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- SASDD75: 'TG'-interacting factor homeodomain in solution (Homeobox protein... -

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Basic information

Entry
Database: SASBDB / ID: SASDD75
Sample'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1)
  • Homeobox protein TGIF1 (protein), TGIF, Homo sapiens
Function / homology
Function and homology information


co-SMAD binding / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / cellular response to growth factor stimulus / DNA-binding transcription repressor activity, RNA polymerase II-specific / sequence-specific double-stranded DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / response to xenobiotic stimulus / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity ...co-SMAD binding / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / cellular response to growth factor stimulus / DNA-binding transcription repressor activity, RNA polymerase II-specific / sequence-specific double-stranded DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / response to xenobiotic stimulus / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / chromatin / negative regulation of transcription by RNA polymerase II / nucleoplasm
Similarity search - Function
Homeobox KN domain / Homeobox KN domain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeobox-like domain superfamily
Similarity search - Domain/homology
Homeobox protein TGIF1
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Ewelina Guca (Institute for Research in Biomedicine in Barcelona)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Models

Model #1826
Type: dummy / Radius of dummy atoms: 2.25 A / Symmetry: P1 / Chi-square value: 1.123 / P-value: 0.657170
Search similar-shape structures of this assembly by Omokage search (details)
Model #1828
Type: atomic / Symmetry: P1
Comment: Two monomers (B) and (D) have been used as rigid bodies and N- and C-terminal loops were modelled.
Chi-square value: 1.721
Search similar-shape structures of this assembly by Omokage search (details)
Model #1833
Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.116 / P-value: 0.198541
Search similar-shape structures of this assembly by Omokage search (details)
Model #1835
Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.116 / P-value: 0.198541
Search similar-shape structures of this assembly by Omokage search (details)
Model #1836
Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.116 / P-value: 0.198541
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: 'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1)
Specimen concentration: 6 mg/ml
BufferName: 20 mM Tris, 150 mM NaCl / pH: 7.4
Entity #986Name: TGIF / Type: protein / Description: Homeobox protein TGIF1 / Formula weight: 10.68 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: Q15583
Sequence:
GPDIPLDLSS SAGSGKRRRR GNLPKESVQI LRDWLYEHRY NAYPSEQEKA LLSQQTHLST LQVCNWFINA RRRLLPDMLR KDGKDPNQFT IS

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Experimental information

BeamInstrument name: PETRA III P12 / City: Hamburg / 国: Germany / Type of source: X-ray synchrotronSynchrotron / Wavelength: 0.124 Å / Dist. spec. to detc.: 1.5 mm
DetectorName: Pilatus 2M
Scan
Title: 'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1)
Measurement date: Oct 18, 2016 / Storage temperature: 10 °C / Cell temperature: 20 °C / Exposure time: 0.045 sec. / Number of frames: 120 / Unit: 1/nm /
MinMax
Q0.095 7.9013
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 545 /
MinMax
Q0.0950367 2.95664
P(R) point1 545
R0 9.21
Result
Type of curve: single_conc /
ExperimentalPorod
MW25.5 kDa26 kDa
Volume-42 nm3

P(R)GuinierGuinier error
Forward scattering, I011350 11423.2 73.9
Radius of gyration, Rg2.753 nm2.7 nm0.05

MinMax
D-9.21
Guinier point1 74

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