Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2VYR
DownloadVisualize
BU of 2vyr by Molmil
Structure of human MDM4 N-terminal domain bound to a single domain antibody
Descriptor: HUMAN SINGLE DOMAIN ANTIBODY, MDM4 PROTEIN, SULFATE ION
Authors:Yu, G.W, Vaysburd, M, Allen, M.D, Settanni, G, Fersht, A.R.
Deposit date:2008-07-28
Release date:2008-11-25
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody.
J.Mol.Biol., 385, 2009
6SI2
DownloadVisualize
BU of 6si2 by Molmil
p53 cancer mutant Y220S
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, GLYCEROL, ...
Authors:Joerger, A.C, Bauer, M.R, Structural Genomics Consortium (SGC)
Deposit date:2019-08-08
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020
8QWO
DownloadVisualize
BU of 8qwo by Molmil
Structure of p53 cancer mutant Y234C
Descriptor: Cellular tumor antigen p53, GLYCEROL, ZINC ION
Authors:Balourdas, D.I, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:2023-10-19
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis, 15, 2024
8QWK
DownloadVisualize
BU of 8qwk by Molmil
Structure of p53 cancer mutant Y126C
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION
Authors:Markl, A.M, Balourdas, D.I, Kraemer, A, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:2023-10-19
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis, 15, 2024
8QWP
DownloadVisualize
BU of 8qwp by Molmil
Structure of p53 cancer mutant Y236C
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, L(+)-TARTARIC ACID, ...
Authors:Balourdas, D.I, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:2023-10-19
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis, 15, 2024
8QWM
DownloadVisualize
BU of 8qwm by Molmil
Structure of p53 cancer mutant Y205C
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, L(+)-TARTARIC ACID, ...
Authors:Balourdas, D.I, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:2023-10-19
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis, 15, 2024
8QWL
DownloadVisualize
BU of 8qwl by Molmil
Structure of p53 cancer mutant Y163C
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, MALONATE ION, ...
Authors:Balourdas, D.I, Markl, A.M, Kraemer, A, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:2023-10-19
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis, 15, 2024
8QWN
DownloadVisualize
BU of 8qwn by Molmil
Structure of p53 cancer mutant Y220C (hexagonal crystal form)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Cellular tumor antigen p53, ...
Authors:Balourdas, D.I, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:2023-10-19
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis, 15, 2024
2X0W
DownloadVisualize
BU of 2x0w by Molmil
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-dimethoxy- 2-methylbenzothiazole
Descriptor: 5,6-DIMETHOXY-2-METHYL-1,3-BENZOTHIAZOLE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Kaar, J.L, Basse, N, Joerger, A.C, Fersht, A.R.
Deposit date:2009-12-17
Release date:2010-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant.
Chem.Biol., 17, 2010
2X0U
DownloadVisualize
BU of 2x0u by Molmil
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold
Descriptor: 6,7-DIHYDRO[1,4]DIOXINO[2,3-F][1,3]BENZOTHIAZOL-2-AMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C, Kaar, J.L, Basse, N, Fersht, A.R.
Deposit date:2009-12-17
Release date:2010-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant.
Chem.Biol., 17, 2010
2X0V
DownloadVisualize
BU of 2x0v by Molmil
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(trifluoromethyl)benzene-1,2-diamine
Descriptor: 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Basse, N, Kaar, J.L, Joerger, A.C, Fersht, A.R.
Deposit date:2009-12-17
Release date:2010-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant.
Chem.Biol., 17, 2010
6SHZ
DownloadVisualize
BU of 6shz by Molmil
p53 cancer mutant Y220C
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, GLYCEROL, ...
Authors:Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:2019-08-08
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020
6SI4
DownloadVisualize
BU of 6si4 by Molmil
p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323
Descriptor: 1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine, Cellular tumor antigen p53, GLYCEROL, ...
Authors:Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2019-08-08
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020
6SI0
DownloadVisualize
BU of 6si0 by Molmil
p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9323
Descriptor: 1,2-ETHANEDIOL, 1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2019-08-08
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020
6SI3
DownloadVisualize
BU of 6si3 by Molmil
p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9301
Descriptor: 1,2-ETHANEDIOL, 1-[7-bromanyl-9-[2,2,2-tris(fluoranyl)ethyl]carbazol-3-yl]-~{N}-methyl-methanamine, Cellular tumor antigen p53, ...
Authors:Joerger, A.C, Bauer, M.R, Structural Genomics Consortium (SGC)
Deposit date:2019-08-08
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020
6SI1
DownloadVisualize
BU of 6si1 by Molmil
p53 cancer mutant Y220H
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cellular tumor antigen p53, ...
Authors:Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2019-08-08
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
Acs Chem.Biol., 15, 2020

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon