1QNL
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1QO0
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1UDI
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1PEA
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4APE
| THE ACTIVE SITE OF ASPARTIC PROTEINASES | Descriptor: | ENDOTHIAPEPSIN | Authors: | Pearl, L.H, Sewell, B.T, Jenkins, J.A, Cooper, J.B, Blundell, T.L. | Deposit date: | 1986-06-09 | Release date: | 1986-07-14 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Active Site of Aspartic Proteinases FEBS Lett., 174, 1984
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1UDH
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1UDG
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1GOW
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1AM1
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1AMW
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1GXR
| WD40 Region of Human Groucho/TLE1 | Descriptor: | CALCIUM ION, TRANSDUCIN-LIKE ENHANCER PROTEIN 1 | Authors: | Pearl, L.H, Roe, S.M, Pickles, L.M. | Deposit date: | 2002-04-10 | Release date: | 2002-06-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor Structure, 10, 2002
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1LAU
| URACIL-DNA GLYCOSYLASE | Descriptor: | DNA (5'-D(*TP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE (E.C.3.2.2.-)) | Authors: | Pearl, L.H, Savva, R. | Deposit date: | 1996-01-03 | Release date: | 1996-06-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structural basis of specific base-excision repair by uracil-DNA glycosylase. Nature, 373, 1995
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5LOH
| Kinase domain of human Greatwall | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, STAUROSPORINE, ... | Authors: | Rajasekaran, M.B, Pearl, L.H, Oliver, A.W. | Deposit date: | 2016-08-09 | Release date: | 2016-09-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7, 2016
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7OA5
| RUVA COMPLEXED TO A HOLLIDAY JUNCTION. | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*GP*TP*TP*CP*GP*CP*GP*AP*GP*TP*TP*CP*GP*C)-3'), DNA (5'-D(*AP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*AP*CP*T)-3'), ... | Authors: | Roe, S.M, Pearl, L.H. | Deposit date: | 2021-04-19 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.378 Å) | Cite: | Crystal structure of an octameric RuvA-Holliday junction complex Molecular Cell, 2, 1998
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7P0L
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7P0J
| Crystal structure of S.pombe Mdb1 BRCT domains | Descriptor: | CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ... | Authors: | Day, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2021-06-29 | Release date: | 2022-07-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair (Amst), 108, 2021
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6HM3
| Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide | Descriptor: | CALCIUM ION, DNA replication regulator sld3, GLYCEROL, ... | Authors: | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2018-09-12 | Release date: | 2018-10-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.77263618 Å) | Cite: | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. Elife, 7, 2018
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4V81
| The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, SULFATE ION, ... | Authors: | Dekker, C, Roe, S.M, McCormack, E.A, Beuron, F, Pearl, L.H, Willison, K.R. | Deposit date: | 2010-10-17 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. Embo J., 30, 2011
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7Z6H
| Structure of DNA-bound human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp | Descriptor: | Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1,Cell cycle checkpoint protein RAD17, Checkpoint protein HUS1, ... | Authors: | Day, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2022-03-11 | Release date: | 2022-05-04 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction. Nucleic Acids Res., 50, 2022
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8AG4
| Vaccinia C16 protein bound to Ku70/Ku80 | Descriptor: | Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | Authors: | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | Deposit date: | 2022-07-19 | Release date: | 2022-11-09 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
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8AG3
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8AG5
| Vaccinia C16 protein bound to Ku70/Ku80 | Descriptor: | Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5 | Authors: | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | Deposit date: | 2022-07-19 | Release date: | 2022-11-09 | Last modified: | 2022-11-30 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
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7ZR5
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7ZR0
| CryoEM structure of HSP90-CDC37-BRAF(V600E) complex. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... | Authors: | Oberoi, J, Pearl, L.H. | Deposit date: | 2022-05-03 | Release date: | 2022-12-14 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation. Nat Commun, 13, 2022
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7ZR6
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