登録情報 | データベース: PDB / ID: 6wly |
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タイトル | PAK4 kinase domain in complex with LIMK1 Thr508 substrate peptide |
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要素 | - LIM Kinase 1 peptide
- Serine/threonine-protein kinase PAK 4
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キーワード | TRANSFERASE (転移酵素) / serine/threonine kinase PAK4 / LIM kinase 1 / LIMK1 / phosphopeptide / Thr508 |
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機能・相同性 | 機能・相同性情報
positive regulation of actin filament bundle assembly / dendritic spine development / cadherin binding involved in cell-cell adhesion / negative regulation of ubiquitin-protein transferase activity / RHO GTPases Activate ROCKs / axon extension / Sema4D induced cell migration and growth-cone collapse / Activation of RAC1 / RHOV GTPase cycle / Fc-gamma receptor signaling pathway involved in phagocytosis ...positive regulation of actin filament bundle assembly / dendritic spine development / cadherin binding involved in cell-cell adhesion / negative regulation of ubiquitin-protein transferase activity / RHO GTPases Activate ROCKs / axon extension / Sema4D induced cell migration and growth-cone collapse / Activation of RAC1 / RHOV GTPase cycle / Fc-gamma receptor signaling pathway involved in phagocytosis / stress fiber assembly / RHOJ GTPase cycle / RHOQ GTPase cycle / RHO GTPases activate PAKs / regulation of MAPK cascade / RHOH GTPase cycle / CDC42 GTPase cycle / RHOU GTPase cycle / Rho protein signal transduction / Sema3A PAK dependent Axon repulsion / RHOG GTPase cycle / cellular response to organic cyclic compound / RAC2 GTPase cycle / RAC3 GTPase cycle / positive regulation of axon extension / negative regulation of endothelial cell apoptotic process / positive regulation of stress fiber assembly / cytoskeleton organization / EPHB-mediated forward signaling / RAC1 GTPase cycle / heat shock protein binding / male germ cell nucleus / regulation of cell growth / 接着結合 / Regulation of actin dynamics for phagocytic cup formation / positive regulation of angiogenesis / 遊走 / lamellipodium / nervous system development / actin cytoskeleton organization / 細胞骨格 / non-specific serine/threonine protein kinase / protein kinase activity / neuron projection / intracellular signal transduction / nuclear speck / 細胞周期 / リン酸化 / protein phosphorylation / focal adhesion / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / ゴルジ体 / シグナル伝達 / ATP binding / 生体膜 / metal ion binding / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type ...p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / PDZドメイン / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZドメイン / PDZ superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Serine/threonine-protein kinase PAK 4 / LIM domain kinase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Chetty, A.K. / Ha, B.H. / Boggon, T.J. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM102262 | 米国 | American Heart Association | 19IPLOI34740007 | 米国 |
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引用 | ジャーナル: J.Struct.Biol. / 年: 2020 タイトル: Recognition of physiological phosphorylation sites by p21-activated kinase 4. 著者: Chetty, A.K. / Sexton, J.A. / Ha, B.H. / Turk, B.E. / Boggon, T.J. |
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履歴 | 登録 | 2020年4月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年6月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年7月8日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.page_first / _citation.page_last ..._citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2020年8月12日 | Group: Database references / カテゴリ: citation / citation_author / Item: _citation.journal_volume / _citation_author.name |
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改定 1.3 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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