登録情報 | データベース: EMDB / ID: EMD-30816 |
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タイトル | Cryo-EM structure of SARS-CoV2 RBD-ACE2 complex |
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マップデータ | |
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試料 | - 複合体: Cryo-EM structure of SARS-CoV2 RBD-ACE2 complex
- 複合体: ACE2アンジオテンシン変換酵素2
- タンパク質・ペプチド: Angiotensin-converting enzyme 2アンジオテンシン変換酵素2
- 複合体: SARS-CoV2 RBD
- タンパク質・ペプチド: Spike glycoproteinスパイクタンパク質
- リガンド: ZINC ION
- リガンド: CHLORIDE ION塩化物
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
- リガンド: water水
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機能・相同性 | 機能・相同性情報
positive regulation of amino acid transport / アンジオテンシン変換酵素2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / tryptophan transport / positive regulation of gap junction assembly / regulation of systemic arterial blood pressure by renin-angiotensin / regulation of vasoconstriction / regulation of cardiac conduction ...positive regulation of amino acid transport / アンジオテンシン変換酵素2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / tryptophan transport / positive regulation of gap junction assembly / regulation of systemic arterial blood pressure by renin-angiotensin / regulation of vasoconstriction / regulation of cardiac conduction / peptidyl-dipeptidase activity / angiotensin maturation / maternal process involved in female pregnancy / Metabolism of Angiotensinogen to Angiotensins / metallocarboxypeptidase activity / Attachment and Entry / carboxypeptidase activity / negative regulation of signaling receptor activity / positive regulation of cardiac muscle contraction / regulation of cytokine production / ウイルスのライフサイクル / blood vessel diameter maintenance / regulation of transmembrane transporter activity / brush border membrane / negative regulation of smooth muscle cell proliferation / 繊毛 / negative regulation of ERK1 and ERK2 cascade / endocytic vesicle membrane / metallopeptidase activity / positive regulation of reactive oxygen species metabolic process / virus receptor activity / regulation of cell population proliferation / regulation of inflammatory response / Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / endopeptidase activity / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / Potential therapeutics for SARS / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / symbiont entry into host cell / 脂質ラフト / apical plasma membrane / fusion of virus membrane with host plasma membrane / 小胞体 / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / 細胞膜 / extracellular space / extracellular exosome / zinc ion binding / extracellular region / 生体膜 / identical protein binding / 細胞膜類似検索 - 分子機能 Collectrin-like domain profile. / Collectrin domain / Renal amino acid transporter / Peptidase family M2 domain profile. / Peptidase M2, peptidyl-dipeptidase A / アンジオテンシン変換酵素 / Neutral zinc metallopeptidases, zinc-binding region signature. / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. ...Collectrin-like domain profile. / Collectrin domain / Renal amino acid transporter / Peptidase family M2 domain profile. / Peptidase M2, peptidyl-dipeptidase A / アンジオテンシン変換酵素 / Neutral zinc metallopeptidases, zinc-binding region signature. / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) / Severe acute respiratory syndrome coronavirus 2 (SARSコロナウイルス2) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.8 Å |
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データ登録者 | Wang J / Lan J / Wang XQ / Wang HW |
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引用 | ジャーナル: Biophys Rep / 年: 2022 タイトル: Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM 著者: Liu N / Zheng LM / Xu J / Wang J / Hu CX / Lan J / Zhang X / Zhang JC / Xu K / Cheng H / Yang Z / Gao X / Wang XQ / Peng HL / Chen YN / Wang HW |
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履歴 | 登録 | 2020年12月22日 | - |
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ヘッダ(付随情報) 公開 | 2021年12月29日 | - |
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マップ公開 | 2021年12月29日 | - |
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更新 | 2022年7月13日 | - |
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現状 | 2022年7月13日 | 処理サイト: PDBj / 状態: 公開 |
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