Entry Database : PDB / ID : 5ojk Structure visualization Downloads & linksTitle Crystal structure of the human neuroligin 1 cholinesterase domain containing spliced sequence B (SSB) (NL1(-A+B)) ComponentsNeuroligin-1,Neuroligin-1 Details Keywords CELL ADHESION / neuroligin-neurexin / synaptic organizer protein / spliced sequence BFunction / homology Function and homology informationFunction Domain/homology Component
neurexin clustering involved in presynaptic membrane assembly / asymmetric, glutamatergic, excitatory synapse / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / terminal button organization / neuron to neuron synapse / positive regulation of synaptic vesicle exocytosis ... neurexin clustering involved in presynaptic membrane assembly / asymmetric, glutamatergic, excitatory synapse / cytoskeletal matrix organization at active zone / cell-cell adhesion involved in synapse maturation / positive regulation of circadian sleep/wake cycle, wakefulness / protein complex involved in cell-cell adhesion / positive regulation of neuromuscular synaptic transmission / terminal button organization / neuron to neuron synapse / positive regulation of synaptic vesicle exocytosis / neuronal signal transduction / excitatory synapse assembly / postsynaptic density protein 95 clustering / negative regulation of dendritic spine morphogenesis / postsynaptic membrane assembly / synapse maturation / presynaptic membrane assembly / maintenance of synapse structure / synaptic vesicle targeting / inhibitory synapse / synaptic vesicle clustering / neuron cell-cell adhesion / presynapse assembly / neurexin family protein binding / filopodium tip / receptor localization to synapse / protein localization to synapse / NMDA glutamate receptor clustering / neuron projection arborization / positive regulation of synaptic vesicle endocytosis / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of AMPA receptor activity / AMPA glutamate receptor clustering / postsynaptic specialization membrane / Neurexins and neuroligins / positive regulation of synapse assembly / positive regulation of ruffle assembly / regulation of NMDA receptor activity / positive regulation of intracellular signal transduction / positive regulation of filopodium assembly / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / regulation of neuron differentiation / positive regulation of dendritic spine development / positive regulation of excitatory postsynaptic potential / excitatory synapse / synaptic vesicle endocytosis / GABA-ergic synapse / protein targeting / synaptic cleft / cell adhesion molecule binding / synapse assembly / cellular response to calcium ion / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis / PDZ domain binding / positive regulation of synaptic transmission, GABAergic / modulation of chemical synaptic transmission / establishment of protein localization / neuromuscular junction / positive regulation of neuron projection development / neuron projection development / rhythmic process / presynapse / nervous system development / signaling receptor activity / amyloid-beta binding / scaffold protein binding / postsynapse / chemical synaptic transmission / postsynaptic membrane / dendritic spine / postsynaptic density / receptor complex / glutamatergic synapse / synapse / dendrite / Golgi apparatus / cell surface / identical protein binding / membrane / plasma membrane Similarity search - Function Neuroligin / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase, type B / Carboxylesterase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.55 Å DetailsAuthors Elegheert, J. / Aricescu, A.R. Funding support United Kingdom, Canada, United States, 13items Details Hide detailsOrganization Grant number Country Medical Research Council (United Kingdom) G0700232 United Kingdom Medical Research Council (United Kingdom) L009609 United Kingdom Medical Research Council (United Kingdom) MC_UP_1201/15 United Kingdom CIHR FDN-143206 Canada CIHR NDD-144222 Canada National Institutes of Health R00 DC013805 United States European Molecular Biology Organization ALTF 1116-2012 United Kingdom Marie Curie FP7-328531 United Kingdom Cancer Research UK C375/A10976 United Kingdom National Institutes of Health MH085926 United States National Institutes of Health GM105730 United States National Institutes of Health F32NS093753 United States Wellcome Trust 090532/Z/09/Z United Kingdom
CitationJournal : Neuron / Year : 2017Title : Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.Authors: Elegheert, J. / Cvetkovska, V. / Clayton, A.J. / Heroven, C. / Vennekens, K.M. / Smukowski, S.N. / Regan, M.C. / Jia, W. / Smith, A.C. / Furukawa, H. / Savas, J.N. / de Wit, J. / Begbie, J. ... Authors : Elegheert, J. / Cvetkovska, V. / Clayton, A.J. / Heroven, C. / Vennekens, K.M. / Smukowski, S.N. / Regan, M.C. / Jia, W. / Smith, A.C. / Furukawa, H. / Savas, J.N. / de Wit, J. / Begbie, J. / Craig, A.M. / Aricescu, A.R. History Deposition Jul 21, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 23, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Aug 30, 2017 Group : Database references / Category : citationItem : _citation.journal_id_ISSN / _citation.page_last ... _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title Revision 1.2 Jan 31, 2018 Group : Structure summary / Category : audit_author / Item : _audit_author.nameRevision 1.3 Jul 29, 2020 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 1.4 Jan 17, 2024 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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