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1CF7
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BU of 1cf7 by Molmil
STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP
Descriptor: DNA (5'-D(*AP*TP*TP*TP*TP*CP*GP*CP*GP*CP*GP*GP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*AP*AP*CP*CP*GP*CP*GP*CP*GP*AP*AP*AP*A)-3'), PROTEIN (TRANSCRIPTION FACTOR DP-2), ...
Authors:Zheng, N, Fraenkel, E, Pabo, C.O, Pavletich, N.P.
Deposit date:1999-03-24
Release date:1999-04-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP.
Genes Dev., 13, 1999
1FBV
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BU of 1fbv by Molmil
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Descriptor: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
Authors:Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P.
Deposit date:2000-07-17
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
1LDD
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BU of 1ldd by Molmil
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Descriptor: Anaphase Promoting Complex
Authors:Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1LDK
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BU of 1ldk by Molmil
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Descriptor: CULLIN HOMOLOG, CYCLIN A/CDK2-ASSOCIATED PROTEIN P19, SKP2-like protein type gamma, ...
Authors:Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1LDJ
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BU of 1ldj by Molmil
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Descriptor: Cullin homolog 1, ZINC ION, ring-box protein 1
Authors:Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
3RVZ
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BU of 3rvz by Molmil
Crystal structure of the NavAb voltage-gated sodium channel (Ile217Cys, 2.8 A)
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein
Authors:Payandeh, J, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2011-05-06
Release date:2011-07-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of a voltage-gated sodium channel.
Nature, 475, 2011
3RW0
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BU of 3rw0 by Molmil
Crystal structure of the NavAb voltage-gated sodium channel (Met221Cys, 2.95 A)
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein
Authors:Payandeh, J, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2011-05-06
Release date:2011-07-13
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:The crystal structure of a voltage-gated sodium channel.
Nature, 475, 2011
6P6W
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BU of 6p6w by Molmil
Cryo-EM structure of voltage-gated sodium channel NavAb N49K/L109A/M116V/G94C/Q150C disulfide crosslinked mutant in the resting state
Descriptor: Fusion of Maltose-binding protein and voltage-gated sodium channel NavAb
Authors:Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-Din, T.M, Wang, L, Zheng, N, Catterall, W.A.
Deposit date:2019-06-04
Release date:2019-08-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Cell, 178, 2019
6P6Y
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BU of 6p6y by Molmil
Crystal structure of voltage-gated sodium channel NavAb V100C/Q150C disulfide crosslinked mutant in the activated state
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-din, T.M, Wang, L, Zheng, N, Catterall, W.A.
Deposit date:2019-06-04
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Cell, 178, 2019
6P6X
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BU of 6p6x by Molmil
Crystal structure of voltage-gated sodium channel NavAb G94C/Q150C mutant in the activated state
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-Din, T.M, Wang, L, Zheng, N, Catterall, W.A.
Deposit date:2019-06-04
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Cell, 178, 2019
8DJ1
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BU of 8dj1 by Molmil
Crystal structure of NavAb V126T as a basis for the human Nav1.7 Inherited Erythromelalgia S241T mutation
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A.
Deposit date:2022-06-29
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DIZ
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BU of 8diz by Molmil
Crystal structure of NavAb I119T as a basis for the human Nav1.7 Inherited Erythromelalgia I234T mutation
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein
Authors:Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A.
Deposit date:2022-06-29
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DJ0
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BU of 8dj0 by Molmil
Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A.
Deposit date:2022-06-29
Release date:2023-04-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DIW
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BU of 8diw by Molmil
Crystal structure of NavAb E96P as a basis for the human Nav1.7 Inherited Erythromelalgia S211P mutation
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A.
Deposit date:2022-06-29
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.
J.Gen.Physiol., 155, 2023
8DIV
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BU of 8div by Molmil
Crystal structure of NavAb I22V as a basis for the human Nav1.7 Inherited Erythromelalgia I136V mutation
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein, ...
Authors:Wisedchaisri, G, Gamal El-Din, T.M, Powell, N.M, Zheng, N, Catterall, W.A.
Deposit date:2022-06-29
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.
J.Gen.Physiol., 155, 2023
8DIX
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BU of 8dix by Molmil
Structure of NavAb L98R as a basis for the human Nav1.7 Inherited Erythromelalgia L823R mutation
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein
Authors:Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A.
Deposit date:2022-06-29
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.
J.Gen.Physiol., 155, 2023
8DIY
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BU of 8diy by Molmil
Crystal structure of NavAb L101S as a basis for the human Nav1.7 Inherited Erythromelalgia F216S mutation
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A.
Deposit date:2022-06-29
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7.
J.Gen.Physiol., 155, 2023
6O60
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BU of 6o60 by Molmil
Crystal structure of GGTase3-FBXL2-SKP1 complex
Descriptor: F-box/LRR-repeat protein 2, Geranylgeranyl transferase type-2 subunit beta, Protein prenyltransferase alpha subunit repeat-containing protein 1, ...
Authors:Wang, H, Zheng, N.
Deposit date:2019-03-04
Release date:2019-06-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
Nat.Struct.Mol.Biol., 26, 2019
1MJE
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BU of 1mje by Molmil
STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX
Descriptor: 5'-D(P*TP*TP*TP*TP*TP*T)-3', Deleted in split hand/split foot protein 1, breast cancer 2
Authors:Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P.
Deposit date:2002-08-27
Release date:2002-09-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
1MIU
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BU of 1miu by Molmil
Structure of a BRCA2-DSS1 complex
Descriptor: Breast Cancer type 2 susceptibility protein, Deleted in split hand/split foot protein 1, MERCURY (II) ION
Authors:Yang, H, Jeffrey, P.D, Miller, J, Kinnucan, E, Sun, Y, Thoma, N.H, Zheng, N, Chen, P.L, Lee, W.H, Pavletich, N.P.
Deposit date:2002-08-23
Release date:2002-09-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
Science, 297, 2002
1U6G
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BU of 1u6g by Molmil
Crystal Structure of The Cand1-Cul1-Roc1 Complex
Descriptor: Cullin homolog 1, RING-box protein 1, TIP120 protein, ...
Authors:Goldenberg, S.J, Shumway, S.D, Cascio, T.C, Garbutt, K.C, Liu, J, Xiong, Y, Zheng, N.
Deposit date:2004-07-29
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
Cell(Cambridge,Mass.), 119, 2004
2P1N
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BU of 2p1n by Molmil
Mechanism of Auxin Perception by the TIR1 Ubiqutin Ligase
Descriptor: (2,4-DICHLOROPHENOXY)ACETIC ACID, Auxin-responsive protein IAA7, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Tan, X, Calderon-Villalobos, L.I.A, Sharon, M, Robinson, C.V, Estelle, M, Zheng, C, Zheng, N.
Deposit date:2007-03-06
Release date:2007-04-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of auxin perception by the TIR1 ubiquitin ligase
Nature, 446, 2007
7TE8
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BU of 7te8 by Molmil
CA14-CBD-DB21 ternary complex
Descriptor: CA14, DB21, cannabidiol
Authors:Cao, S, Zheng, N.
Deposit date:2022-01-04
Release date:2022-01-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Defining molecular glues with a dual-nanobody cannabidiol sensor.
Nat Commun, 13, 2022
7T1Z
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BU of 7t1z by Molmil
Structure of the Fbw7-Skp1-MycNdegron complex
Descriptor: F-box/WD repeat-containing protein 7, Myc proto-oncogene N terminal degron, S-phase kinase-associated protein 1, ...
Authors:Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N.
Deposit date:2021-12-02
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022
7T1Y
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BU of 7t1y by Molmil
Structure of the Fbw7-Skp1-MycCdegron complex
Descriptor: F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, S-phase kinase-associated protein 1, ...
Authors:Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N.
Deposit date:2021-12-02
Release date:2022-02-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022

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