+Open data
-Basic information
Entry | Database: PDB / ID: 6bz1 | ||||||
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Title | MEF2 Chimera D83V mutant/DNA complex | ||||||
Components |
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Keywords | TRANSCRIPTION/DNA / MEF2 / Transcription Factor / D83V mutant / conformation switch / TRANSCRIPTION-DNA complex | ||||||
Function / homology | Function and homology information ERK5 cascade / ventricular cardiac myofibril assembly / mitochondrion distribution / cardiac conduction / mitochondrial genome maintenance / dendrite morphogenesis / muscle organ development / histone acetyltransferase binding / Myogenesis / positive regulation of cardiac muscle hypertrophy ...ERK5 cascade / ventricular cardiac myofibril assembly / mitochondrion distribution / cardiac conduction / mitochondrial genome maintenance / dendrite morphogenesis / muscle organ development / histone acetyltransferase binding / Myogenesis / positive regulation of cardiac muscle hypertrophy / ERK/MAPK targets / SMAD binding / cellular response to calcium ion / positive regulation of glucose import / RNA polymerase II transcription regulatory region sequence-specific DNA binding / histone deacetylase binding / cell junction / MAPK cascade / sequence-specific double-stranded DNA binding / heart development / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / transcription regulator complex / sequence-specific DNA binding / RNA polymerase II-specific DNA-binding transcription factor binding / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / protein dimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein heterodimerization activity / DNA-binding transcription factor activity / chromatin binding / DNA-templated transcription / positive regulation of gene expression / chromatin / protein kinase binding / apoptotic process / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.97 Å | ||||||
Authors | Lei, X. / Chen, L. | ||||||
Funding support | United States, 1items
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Citation | Journal: J. Mol. Biol. / Year: 2018 Title: The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B. Authors: Lei, X. / Kou, Y. / Fu, Y. / Rajashekar, N. / Shi, H. / Wu, F. / Xu, J. / Luo, Y. / Chen, L. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6bz1.cif.gz | 213.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6bz1.ent.gz | 171.6 KB | Display | PDB format |
PDBx/mmJSON format | 6bz1.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6bz1_validation.pdf.gz | 467.9 KB | Display | wwPDB validaton report |
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Full document | 6bz1_full_validation.pdf.gz | 473 KB | Display | |
Data in XML | 6bz1_validation.xml.gz | 14.8 KB | Display | |
Data in CIF | 6bz1_validation.cif.gz | 20.6 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/bz/6bz1 ftp://data.pdbj.org/pub/pdb/validation_reports/bz/6bz1 | HTTPS FTP |
-Related structure data
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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