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TitleA CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c + cells.
Journal, issue, pagesFront Immunol, Vol. 16, Page 1614610-1614610, Year 2025
Publish dateApr 14, 2025 (structure data deposition date)
AuthorsSzoke-Kovacs, R. / Khakoo, S. / Rangel, V.L. / Della Cristina, P. / Pentier, J. / Khanolkar, R. / El-Ajouz, S. / Simmons, R. / Cole, D.K. / Gogolak, P. ...Szoke-Kovacs, R. / Khakoo, S. / Rangel, V.L. / Della Cristina, P. / Pentier, J. / Khanolkar, R. / El-Ajouz, S. / Simmons, R. / Cole, D.K. / Gogolak, P. / Salio, M. / Karuppiah, V.
External linksFront Immunol / PubMed:40777002
MethodsX-ray diffraction
Resolution2.04 - 2.27 Å
Structure data

PDB-9qwj:
Crystal structure of S2c TCR in complex with CD1c
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

PDB-9qwk:
Crystal structure of S2c-a5b6 TCR in complex with CD1c
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-BMA:
beta-D-mannopyranose

ChemComp-D12:
DODECANE

ChemComp-CA:
Unknown entry

ChemComp-D10:
DECANE

ChemComp-HOH:
WATER

ChemComp-FUC:
alpha-L-fucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / T cell receptor / TCR / CD1c / lipids

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