登録情報 | データベース: PDB / ID: 5oj6 |
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タイトル | Crystal structure of the chicken MDGA1 ectodomain in complex with the human neuroligin 1 (NL1(-A-B)) cholinesterase domain. |
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要素 | - MAM domain-containing glycosylphosphatidylinositol anchor protein 1
- Neuroligin-1
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キーワード | CELL ADHESION / neuroligin-neurexin / synapse formation / austism spectrum disorders (ASDs) / synaptic transmission |
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機能・相同性 | 機能・相同性情報
neurexin clustering involved in presynaptic membrane assembly / asymmetric, glutamatergic, excitatory synapse / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / terminal button organization / neuron to neuron synapse / positive regulation of synaptic vesicle exocytosis ...neurexin clustering involved in presynaptic membrane assembly / asymmetric, glutamatergic, excitatory synapse / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / terminal button organization / neuron to neuron synapse / positive regulation of synaptic vesicle exocytosis / neuronal signal transduction / excitatory synapse assembly / postsynaptic density protein 95 clustering / negative regulation of dendritic spine morphogenesis / postsynaptic membrane assembly / presynaptic membrane assembly / synapse maturation / maintenance of synapse structure / inhibitory synapse / synaptic vesicle clustering / synaptic vesicle targeting / neuron cell-cell adhesion / neurexin family protein binding / presynapse assembly / filopodium tip / receptor localization to synapse / protein localization to synapse / NMDA glutamate receptor clustering / neuron projection arborization / positive regulation of synaptic vesicle endocytosis / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / AMPA glutamate receptor clustering / regulation of AMPA receptor activity / Neurexins and neuroligins / positive regulation of synapse assembly / positive regulation of ruffle assembly / regulation of NMDA receptor activity / postsynaptic specialization membrane / positive regulation of intracellular signal transduction / positive regulation of filopodium assembly / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of neuron differentiation / positive regulation of dendritic spine development / positive regulation of excitatory postsynaptic potential / synaptic vesicle endocytosis / excitatory synapse / GABA-ergic synapse / protein targeting / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis / synaptic cleft / cell adhesion molecule binding / synapse assembly / cellular response to calcium ion / positive regulation of synaptic transmission, GABAergic / PDZ domain binding / neuron migration / modulation of chemical synaptic transmission / establishment of protein localization / neuromuscular junction / positive regulation of neuron projection development / rhythmic process / neuron projection development / presynapse / signaling receptor activity / nervous system development / amyloid-beta binding / scaffold protein binding / chemical synaptic transmission / postsynaptic membrane / postsynapse / receptor complex / dendritic spine / postsynaptic density / glutamatergic synapse / synapse / dendrite / cell surface / Golgi apparatus / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Neuroligin / Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) / MAM domain, meprin/A5/mu / MAM domain / MAM domain profile. / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / Immunoglobulin domain ...Neuroligin / Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) / MAM domain, meprin/A5/mu / MAM domain / MAM domain profile. / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / Immunoglobulin domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Alpha/Beta hydrolase fold, catalytic domain / Concanavalin A-like lectin/glucanase domain superfamily / Alpha/Beta hydrolase fold / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 MAM domain-containing glycosylphosphatidylinositol anchor protein 1 / Neuroligin-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Gallus gallus (ニワトリ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.3 Å |
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データ登録者 | Elegheert, J. / Clayton, A.J. / Aricescu, A.R. |
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資金援助 | 英国, カナダ, 米国, 13件 組織 | 認可番号 | 国 |
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Medical Research Council (United Kingdom) | G0700232 | 英国 | Medical Research Council (United Kingdom) | L009609 | 英国 | Medical Research Council (United Kingdom) | MC_UP_1201/15 | 英国 | CIHR | FDN- 143206 | カナダ | CIHR | NDD-144222 | カナダ | National Institutes of Health | R00 DC013805 | 米国 | European Molecular Biology Organization | ALTF 1116-2012 | 英国 | Marie Curie | FP7-328531 | 英国 | Cancer Research UK | C375/A10976 | 英国 | National Institutes of Health | MH085926 | 米国 | National Institutes of Health | GM105730 | 米国 | National Institutes of Health | F32NS093753 | 米国 | Wellcome Trust | 090532/Z/09/Z | 英国 |
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引用 | ジャーナル: Neuron / 年: 2017 タイトル: Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins. 著者: Elegheert, J. / Cvetkovska, V. / Clayton, A.J. / Heroven, C. / Vennekens, K.M. / Smukowski, S.N. / Regan, M.C. / Jia, W. / Smith, A.C. / Furukawa, H. / Savas, J.N. / de Wit, J. / Begbie, J. / ...著者: Elegheert, J. / Cvetkovska, V. / Clayton, A.J. / Heroven, C. / Vennekens, K.M. / Smukowski, S.N. / Regan, M.C. / Jia, W. / Smith, A.C. / Furukawa, H. / Savas, J.N. / de Wit, J. / Begbie, J. / Craig, A.M. / Aricescu, A.R. |
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履歴 | 登録 | 2017年7月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年8月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年8月30日 | Group: Database references / カテゴリ: citation Item: _citation.journal_id_ISSN / _citation.page_last ..._citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2017年9月20日 | Group: Database references / カテゴリ: struct_ref_seq_dif / Item: _struct_ref_seq_dif.details |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2024年1月17日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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