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Yorodumi- SASDD75: 'TG'-interacting factor homeodomain in solution (Homeobox protein... -
+Open data
-Basic information
Entry | Database: SASBDB / ID: SASDD75 |
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Sample | 'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1)
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Function / homology | Function and homology information co-SMAD binding / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / cellular response to growth factor stimulus / DNA-binding transcription repressor activity, RNA polymerase II-specific / sequence-specific double-stranded DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / response to xenobiotic stimulus / DNA-binding transcription factor activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding ...co-SMAD binding / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / cellular response to growth factor stimulus / DNA-binding transcription repressor activity, RNA polymerase II-specific / sequence-specific double-stranded DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / response to xenobiotic stimulus / DNA-binding transcription factor activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of gene expression / chromatin / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus Similarity search - Function |
Biological species | Homo sapiens (human) |
Contact author |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Data source
SASBDB page | SASDD75 |
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-Related structure data
Similar structure data |
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-External links
Related items in Molecule of the Month |
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-Models
Model #1826 | Type: dummy / Radius of dummy atoms: 2.25 A / Symmetry: P1 / Chi-square value: 1.123 / P-value: 0.657170 Search similar-shape structures of this assembly by Omokage search (details) |
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Model #1828 | Type: atomic / Symmetry: P1 Comment: Two monomers (B) and (D) have been used as rigid bodies and N- and C-terminal loops were modelled. Chi-square value: 1.721 Search similar-shape structures of this assembly by Omokage search (details) |
Model #1833 | Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.116 / P-value: 0.198541 Search similar-shape structures of this assembly by Omokage search (details) |
Model #1835 | Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.116 / P-value: 0.198541 Search similar-shape structures of this assembly by Omokage search (details) |
Model #1836 | Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 1.116 / P-value: 0.198541 Search similar-shape structures of this assembly by Omokage search (details) |
-Sample
Sample | Name: 'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1) Specimen concentration: 6 mg/ml |
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Buffer | Name: 20 mM Tris, 150 mM NaCl / pH: 7.4 |
Entity #986 | Name: TGIF / Type: protein / Description: Homeobox protein TGIF1 / Formula weight: 10.68 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: Q15583 Sequence: GPDIPLDLSS SAGSGKRRRR GNLPKESVQI LRDWLYEHRY NAYPSEQEKA LLSQQTHLST LQVCNWFINA RRRLLPDMLR KDGKDPNQFT IS |
-Experimental information
Beam | Instrument name: PETRA III P12 / City: Hamburg / 国: Germany / Type of source: X-ray synchrotron / Wavelength: 0.124 Å / Dist. spec. to detc.: 1.5 mm | ||||||||||||||||||||||||||||||
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Detector | Name: Pilatus 2M | ||||||||||||||||||||||||||||||
Scan | Title: 'TG'-interacting factor homeodomain in solution (Homeobox protein TGIF1) Measurement date: Oct 18, 2016 / Storage temperature: 10 °C / Cell temperature: 20 °C / Exposure time: 0.045 sec. / Number of frames: 120 / Unit: 1/nm /
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Distance distribution function P(R) | Sofotware P(R): GNOM 5.0 / Number of points: 545 /
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Result | Type of curve: single_conc /
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