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- SASDBQ3: Middle East Respiratory Syndrome (MERS) coronavirus nucleocapsid ... -
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Open data
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Basic information
Entry | Database: SASBDB / ID: SASDBQ3 |
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![]() | Middle East Respiratory Syndrome (MERS) coronavirus nucleocapsid N-Protein (N-terminal domain 1-164)
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Function / homology | ![]() |
Biological species | ![]() ![]() |
![]() | ![]() Title: Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering. Authors: Nicolas Papageorgiou / Julie Lichière / Amal Baklouti / François Ferron / Marion Sévajol / Bruno Canard / Bruno Coutard / ![]() Abstract: The N protein of coronaviruses is a multifunctional protein that is organized into several domains. The N-terminal part is composed of an intrinsically disordered region (IDR) followed by a ...The N protein of coronaviruses is a multifunctional protein that is organized into several domains. The N-terminal part is composed of an intrinsically disordered region (IDR) followed by a structured domain called the N-terminal domain (NTD). In this study, the structure determination of the N-terminal region of the MERS-CoV N protein via X-ray diffraction measurements is reported at a resolution of 2.4 Å. Since the first 30 amino acids were not resolved by X-ray diffraction, the structural study was completed by a SAXS experiment to propose a structural model including the IDR. This model presents the N-terminal region of the MERS-CoV as a monomer that displays structural features in common with other coronavirus NTDs. |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
-Models
Model #453 | ![]() Type: dummy / Software: DAMMIF (r4556) / Radius of dummy atoms: 1.70 A / Chi-square value: 0.408 / P-value: 0.015000 ![]() |
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Model #454 | ![]() Type: mix / Software: EOM / Radius of dummy atoms: 1.90 A / Chi-square value: 0.509 ![]() |
Model #455 | ![]() Type: mix / Software: EOM / Radius of dummy atoms: 1.90 A / Chi-square value: 0.509 ![]() |
Model #456 | ![]() Type: mix / Software: EOM / Radius of dummy atoms: 1.90 A / Chi-square value: 0.509 ![]() |
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Sample
![]() | Name: Middle East Respiratory Syndrome (MERS) coronavirus nucleocapsid N-Protein (N-terminal domain 1-164) Specimen concentration: 0.21-3.06 |
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Buffer | Name: HEPES / Concentration: 10.00 mM / pH: 7.5 / Composition: 300 mM NaCl |
Entity #303 | Name: MERS N-Protein / Type: protein Description: Middle East Respiratory Syndrome (MERS) coronavirus nucleocapsid N-Protein (N-terminal domain 1-164) Formula weight: 17.788 / Num. of mol.: 1 / Source: Middle East respiratory syndrome coronavirus / References: UniProt: T2B9R0 Sequence: MASPAAPRAV SFADNNDITN TNLSRGRGRN PKPRAAPNNT VSWYTGLTQH GKVPLTFPPG QGVPLNANST PAQNAGYWRR QDRKINTGNG IKQLAPRWYF YYTGTGPEAA LPFRAVKDGI VWVHEDGATD APSTFGTRNP NNDSAIVTQF APGTKLPKNF HIEG |
-Experimental information
Beam | Instrument name: ESRF BM29 / City: Grenoble / 国: France ![]() | |||||||||||||||||||||||||||
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Detector | Name: Pilatus 1M | |||||||||||||||||||||||||||
Scan |
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Distance distribution function P(R) |
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Result |
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