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Yorodumi- PDB-4pti: THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TR... -
+Open data
-Basic information
Entry | Database: PDB / ID: 4pti | |||||||||
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Title | THE GEOMETRY OF THE REACTIVE SITE AND OF THE PEPTIDE GROUPS IN TRYPSIN, TRYPSINOGEN AND ITS COMPLEXES WITH INHIBITORS | |||||||||
Components | TRYPSIN INHIBITOR | |||||||||
Keywords | PROTEINASE INHIBITOR (TRYPSIN) | |||||||||
Function / homology | Function and homology information trypsinogen activation / negative regulation of serine-type endopeptidase activity / sulfate binding / potassium channel inhibitor activity / negative regulation of platelet aggregation / zymogen binding / molecular function inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / serine protease inhibitor complex / serine-type endopeptidase inhibitor activity ...trypsinogen activation / negative regulation of serine-type endopeptidase activity / sulfate binding / potassium channel inhibitor activity / negative regulation of platelet aggregation / zymogen binding / molecular function inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / serine protease inhibitor complex / serine-type endopeptidase inhibitor activity / protease binding / calcium ion binding / extracellular space Similarity search - Function | |||||||||
Biological species | Bos taurus (cattle) | |||||||||
Method | X-RAY DIFFRACTION / Resolution: 1.5 Å | |||||||||
Authors | Huber, R. / Kukla, D. / Ruehlmann, A. / Epp, O. / Formanek, H. / Deisenhofer, J. / Steigemann, W. | |||||||||
Citation | Journal: Acta Crystallogr.,Sect.B / Year: 1983 Title: The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors Authors: Marquart, M. / Walter, J. / Deisenhofer, J. / Bode, W. / Huber, R. #1: Journal: J.Mol.Biol. / Year: 1987 Title: Comparison of Two Highly Refined Structures of Bovine Pancreatic Trypsin Inhibitor Authors: Wlodawer, A. / Deisenhofer, J. / Huber, R. #2: Journal: Acta Crystallogr.,Sect.B / Year: 1975 Title: Crystallographic Refinement of the Structure of Bovine Pancreatic Trypsin Inhibitor at 1.5 Angstroms Resolution Authors: Deisenhofer, J. / Steigemann, W. #3: Journal: Bayer Symp. / Year: 1974 Title: The Model of the Basic Pancreatic Trypsin Inhibitor Refined at 1.5 Angstroms Resolution Authors: Deisenhofer, J. / Steigemann, W. #4: Journal: Cold Spring Harbor Symp.Quant.Biol. / Year: 1972 Title: Pancreatic Trypsin Inhibitor (Kunitz). Part I. Structure and Function Authors: Huber, R. / Kukla, D. / Ruehlmann, A. / Steigemann, W. #5: Journal: Cold Spring Harbor Symp.Quant.Biol. / Year: 1972 Title: Pancreatic Trypsin Inhibitor (Kunitz). Part II. Complexes with Proteinases Authors: Ruehlmann, A. / Schramm, H.J. / Kukla, D. / Huber, R. #6: Journal: Naturwissenschaften / Year: 1970 Title: The Basic Trypsin Inhibitor of Bovine Pancreas. I. Structure Analysis and Conformation of the Polypeptide Chain Authors: Huber, R. / Kukla, D. / Ruehlmann, A. / Epp, O. / Formanek, H. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 4pti.cif.gz | 19.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb4pti.ent.gz | 15.2 KB | Display | PDB format |
PDBx/mmJSON format | 4pti.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pt/4pti ftp://data.pdbj.org/pub/pdb/validation_reports/pt/4pti | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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Unit cell |
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-Components
#1: Protein | Mass: 6527.568 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Bos taurus (cattle) / References: UniProt: P00974 |
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#2: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
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-Sample preparation
Crystal | Density Matthews: 1.84 Å3/Da / Density % sol: 33.01 % |
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Crystal grow | *PLUS Method: unknown |
-Processing
Refinement | Resolution: 1.5→7 Å / Rfactor Rwork: 0.162 | ||||||||||||
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Refinement step | Cycle: LAST / Resolution: 1.5→7 Å
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