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- PDB-9qwk: Crystal structure of S2c-a5b6 TCR in complex with CD1c -

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Basic information

Entry
Database: PDB / ID: 9qwk
TitleCrystal structure of S2c-a5b6 TCR in complex with CD1c
Components
  • Beta-2-microglobulin,T-cell surface glycoprotein CD1c
  • TCR alpha
  • TCR beta
KeywordsIMMUNE SYSTEM / T cell receptor / TCR / CD1c / lipids
Function / homology
Function and homology information


exogenous lipid antigen binding / antigen processing and presentation, endogenous lipid antigen via MHC class Ib / glycolipid binding / lipopeptide binding / T cell activation involved in immune response / endogenous lipid antigen binding / antigen processing and presentation, exogenous lipid antigen via MHC class Ib / negative regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression ...exogenous lipid antigen binding / antigen processing and presentation, endogenous lipid antigen via MHC class Ib / glycolipid binding / lipopeptide binding / T cell activation involved in immune response / endogenous lipid antigen binding / antigen processing and presentation, exogenous lipid antigen via MHC class Ib / negative regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / transferrin transport / cellular response to iron ion / Endosomal/Vacuolar pathway / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / peptide antigen assembly with MHC class II protein complex / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / cellular response to iron(III) ion / MHC class II protein complex / negative regulation of forebrain neuron differentiation / ER to Golgi transport vesicle membrane / peptide antigen assembly with MHC class I protein complex / regulation of erythrocyte differentiation / regulation of iron ion transport / response to molecule of bacterial origin / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response / MHC class I protein complex / positive regulation of T cell activation / peptide antigen binding / positive regulation of receptor-mediated endocytosis / negative regulation of neurogenesis / positive regulation of T cell mediated cytotoxicity / cellular response to nicotine / multicellular organismal-level iron ion homeostasis / Modulation by Mtb of host immune system / specific granule lumen / phagocytic vesicle membrane / recycling endosome membrane / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / negative regulation of epithelial cell proliferation / MHC class II protein complex binding / late endosome membrane / sensory perception of smell / positive regulation of cellular senescence / tertiary granule lumen / DAP12 signaling / T cell differentiation in thymus / ER-Phagosome pathway / negative regulation of neuron projection development / protein refolding / early endosome membrane / protein homotetramerization / adaptive immune response / amyloid fibril formation / intracellular iron ion homeostasis / learning or memory / endosome membrane / lysosome / immune response / Amyloid fiber formation / endoplasmic reticulum lumen / Golgi membrane / lysosomal membrane / external side of plasma membrane / focal adhesion / intracellular membrane-bounded organelle / Neutrophil degranulation / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / endoplasmic reticulum / Golgi apparatus / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane / cytosol
Similarity search - Function
MHC-I family domain / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type ...MHC-I family domain / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
DECANE / alpha-L-fucopyranose / T-cell surface glycoprotein CD1c / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.27 Å
AuthorsKaruppiah, V. / Rangel, V.L.
Funding support1items
OrganizationGrant numberCountry
Other private
CitationJournal: Front Immunol / Year: 2025
Title: A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c + cells.
Authors: Szoke-Kovacs, R. / Khakoo, S. / Rangel, V.L. / Della Cristina, P. / Pentier, J. / Khanolkar, R. / El-Ajouz, S. / Simmons, R. / Cole, D.K. / Gogolak, P. / Salio, M. / Karuppiah, V.
History
DepositionApr 14, 2025Deposition site: PDBE / Processing site: PDBE
Revision 1.0Aug 20, 2025Provider: repository / Type: Initial release

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
B: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
D: TCR alpha
E: TCR beta
F: TCR beta
G: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
H: TCR alpha
J: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
K: TCR beta
L: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
M: TCR alpha
O: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
P: TCR beta
Q: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
R: TCR alpha
T: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
hetero molecules


Theoretical massNumber of molelcules
Total (without water)603,81237
Polymers598,82716
Non-polymers4,98521
Water1,47782
1
A: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
B: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
D: TCR alpha
E: TCR beta
hetero molecules


Theoretical massNumber of molelcules
Total (without water)150,7889
Polymers149,7074
Non-polymers1,0815
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
F: TCR beta
G: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
H: TCR alpha
J: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
hetero molecules


Theoretical massNumber of molelcules
Total (without water)150,7868
Polymers149,7074
Non-polymers1,0794
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
K: TCR beta
L: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
M: TCR alpha
O: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
hetero molecules


Theoretical massNumber of molelcules
Total (without water)151,39311
Polymers149,7074
Non-polymers1,6867
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
P: TCR beta
Q: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
R: TCR alpha
T: Beta-2-microglobulin,T-cell surface glycoprotein CD1c
hetero molecules


Theoretical massNumber of molelcules
Total (without water)150,8459
Polymers149,7074
Non-polymers1,1385
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)82.233, 83.652, 180.130
Angle α, β, γ (deg.)91.85, 95.99, 115.61
Int Tables number1
Space group name H-MP1

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Components

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Protein , 3 types, 16 molecules ABGJLOQTDHMREFKP

#1: Protein
Beta-2-microglobulin,T-cell surface glycoprotein CD1c


Mass: 49744.504 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P, CD1C / Cell line (production host): HEK293 / Production host: Homo sapiens (human) / References: UniProt: P61769, UniProt: P29017
#2: Protein
TCR alpha


Mass: 22099.484 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)
#3: Protein
TCR beta


Mass: 28118.332 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)

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Sugars , 6 types, 9 molecules

#4: Polysaccharide alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 367.349 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
LFucpa1-6DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-2/a6-b1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(6+1)][a-L-Fucp]{}}LINUCSPDB-CARE
#5: Polysaccharide beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 383.349 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DManpb1-4DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/2,2,1/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-2/a4-b1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-Manp]{}}LINUCSPDB-CARE
#6: Polysaccharide beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1- ...beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 732.682 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DManpb1-4DGlcpNAcb1-4[LFucpa1-6]DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1221m-1a_1-5]/1-1-2-3/a4-b1_a6-d1_b4-c1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{}}[(6+1)][a-L-Fucp]{}}LINUCSPDB-CARE
#7: Polysaccharide 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta- ...2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 570.542 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DGlcpNAcb1-4[LFucpa1-6]DGlcpNAcb1-ROHGlycam Condensed SequenceGMML 1.0
WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1221m-1a_1-5]/1-1-2/a4-b1_a6-c1WURCSPDB2Glycan 1.1.0
[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}[(6+1)][a-L-Fucp]{}}LINUCSPDB-CARE
#10: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0
#11: Sugar ChemComp-FUC / alpha-L-fucopyranose / alpha-L-fucose / 6-deoxy-alpha-L-galactopyranose / L-fucose / fucose


Type: L-saccharide, alpha linking / Mass: 164.156 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C6H12O5
IdentifierTypeProgram
LFucpaCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
a-L-fucopyranoseCOMMON NAMEGMML 1.0
a-L-FucpIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
FucSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 3 types, 94 molecules

#8: Chemical
ChemComp-D10 / DECANE


Mass: 142.282 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C10H22 / Feature type: SUBJECT OF INVESTIGATION
#9: Chemical
ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL


Mass: 62.068 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C2H6O2
#12: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 82 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestY
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop / Details: 0.2 M Sodium thiocyanate and 20 % (w/v) PEG 3350

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Diamond / Beamline: I04 / Wavelength: 0.9537 Å
DetectorType: DECTRIS EIGER2 XE 16M / Detector: PIXEL / Date: Apr 18, 2024
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9537 Å / Relative weight: 1
ReflectionResolution: 2.27→89.24 Å / Num. obs: 194208 / % possible obs: 98.52 % / Redundancy: 3.6 % / CC1/2: 0.963 / Rmerge(I) obs: 0.101 / Rpim(I) all: 0.063 / Rrim(I) all: 0.119 / Net I/σ(I): 14.6
Reflection shellResolution: 2.27→2.31 Å / Redundancy: 3.7 % / Rmerge(I) obs: 1.66 / Mean I/σ(I) obs: 0.8 / Num. unique obs: 9525 / CC1/2: 0.325 / Rpim(I) all: 1.004 / Rrim(I) all: 1.943 / % possible all: 96.77

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Processing

Software
NameVersionClassification
REFMAC5.8.0430refinement
xia2data reduction
xia2data scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.27→89.24 Å / Cor.coef. Fo:Fc: 0.947 / Cor.coef. Fo:Fc free: 0.929 / SU B: 21.668 / SU ML: 0.222 / Cross valid method: THROUGHOUT / ESU R: 0.285 / ESU R Free: 0.214 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
RfactorNum. reflection% reflectionSelection details
Rfree0.25287 2022 1 %RANDOM
Rwork0.22626 ---
obs0.22653 192181 98.52 %-
Solvent computationIon probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK
Displacement parametersBiso mean: 72.912 Å2
Baniso -1Baniso -2Baniso -3
1-3.15 Å21.25 Å2-0.46 Å2
2---1.64 Å21.85 Å2
3----2.35 Å2
Refinement stepCycle: 1 / Resolution: 2.27→89.24 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms25763 0 332 82 26177
Refine LS restraints
Refine-IDTypeDev idealDev ideal targetNumber
X-RAY DIFFRACTIONr_bond_refined_d0.0080.01226923
X-RAY DIFFRACTIONr_bond_other_d0.0010.01624266
X-RAY DIFFRACTIONr_angle_refined_deg1.631.81236524
X-RAY DIFFRACTIONr_angle_other_deg0.5851.75356014
X-RAY DIFFRACTIONr_dihedral_angle_1_deg7.59953220
X-RAY DIFFRACTIONr_dihedral_angle_2_deg11.6225152
X-RAY DIFFRACTIONr_dihedral_angle_3_deg16.935104296
X-RAY DIFFRACTIONr_dihedral_angle_4_deg
X-RAY DIFFRACTIONr_chiral_restr0.1170.23895
X-RAY DIFFRACTIONr_gen_planes_refined0.0070.0232015
X-RAY DIFFRACTIONr_gen_planes_other0.0010.026565
X-RAY DIFFRACTIONr_nbd_refined
X-RAY DIFFRACTIONr_nbd_other
X-RAY DIFFRACTIONr_nbtor_refined
X-RAY DIFFRACTIONr_nbtor_other
X-RAY DIFFRACTIONr_xyhbond_nbd_refined
X-RAY DIFFRACTIONr_xyhbond_nbd_other
X-RAY DIFFRACTIONr_metal_ion_refined
X-RAY DIFFRACTIONr_metal_ion_other
X-RAY DIFFRACTIONr_symmetry_vdw_refined
X-RAY DIFFRACTIONr_symmetry_vdw_other
X-RAY DIFFRACTIONr_symmetry_hbond_refined
X-RAY DIFFRACTIONr_symmetry_hbond_other
X-RAY DIFFRACTIONr_symmetry_metal_ion_refined
X-RAY DIFFRACTIONr_symmetry_metal_ion_other
X-RAY DIFFRACTIONr_mcbond_it3.0883.26112934
X-RAY DIFFRACTIONr_mcbond_other3.0883.26112934
X-RAY DIFFRACTIONr_mcangle_it4.8115.84516136
X-RAY DIFFRACTIONr_mcangle_other4.815.84516137
X-RAY DIFFRACTIONr_scbond_it3.6593.59213989
X-RAY DIFFRACTIONr_scbond_other3.6593.59213990
X-RAY DIFFRACTIONr_scangle_it
X-RAY DIFFRACTIONr_scangle_other5.6466.43920389
X-RAY DIFFRACTIONr_long_range_B_refined7.9435.3528167
X-RAY DIFFRACTIONr_long_range_B_other7.9435.3528168
X-RAY DIFFRACTIONr_rigid_bond_restr
X-RAY DIFFRACTIONr_sphericity_free
X-RAY DIFFRACTIONr_sphericity_bonded
LS refinement shellResolution: 2.274→2.333 Å / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0.348 143 -
Rwork0.337 14032 -
obs--97.08 %
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.9519-0.47280.64192.9265-0.0533.0309-0.064-0.28590.22930.53990.0318-0.4755-0.20450.49450.03220.1164-0.0463-0.09180.3387-0.18260.31832.802124.7715-5.1395
21.59811.10271.49264.99472.45035.6326-0.023-0.61960.29161.2290.0976-0.4331-0.50980.1536-0.07470.6070.0764-0.20070.5545-0.2760.314733.291927.21613.8719
33.2721-0.02031.5170.8861-0.17911.97640.0380.26310.249-0.1716-0.04320.115-0.10070.08090.00520.0683-0.03010.00670.1835-0.08190.1898-11.394321.0379-41.4261
42.09720.27890.51010.4213-0.22670.734-0.0594-0.24770.0896-0.05930.03190.0196-0.1204-0.02080.02750.0638-0.029-0.01760.2002-0.15530.2174-20.565416.7821-25.3554
50.6953-0.2650.82050.871-0.773.520.0389-0.0645-0.2499-0.01970.17850.19840.5704-0.2281-0.21740.49290.0199-0.07780.391-0.06560.322120.728947.961948.2237
60.4029-0.21840.28271.2540.51323.6227-0.098-0.0346-0.03280.06790.0965-0.01160.0257-0.00920.00140.25380.022-0.04320.3073-0.07190.245814.093963.0393-7.5944
71.6043-0.41160.95871.5582-0.88183.7681-0.02010.0014-0.04560.1058-0.0713-0.18340.14780.34680.09140.31590.1003-0.07890.3476-0.15460.262537.43356.649345.0684
81.8517-1.1093-0.32993.08572.14364.3725-0.23640.0196-0.51810.10880.10070.5070.5155-0.40930.13560.2821-0.0752-0.00160.2981-0.04170.3646-0.347453.4791-15.3861
91.3013-0.40560.84261.0459-1.14461.81520.0022-0.1194-0.0378-0.0266-0.0389-0.04710.0751-0.10690.03680.0557-0.0437-0.00620.2118-0.15860.206636.925857.0635-38.9912
102.9285-0.25470.36651.59050.34092.8176-0.0050.78840.1566-0.49710.03440.3666-0.1508-0.1606-0.02940.5056-0.0035-0.20220.5027-0.07860.221820.1972.6544-92.0126
111.8752-0.16551.11551.6448-0.70673.83760.01650.0515-0.02880.0093-0.1551-0.35760.07570.3490.13860.0158-0.03180.01210.2301-0.12610.259351.387268.5891-43.6572
123.74170.78760.67763.72761.65263.7207-0.27920.5521-0.4842-0.29050.00690.67070.3571-0.22050.27240.6015-0.0046-0.24190.5506-0.19580.44216.614160.6993-97.7695
132.7357-0.57211.27911.4293-0.39632.50440.0991-0.0980.0218-0.1118-0.04170.43770.0144-0.4083-0.05750.38090.0687-0.09260.3547-0.17970.4174-12.61726.1031-119.8996
141.8178-0.02311.16642.2535-0.28153.2838-0.0464-0.0338-0.130.4454-0.0751-0.5135-0.29380.66080.12150.5448-0.0148-0.21880.5072-0.12970.416939.29526.9049-93.6641
153.23410.01251.21131.39110.02862.82170.05050.42160.4023-0.3272-0.11090.2666-0.2245-0.0610.06040.50480.0707-0.16020.355-0.13150.2887-1.339627.0328-135.228
162.00560.64170.82932.24121.44375.7044-0.0087-0.37440.02950.5208-0.07050.0387-0.63840.02510.07930.87480.0409-0.2060.4812-0.08020.330236.631531.0501-75.7317
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1A7 - 289
2X-RAY DIFFRACTION2B1 - 104
3X-RAY DIFFRACTION3D2 - 200
4X-RAY DIFFRACTION4E1 - 245
5X-RAY DIFFRACTION5F120 - 362
6X-RAY DIFFRACTION6G8 - 286
7X-RAY DIFFRACTION7H3 - 201
8X-RAY DIFFRACTION8J1 - 104
9X-RAY DIFFRACTION9K119 - 362
10X-RAY DIFFRACTION10L8 - 285
11X-RAY DIFFRACTION11M3 - 201
12X-RAY DIFFRACTION12O0 - 104
13X-RAY DIFFRACTION13P120 - 362
14X-RAY DIFFRACTION14Q8 - 284
15X-RAY DIFFRACTION15R3 - 201
16X-RAY DIFFRACTION16T0 - 104

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