Entry | Database: PDB / ID: 6i9s |
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Title | hRobo2 Extracellular Domains 2-3 |
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Components | Roundabout homolog 2 |
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Keywords | SIGNALING PROTEIN / Slit / Robo / Axon Guidance |
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Function / homology | Function and homology information
olfactory bulb interneuron development / apoptotic process involved in luteolysis / negative regulation of negative chemotaxis / Regulation of cortical dendrite branching / negative regulation of synapse assembly / heart induction / ROBO receptors bind AKAP5 / axon guidance receptor activity / Formation of the ureteric bud / Regulation of commissural axon pathfinding by SLIT and ROBO ...olfactory bulb interneuron development / apoptotic process involved in luteolysis / negative regulation of negative chemotaxis / Regulation of cortical dendrite branching / negative regulation of synapse assembly / heart induction / ROBO receptors bind AKAP5 / axon guidance receptor activity / Formation of the ureteric bud / Regulation of commissural axon pathfinding by SLIT and ROBO / endocardial cushion formation / Signaling by ROBO receptors / pulmonary valve morphogenesis / outflow tract septum morphogenesis / metanephros development / aortic valve morphogenesis / axon midline choice point recognition / aorta development / ureteric bud development / positive regulation of axonogenesis / ventricular septum morphogenesis / retinal ganglion cell axon guidance / positive regulation of Notch signaling pathway / homophilic cell adhesion via plasma membrane adhesion molecules / axolemma / cellular response to hormone stimulus / central nervous system development / axon guidance / cell-cell adhesion / brain development / Regulation of expression of SLITs and ROBOs / chemotaxis / cell surface / extracellular exosome / identical protein binding / plasma membraneSimilarity search - Function Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Fibronectin type-III domain profile. / Fibronectin type III ...Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin V-Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin V-set domain / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like foldSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.48 Å |
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Authors | Barak, R. / Isupov, N.M. / Opatowsky, Y. |
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Funding support | Israel, 1items Organization | Grant number | Country |
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Israel Science Foundation | 182/10 and 1425/15 | Israel |
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Citation | Journal: Cell / Year: 2019 Title: Structural Principles in Robo Activation and Auto-inhibition. Authors: Barak, R. / Yom-Tov, G. / Guez-Haddad, J. / Gasri-Plotnitsky, L. / Maimon, R. / Cohen-Berkman, M. / McCarthy, A.A. / Perlson, E. / Henis-Korenblit, S. / Isupov, M.N. / Opatowsky, Y. |
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History | Deposition | Nov 25, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Mar 13, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 20, 2019 | Group: Data collection / Database references / Category: citation / citation_author / pdbx_database_proc Item: _citation.journal_abbrev / _citation.journal_id_CSD ..._citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Apr 17, 2019 | Group: Data collection / Database references Category: citation / database_PDB_rev / database_PDB_rev_record Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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