4LGS
 
 | | Ricin A chain bound to camelid nanobody (VHH4) | | Descriptor: | Camelid nanobody (VHH4), Ricin | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-06-28 | | Release date: | 2014-06-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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4LGP
 | | Ricin A chain bound to camelid nanobody (VHH1) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ... | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-06-28 | | Release date: | 2014-06-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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4LHQ
 | | Ricin A chain bound to camelid nanobody (VHH8) | | Descriptor: | Camelid nanobody, Ricin | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-07-01 | | Release date: | 2014-06-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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8GCW
 | | Stx2A1(Y77A)-P6 peptide | | Descriptor: | P stalk protein, rRNA N-glycosylase | | Authors: | Rudolph, M.J, Li, X.P. | | Deposit date: | 2023-03-03 | | Release date: | 2024-03-06 | | Last modified: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2.
Acs Infect Dis., 10, 2024
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4Z9K
 | | Ricin A chain bound to camelid nanobody (VHH2)(F5) | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin, ... | | Authors: | Rudolph, M.J. | | Deposit date: | 2015-04-10 | | Release date: | 2016-07-20 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
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3MN3
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2NYE
 | | Crystal structure of the Bateman2 domain of yeast Snf4 | | Descriptor: | Nuclear protein SNF4 | | Authors: | Rudolph, M.J, Amodeo, G.A, Iram, S, Hong, S, Pirino, G, Carlson, M, Tong, L. | | Deposit date: | 2006-11-20 | | Release date: | 2006-12-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding.
Structure, 15, 2007
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2NYC
 | | Crystal structure of the Bateman2 domain of yeast Snf4 | | Descriptor: | Nuclear protein SNF4 | | Authors: | Rudolph, M.J, Amodeo, G.A, Iram, S, Hong, S, Pirino, G, Carlson, M, Tong, L. | | Deposit date: | 2006-11-20 | | Release date: | 2006-12-12 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding.
Structure, 15, 2007
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6CWK
 | | Anti-RTA VHH antibody | | Descriptor: | 1,2-ETHANEDIOL, Anti-Ricin antibody, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2018-03-30 | | Release date: | 2019-01-16 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (1.256 Å) | | Cite: | Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018
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6CWG
 | | Ricin catalytic subunit bound go A9 VHH antibody | | Descriptor: | CHLORIDE ION, Ricin, VHH antibody | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2018-03-30 | | Release date: | 2019-01-16 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.
Protein Eng. Des. Sel., 31, 2018
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5BOZ
 | | Ricin A chain bound to camelid nanobody (VHH9)(E1) | | Descriptor: | CHLORIDE ION, Ricin, SULFATE ION, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2015-05-27 | | Release date: | 2016-12-07 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit.
J. Biol. Chem., 292, 2017
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3HYH
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8CX8
 | | Stx2A1-BTB13086 | | Descriptor: | 1,2-ETHANEDIOL, 5-(4-chlorophenyl)furan-2-carboxylic acid, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Li, X.P. | | Deposit date: | 2022-05-20 | | Release date: | 2024-03-06 | | Last modified: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (1.905 Å) | | Cite: | Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2.
Acs Infect Dis., 10, 2024
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5E1H
 | | Ricin toxin in complex with neutralizing single chain monoclonal antibodies (VHHs) | | Descriptor: | CHLORIDE ION, F8(JOB10) VHH antibody, Ricin | | Authors: | Rudolph, M.J, Vance, D, Shoemaker, C, Mantis, N. | | Deposit date: | 2015-09-29 | | Release date: | 2016-08-03 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.032 Å) | | Cite: | Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.
Proteins, 84, 2016
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4LGR
 | | Ricin A chain bound to camelid nanobody (VHH3) | | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-06-28 | | Release date: | 2014-06-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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4LHJ
 | | Ricin A chain bound to camelid nanobody (VHH5) | | Descriptor: | CHLORIDE ION, Camelid antibody, Ricin | | Authors: | Rudolph, M.J, Cheung, J, Franklin, M, Burshteyn, F, Cassidy, M, Gary, E, Mantis, N. | | Deposit date: | 2013-07-01 | | Release date: | 2014-06-11 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies.
J.Mol.Biol., 426, 2014
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8TAD
 | | RTA in complex with inhibitor RUNT-206 | | Descriptor: | (9aM)-5,5-dimethyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, NONAETHYLENE GLYCOL, ... | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2023-06-27 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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8T9V
 | | RTA-RUNT-59 complex structure | | Descriptor: | (9aP)-7-fluoro-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, NONAETHYLENE GLYCOL, Ricin | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2023-06-26 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.945 Å) | | Cite: | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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8TAB
 | | RTA-PD00589 | | Descriptor: | 1,2-ETHANEDIOL, 4H,5H-naphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, ... | | Authors: | Rudolph, M.J, Tumer, N. | | Deposit date: | 2023-06-27 | | Release date: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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8SZ2
 | | Stx2A1 bound to P8 stalk peptide | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, NONAETHYLENE GLYCOL, ... | | Authors: | rudolph, M.J, Li, X.P. | | Deposit date: | 2023-05-26 | | Release date: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structure of Shiga toxin 2 A1 subunit with peptides that bind at the ribosome binding site and inhibit activity
To Be Published
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8TVD
 | | Fab 221-11 in complex with OspA | | Descriptor: | CHLORIDE ION, Heavy chain of Fab 221-11, Light chain of Fab 221-11, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-18 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (3.077 Å) | | Cite: | Fab 221-11 in complex with OspA
To Be Published
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8TV3
 | | Fab 221-5 in complex with OspA | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Heavy chain of human monoclonal Fab 221-5, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-17 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.312 Å) | | Cite: | Fab 221-5 in complex with OspA
To Be Published
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8TVJ
 | | Fab 227-1 in complex with OspA | | Descriptor: | Heavy chain of Fab 227-1, Light chain of Fab 227-1, Outer surface protein A | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-18 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (3.168 Å) | | Cite: | Fab 227-1 in complex with OspA
To Be Published
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8TUZ
 | | Fab 857-2 in complex with OspA | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Heavy chain of human monoclonal antibody 857-2, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-17 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.186 Å) | | Cite: | Fab 857-2 in complex with OspA
To Be Published
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6X6H
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