登録情報 | データベース: PDB / ID: 4km5 |
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タイトル | X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS) |
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要素 | Cyclic GMP-AMP synthase |
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キーワード | TRANSFERASE (転移酵素) / DNA Sensor / Innate Immunity (自然免疫系) / Zinc Finger (ジンクフィンガー) / Nucleotidyl Transferase / DNA (デオキシリボ核酸) / Cytoplasmic (細胞質) |
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機能・相同性 | 機能・相同性情報
cyclic GMP-AMP synthase / 2',3'-cyclic GMP-AMP synthase activity / STING mediated induction of host immune responses / 傍分泌 / poly-ADP-D-ribose modification-dependent protein binding / cGAS/STING signaling pathway / regulation of immunoglobulin production / regulation of T cell activation / pattern recognition receptor signaling pathway / negative regulation of double-strand break repair via homologous recombination ...cyclic GMP-AMP synthase / 2',3'-cyclic GMP-AMP synthase activity / STING mediated induction of host immune responses / 傍分泌 / poly-ADP-D-ribose modification-dependent protein binding / cGAS/STING signaling pathway / regulation of immunoglobulin production / regulation of T cell activation / pattern recognition receptor signaling pathway / negative regulation of double-strand break repair via homologous recombination / negative regulation of cGAS/STING signaling pathway / cellular response to exogenous dsRNA / cytoplasmic pattern recognition receptor signaling pathway / cGMP-mediated signaling / cAMP-mediated signaling / nucleosome binding / positive regulation of type I interferon production / positive regulation of defense response to virus by host / phosphatidylinositol-4,5-bisphosphate binding / activation of innate immune response / molecular condensate scaffold activity / determination of adult lifespan / positive regulation of cellular senescence / site of double-strand break / double-stranded DNA binding / defense response to virus / nuclear body / DNA修復 / 自然免疫系 / DNA damage response / chromatin binding / GTP binding / protein homodimerization activity / DNA binding / 核質 / ATP binding / metal ion binding / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Beta Polymerase; domain 2 - #90 / Poly(a)-polymerase, middle domain - #40 / Poly(a)-polymerase, middle domain / Mab-21-like, nucleotidyltransferase domain / Mab-21-like, HhH/H2TH-like domain / Mab-21 protein HhH/H2TH-like domain / Mab-21 protein nucleotidyltransferase domain / Mab-21-like / Mab-21 / Beta Polymerase; domain 2 ...Beta Polymerase; domain 2 - #90 / Poly(a)-polymerase, middle domain - #40 / Poly(a)-polymerase, middle domain / Mab-21-like, nucleotidyltransferase domain / Mab-21-like, HhH/H2TH-like domain / Mab-21 protein HhH/H2TH-like domain / Mab-21 protein nucleotidyltransferase domain / Mab-21-like / Mab-21 / Beta Polymerase; domain 2 / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 2.499 Å |
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データ登録者 | Kranzusch, P.J. / Lee, A.S.Y. / Berger, J.M. / Doudna, J.A. |
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引用 | ジャーナル: Cell Rep / 年: 2013 タイトル: Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity. 著者: Kranzusch, P.J. / Lee, A.S. / Berger, J.M. / Doudna, J.A. |
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履歴 | 登録 | 2013年5月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年5月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年6月12日 | Group: Database references |
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改定 1.2 | 2017年11月15日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.3 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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