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Yorodumi- PDB-1l8c: STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR H... -
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-Basic information
Entry | Database: PDB / ID: 1l8c | ||||||
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Title | STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE | ||||||
Components |
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Keywords | GENE REGULATION | ||||||
Function / homology | Function and homology information epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / iris morphogenesis / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / positive regulation of chemokine-mediated signaling pathway / hypoxia-inducible factor-1alpha signaling pathway / Attenuation phase ...epithelial cell differentiation involved in mammary gland alveolus development / neural fold elevation formation / iris morphogenesis / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / positive regulation of chemokine-mediated signaling pathway / hypoxia-inducible factor-1alpha signaling pathway / Attenuation phase / Regulation of gene expression by Hypoxia-inducible Factor / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / glandular epithelial cell maturation / Transcriptional and post-translational regulation of MITF-M expression and activity / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cAMP response element binding protein binding / elastin metabolic process / Formation of the beta-catenin:TCF transactivating complex / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / regulation of transforming growth factor beta2 production / Notch-HLH transcription pathway / connective tissue replacement involved in inflammatory response wound healing / cardiac ventricle morphogenesis / negative regulation of mesenchymal cell apoptotic process / hemoglobin biosynthetic process / PTK6 promotes HIF1A stabilization / digestive tract morphogenesis / positive regulation of hormone biosynthetic process / positive regulation of cell adhesion molecule production / germ-line stem cell population maintenance / mesenchymal cell apoptotic process / retina vasculature development in camera-type eye / Cellular response to hypoxia / intestinal epithelial cell maturation / positive regulation of mitophagy / negative regulation of growth / regulation of protein neddylation / negative regulation of viral process / Regulation of lipid metabolism by PPARalpha / collagen metabolic process / PTK6 Expression / negative regulation of bone mineralization / intracellular oxygen homeostasis / Cytoprotection by HMOX1 / B-1 B cell homeostasis / vascular endothelial growth factor production / CD209 (DC-SIGN) signaling / Estrogen-dependent gene expression / peptide lactyltransferase (CoA-dependent) activity / outer kinetochore / negative regulation of interferon-beta production / transcription regulator activator activity / E-box binding / negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / dopaminergic neuron differentiation / lactate metabolic process / STAT3 nuclear events downstream of ALK signaling / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / positive regulation of cytokine production involved in inflammatory response / histone H3K27 acetyltransferase activity / negative regulation of thymocyte apoptotic process / MRF binding / motile cilium / positive regulation of vascular endothelial growth factor receptor signaling pathway / negative regulation of TOR signaling / positive regulation of signaling receptor activity / insulin secretion involved in cellular response to glucose stimulus / peroxisome proliferator activated receptor binding / response to iron ion / response to muscle activity / face morphogenesis / neural crest cell migration / Regulation of gene expression by Hypoxia-inducible Factor / regulation of glycolytic process / embryonic hemopoiesis / negative regulation of transcription by RNA polymerase I / embryonic placenta development / peptide-lysine-N-acetyltransferase activity / DNA-binding transcription repressor activity / DNA-binding transcription activator activity / regulation of aerobic respiration / cellular response to hepatocyte growth factor stimulus / positive regulation of G1/S transition of mitotic cell cycle / muscle cell cellular homeostasis / positive regulation of neuroblast proliferation / positive regulation of dendritic spine development / positive regulation of epithelial cell migration / axonal transport of mitochondrion / bone mineralization / heart looping / outflow tract morphogenesis / intracellular glucose homeostasis / SMAD binding / acetyltransferase activity / positive regulation of insulin secretion involved in cellular response to glucose stimulus / behavioral response to cocaine / TFIIB-class transcription factor binding / histone acetyltransferase complex Similarity search - Function | ||||||
Biological species | Mus musculus (house mouse) Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Dames, S.A. / Martinez-Yamout, M. / De Guzman, R.N. / Dyson, H.J. / Wright, P.E. | ||||||
Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2002 Title: Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Authors: Dames, S.A. / Martinez-Yamout, M. / De Guzman, R.N. / Dyson, H.J. / Wright, P.E. | ||||||
History |
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Remark 999 | SEQEUNCE AUTHOR STATES RESIDUE GLY56 IS A SEQUENCE VARIANT |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1l8c.cif.gz | 888 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1l8c.ent.gz | 744.9 KB | Display | PDB format |
PDBx/mmJSON format | 1l8c.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1l8c_validation.pdf.gz | 366.8 KB | Display | wwPDB validaton report |
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Full document | 1l8c_full_validation.pdf.gz | 584.6 KB | Display | |
Data in XML | 1l8c_validation.xml.gz | 39.7 KB | Display | |
Data in CIF | 1l8c_validation.cif.gz | 72 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/l8/1l8c ftp://data.pdbj.org/pub/pdb/validation_reports/l8/1l8c | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 10853.724 Da / Num. of mol.: 1 Fragment: TAZ1 (Transcription activation zinc finger) domain, Residues 345-439 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli (E. coli) / References: UniProt: P45481 |
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#2: Protein | Mass: 5565.170 Da / Num. of mol.: 1 Fragment: CTAD (C-Terminal activation) domain, Residues 776-826 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli) / References: UniProt: Q16665 |
#3: Chemical |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details |
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Sample conditions | Ionic strength: 2.0 Millimolar / pH: 6.1 / Pressure: Ambient / Temperature: 298 K | ||||||||
Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M | |||||||||||||||
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Radiation wavelength | Relative weight: 1 | |||||||||||||||
NMR spectrometer |
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-Processing
NMR software |
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Refinement | Software ordinal: 1 / Details: PEARLMAN, D.A. ET AL. (1995) COMP. PHYS.COMMU. | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the least restraint violations, structures with the lowest energy Conformers calculated total number: 200 / Conformers submitted total number: 20 |