+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 5gse | ||||||||||||||||||
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タイトル | Crystal structure of unusual nucleosome | ||||||||||||||||||
要素 |
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キーワード | STRUCTURAL PROTEIN/DNA (構造) / histone-fold / DNA-binding / nucleus (細胞核) / STRUCTURAL PROTEIN-DNA complex (構造) | ||||||||||||||||||
機能・相同性 | 機能・相同性情報 negative regulation of tumor necrosis factor-mediated signaling pathway / negative regulation of megakaryocyte differentiation / protein localization to CENP-A containing chromatin / Chromatin modifying enzymes / Replacement of protamines by nucleosomes in the male pronucleus / CENP-A containing nucleosome / epigenetic regulation of gene expression / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine ...negative regulation of tumor necrosis factor-mediated signaling pathway / negative regulation of megakaryocyte differentiation / protein localization to CENP-A containing chromatin / Chromatin modifying enzymes / Replacement of protamines by nucleosomes in the male pronucleus / CENP-A containing nucleosome / epigenetic regulation of gene expression / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Deposition of new CENPA-containing nucleosomes at the centromere / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Inhibition of DNA recombination at telomere / Meiotic synapsis / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / SUMOylation of chromatin organization proteins / Assembly of the ORC complex at the origin of replication / DNAメチル化 / Condensation of Prophase Chromosomes / HCMV Late Events / Chromatin modifications during the maternal to zygotic transition (MZT) / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / SIRT1 negatively regulates rRNA expression / innate immune response in mucosa / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Nonhomologous End-Joining (NHEJ) / lipopolysaccharide binding / Transcriptional regulation by small RNAs / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / NoRC negatively regulates rRNA expression / G2/M DNA damage checkpoint / B-WICH complex positively regulates rRNA expression / HDMs demethylate histones / DNA Damage/Telomere Stress Induced Senescence / Metalloprotease DUBs / PKMTs methylate histone lysines / RMTs methylate histone arginines / 遺伝的組換え / Pre-NOTCH Transcription and Translation / nucleosome assembly / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / UCH proteinases / ヌクレオソーム / antimicrobial humoral immune response mediated by antimicrobial peptide / E3 ubiquitin ligases ubiquitinate target proteins / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / 遺伝子発現 / RUNX1 regulates transcription of genes involved in differentiation of HSCs / chromatin organization / Factors involved in megakaryocyte development and platelet production / Processing of DNA double-strand break ends / HATs acetylate histones / antibacterial humoral response / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / killing of cells of another organism / Estrogen-dependent gene expression / defense response to Gram-negative bacterium / chromosome, telomeric region / Ub-specific processing proteases / defense response to Gram-positive bacterium / cadherin binding / Amyloid fiber formation / protein heterodimerization activity / negative regulation of cell population proliferation / protein-containing complex / DNA binding / extracellular space / RNA binding / extracellular exosome / extracellular region / 核質 / 生体膜 / 細胞核 / 細胞質基質 類似検索 - 分子機能 | ||||||||||||||||||
生物種 | Homo sapiens (ヒト) synthetic construct (人工物) | ||||||||||||||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.14 Å | ||||||||||||||||||
データ登録者 | Kato, D. / Osakabe, A. / Arimura, Y. / Park, S.Y. / Kurumizaka, H. | ||||||||||||||||||
資金援助 | 日本, 5件
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引用 | ジャーナル: Science / 年: 2017 タイトル: Crystal structure of the overlapping dinucleosome composed of hexasome and octasome 著者: Kato, D. / Osakabe, A. / Arimura, Y. / Mizukami, Y. / Horikoshi, N. / Saikusa, K. / Akashi, S. / Nishimura, Y. / Park, S.Y. / Nogami, J. / Maehara, K. / Ohkawa, Y. / Matsumoto, A. / Kono, H. ...著者: Kato, D. / Osakabe, A. / Arimura, Y. / Mizukami, Y. / Horikoshi, N. / Saikusa, K. / Akashi, S. / Nishimura, Y. / Park, S.Y. / Nogami, J. / Maehara, K. / Ohkawa, Y. / Matsumoto, A. / Kono, H. / Inoue, R. / Sugiyama, M. / Kurumizaka, H. | ||||||||||||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 5gse.cif.gz | 537.5 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb5gse.ent.gz | 406.9 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 5gse.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/gs/5gse ftp://data.pdbj.org/pub/pdb/validation_reports/gs/5gse | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
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