EVEPRVRVEA KHPNFERYD GLRPEFHTAQ SKYQSSLMFR KDNTVGQDFQ

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Macromolecule #47: Tex36(CFAP95, C9orf135)

MacromoleculeName: Tex36(CFAP95, C9orf135) / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 25.701264 KDa
SequenceString: MNSYTTLPDY VERKGSLFLR SNHMDYSRPT LNSNWHQARE AEPKDYDING FETLQDRKLH NTTYRRIGDV TDGSFPLTTT QDHLEQANL KKDFEEKEPR KTMVNIDTIA HVDLDRDTGK PKTGFGSVLP RHNPEHDKRH LETTNRADYK PPYPYTAAPE Q LPDFADNS ...String:
MNSYTTLPDY VERKGSLFLR SNHMDYSRPT LNSNWHQARE AEPKDYDING FETLQDRKLH NTTYRRIGDV TDGSFPLTTT QDHLEQANL KKDFEEKEPR KTMVNIDTIA HVDLDRDTGK PKTGFGSVLP RHNPEHDKRH LETTNRADYK PPYPYTAAPE Q LPDFADNS NAYRKCHSQF TDTADYRHFG RNTYKDESGI YANTQLKRNI YQTTNTIPKV LE

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Macromolecule #48: CFAP90(C5orf49)

MacromoleculeName: CFAP90(C5orf49) / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 19.712092 KDa
SequenceString:
MAYPGEGQGM SNYGPSQQTS QQQKLLWVEI VGREQRIKKC HLAVKGGLSG IYKESENQQT SQKTGKMKEI TYFNNNKKSN STYDRLFHV KHGYQNKLHR DDREHTRGLK VYEEESSKAV PALSSSAYGH RPPLEKTTRK HARIEHVMKG FYRHRGTNLP E YGTETDLG THH

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Macromolecule #49: Tex49

MacromoleculeName: Tex49 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 17.482893 KDa
SequenceString:
MSFFNLTELG YQYPIRAQVK EPNSVYSYHL ANSLPAGSYV SHRPETAKLP PINMHKYNKV IEPVDNPEHH GSYVKFTERL HKHTRCAKG PNDIYRNPVT TAQLPGSWYR KEVPLKQSEP WTYVPRHVCV SSEMTKFVKE MSVTNREFSL F

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Macromolecule #50: Tex49_homologue(LOC580808)

MacromoleculeName: Tex49_homologue(LOC580808) / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 20.695467 KDa
SequenceString:
MTAQCMGNFG AHKWRYPEFM ADRYGRSNGS VDPESRHKQY DAGVSDQTVW VNKRYIPTDL RSTAPVPRRK LLASARLPHV ERDWVPLGE ASCRQISRAM EERQLYVSQP STRSEDWSTL RQILPSKGLP LRDSPPNWGT GNAYAPPMLG ARQRRFPHIN S PMTRYTDN MHTTHKLFKL H

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Macromolecule #51: CFAP68(UPF0686, C11orf1)

MacromoleculeName: CFAP68(UPF0686, C11orf1) / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 17.679635 KDa
SequenceString:
MASGDEVAFR SMVRGSGLGE VWTHTTDLEK FQQYGWRTTT KEDCYTPDTL IGNWNEERFD IKRIRVPKSL PSQYDHYFDT TQKSSYVSG PKPVPKHILH LAARESRSFP ASQPELDPPA VKERYNSFET TSRASYVDPK LRKNPVHQTE TSQR

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Macromolecule #52: SPATA45

MacromoleculeName: SPATA45 / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 9.870922 KDa
SequenceString:
MDPQKNYEMN NQRESWCAVE LSPLQDWCKS ERKHHGENFK SSVFNAKQGQ PESEARCTFE VNDKTHREKR HFPNKTSYSH LAI

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Macromolecule #53: C4orf45

MacromoleculeName: C4orf45 / type: protein_or_peptide / ID: 53 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 32.467586 KDa
SequenceString: MAAATDSRRT SAVAESMASR PYTDATWMTQ SGTHPMGKGQ ILFTGPSGIR DYKVNVVTDD RMVGIGTMSQ EGTSDLQYIW RGAPGAPPP RRRSQWVGEV GWFIPPYHDT KNTLSGNQIQ LKVFRKAQEE KYTHRFQEPW YLAPNDPDYK QNFPFTQGSK R NWRAPGQQ ...String:
MAAATDSRRT SAVAESMASR PYTDATWMTQ SGTHPMGKGQ ILFTGPSGIR DYKVNVVTDD RMVGIGTMSQ EGTSDLQYIW RGAPGAPPP RRRSQWVGEV GWFIPPYHDT KNTLSGNQIQ LKVFRKAQEE KYTHRFQEPW YLAPNDPDYK QNFPFTQGSK R NWRAPGQQ RSAEQLPPRP HTSFHSNDSR LPNVNNNAPP SSRPFTVQPP SSESISRPAS GQSAHSYSAH SYTPPGSRPG SG GGHESAY SSRSRGSQST LRSRGSSQTS HPSRRRITPA ATSVSSVYRA PTSDPDY

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Macromolecule #54: Tubulin alpha chain

MacromoleculeName: Tubulin alpha chain / type: protein_or_peptide / ID: 54 / Number of copies: 148 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 50.184496 KDa
SequenceString: MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVVDEVRT GTYRQLFHP EQLITGKEDA ANNYARGHYT IGKEIVDLVL DRIRKLADQC TGLQGFLIFH SFGGGTGSGF ASLLMERLSV D YGKKSKLE ...String:
MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVVDEVRT GTYRQLFHP EQLITGKEDA ANNYARGHYT IGKEIVDLVL DRIRKLADQC TGLQGFLIFH SFGGGTGSGF ASLLMERLSV D YGKKSKLE FAIYPAPQIS TAVVEPYNTI LTTHTTLEHS DCAFMVDNEA IYDICRRNLD IERPTYTNLN RLIAQIVSSI TA SLRFDGA LNVDLTEFQT NLVPYPRIHF PLATYAPVIS AEKAYHEQLS VAEITNACFE PANQMVKCDP RHGKYMACCM LYR GDVVPK DVNAAIATIK TKRTIQFVDW CPTGFKVGIN YQPPTVVPGG DLAKVQRAVC MLSNTTAIAE AWARLDHKFD LMYA KRAFV HWYVGEGMEE GEFSEAREDL AALEKDYEEV GVDSVEGEAE EEGEEY

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Macromolecule #55: Tubulin beta chain

MacromoleculeName: Tubulin beta chain / type: protein_or_peptide / ID: 55 / Number of copies: 150 / Enantiomer: LEVO
Source (natural)Organism: purple sea urchin (purple sea urchin)
Molecular weightTheoretical: 50.097988 KDa
SequenceString: MREIVHMQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDN FVFGQSGAGN NWAKGHYTEG AELVDSVLDV VRKEAESCDC LQGFQLTHSL GGGTGSGMGT LLISKIREEY P DRIMNTFS ...String:
MREIVHMQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDN FVFGQSGAGN NWAKGHYTEG AELVDSVLDV VRKEAESCDC LQGFQLTHSL GGGTGSGMGT LLISKIREEY P DRIMNTFS VVPSPKVSDT VVEPYNATLS VHQLVENTDE TYCIDNEALY DICFRTLKLT TPTYGDLNHL VSATMSGVTT CL RFPGQLN ADLRKLAVNM VPFPRLHFFM PGFAPLTSRG SQQYRALTVP ELTQQMFDAK NMMAACDPRH GRYLTVAAIF RGR MSMKEV DEQMLNVQNK NSSYFVEWIP NNVKTAVCDI PPRGLKMSAT FIGNSTAIQE LFKRISEQFT AMFRRKAFLH WYTG EGMDE MEFTEAESNM NDLVSEYQQY QDATAEEEGE FDEEEEGDEE AA

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Macromolecule #56: GUANOSINE-5'-TRIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 56 / Number of copies: 148 / Formula: GTP
Molecular weightTheoretical: 523.18 Da
Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM / Guanosine triphosphate

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Macromolecule #57: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 57 / Number of copies: 148 / Formula: MG
Molecular weightTheoretical: 24.305 Da

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Macromolecule #58: GUANOSINE-5'-DIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-DIPHOSPHATE / type: ligand / ID: 58 / Number of copies: 150 / Formula: GDP
Molecular weightTheoretical: 443.201 Da
Chemical component information

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM / Guanosine diphosphate

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation statefilament

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Sample preparation

BufferpH: 7.4
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeFEI TITAN KRIOS
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELDBright-field microscopy / Nominal defocus max: 2.5 µm / Nominal defocus min: 0.5 µm
Image recordingFilm or detector model: GATAN K3 BIOQUANTUM (6k x 4k) / Average electron dose: 34.0 e/Å2
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Startup modelType of model: EMDB MAP
EMDB ID:

20631

Initial angle assignmentType: MAXIMUM LIKELIHOOD
Final angle assignmentType: MAXIMUM LIKELIHOOD
Final reconstructionResolution.type: BY AUTHOR / Resolution: 3.3 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 127673

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