PDB-9l88: Structure of human TREX1-DNA complex with K66R disease-associated...

ID or keywords:

Entry

Database: PDB / ID: 9l88

Title

Structure of human TREX1-DNA complex with K66R disease-associated mutation

Components

DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')
Three-prime repair exonuclease 1

Keywords

IMMUNE SYSTEM/DNA / nuclease / DNase / innate immunity / autoimmunity / cancer / IMMUNE SYSTEM-DNA complex

Function / homology

Function and homology information

Regulation by TREX1 / adenyl deoxyribonucleotide binding / MutSalpha complex binding / oligosaccharyltransferase complex / exodeoxyribonuclease III / double-stranded DNA 3'-5' DNA exonuclease activity / MutLalpha complex binding / 3'-5'-DNA exonuclease activity / IRF3-mediated induction of type I IFN / DNA catabolic process ...
Similarity search - Function

Biological species

Homo sapiens (human)
synthetic construct (others)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.62 Å

Authors

Zhu, J. / Wang, L. / Lin, C. / Zhou, W.

Funding support

China, 1items

Citation

Journal: Immunity / Year: 2026
Title: Distinct recognition pattern for double-stranded DNA allows TREX1 to maintain immune homeostasis
Authors: Zhu, J. / Wang, L. / Lin, C. / Zhou, W.

History

Deposition	Dec 27, 2024	Deposition site: PDBJ / Processing site: PDBC
Revision 1.0	Apr 29, 2026	Provider: repository / Type: Initial release

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	9l88.cif.gz	407.4 KB	Display	PDBx/mmCIF format
PDB format	pdb9l88.ent.gz	329.5 KB	Display	PDB format
PDBx/mmJSON format	9l88.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/l8/9l88 ftp://data.pdbj.org/pub/pdb/validation_reports/l8/9l88	HTTPS FTP

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Related structure data

Related structure data	9l85C 9l86C 9l87C 9l89C 9l8aC 9l8bC 9l8cC 9l8dC 7tqqS S: Starting model for refinement C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#67 - Jul 2005 TATA-Binding Protein similarity (1) #168 - Dec 2013 DNA Helicase similarity (1) #255 - Mar 2021 Cisplatin and DNA similarity (1) #91 - Jul 2007 Thymine Dimers similarity (1) #122 - Feb 2010 Enhanceosome similarity (2) #172 - Apr 2014 RecA and Rad51 similarity (1) #181 - Jan 2015 Cascade and CRISPR similarity (1) #253 - Jan 2021 Expressome similarity (1) #112 - Apr 2009 Oct and Sox Transcription Factors similarity (1) #135 - Mar 2011 Integrase similarity (1) #150 - Jun 2012 Sliding Clamps similarity (1) #180 - Dec 2014 TAL Effectors similarity (1) #227 - Nov 2018 Telomerase similarity (1) #48 - Dec 2003 Catabolite Activator Protein similarity (1) #84 - Dec 2006 Transposase similarity (1) #139 - Jul 2011 DNA Methyltransferase similarity (1) #155 - Nov 2012 Vitamin D Receptor similarity (1) #3 - Mar 2000 DNA Polymerase similarity (1) #40 - Apr 2003 RNA Polymerase similarity (1) #73 - Jan 2006 Topoisomerase similarity (1) #87 - Mar 2007 Zinc Fingers similarity (1) #55 - Jul 2004 DNA Ligase similarity (2) #119 - Nov 2009 Designed DNA Crystal similarity (1) #125 - May 2010 Parvoviruses similarity (1) #131 - Nov 2010 Inteins similarity (1) #160 - Apr 2013 Actinomycin similarity (1) #190 - Oct 2015 Two-component Systems similarity (1) #23 - Nov 2001 DNA similarity (1) #240 - Dec 2019 Hypoxia-Inducible Factors similarity (1) #257 - May 2021 Fetal Hemoglobin similarity (1) #258 - Jun 2021 Glucocorticoid Receptor and Dexamethasone similarity (1) #31 - Jul 2002 p53 Tumor Suppressor similarity (1) #33 - Sep 2002 HIV Reverse Transcriptase similarity (1) #39 - Mar 2003 lac Repressor similarity (1) #45 - Sep 2003 Estrogen Receptor similarity (1) #7 - Jul 2000 Nucleosome similarity (1) #8 - Aug 2000 Restriction Enzymes similarity (1) #92 - Aug 2007 Anabolic Steroids similarity (1) #234 - Jun 2019 MDM2 and Cancer similarity (1) #241 - Jan 2020 Twenty Years of Molecules similarity (1) #50 - Feb 2004 Glycolytic Enzymes similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

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Deposited unit

A: Three-prime repair exonuclease 1

B: Three-prime repair exonuclease 1

C: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

D: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

E: Three-prime repair exonuclease 1

F: Three-prime repair exonuclease 1

G: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

H: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

hetero molecules

131 kDa, 8 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Three-prime repair exonuclease 1

B: Three-prime repair exonuclease 1

C: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

D: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

hetero molecules

defined by author&software
Evidence: gel filtration
65.4 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

E: Three-prime repair exonuclease 1

F: Three-prime repair exonuclease 1

G: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

H: DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')

hetero molecules

defined by author&software
65.4 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	44.257, 92.712, 160.551
Angle α, β, γ (deg.)	90.00, 90.89, 90.00
Int Tables number	4
Space group name H-M	P12₁1

#1: Protein	Three-prime repair exonuclease 1 / 3'-5' exonuclease TREX1 / Deoxyribonuclease III / DNase III Mass: 26008.924 Da / Num. of mol.: 4 / Mutation: K66R Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: TREX1 / Production host: Escherichia coli (E. coli) / References: UniProt: Q9NSU2, exodeoxyribonuclease III
#2: DNA chain	DNA (5'-D(PGPTPTPGPGPCPCPCPTPCPTPTPTPAPGPGPGPCPCPAPTPC)-3') Mass: 6710.313 Da / Num. of mol.: 4 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)
#3: Chemical	ChemComp-LI / LITHIUM ION Mass: 6.941 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Li
#4: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 223 / Source method: isolated from a natural source / Formula: H₂O
Has ligand of interest	N
Has protein modification	N

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.52 Å³/Da / Density % sol: 51.12 %
Crystal grow	Temperature: 289 K / Method: vapor diffusion, hanging drop Details: 0.05 M Li2SO4, 22.5% PEG-3350, 0.1M Bis-Tris pH 6.5

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Data collection

Diffraction	Mean temperature: 80 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: SSRF / Beamline: BL18U1 / Wavelength: 0.9792 Å
Detector	Type: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Apr 2, 2023
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.9792 Å / Relative weight: 1
Reflection	Resolution: 2.62→32.22 Å / Num. obs: 38765 / % possible obs: 99.34 % / Redundancy: 8.3 % / B_iso Wilson estimate: 33.61 Å² / CC_1/2: 0.976 / R_pim(I) all: 0.07 / Net I/σ(I): 11.3
Reflection shell	Resolution: 2.62→2.69 Å / Redundancy: 7.5 % / Mean I/σ(I) obs: 2.1 / Num. unique obs: 3673 / CC_1/2: 0.717 / R_pim(I) all: 0.322 / % possible all: 93.33

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Processing

Software

Name	Version	Classification
PHENIX	1.21.1_5127	refinement
HKL-2000		data scaling
HKL-2000		data reduction
PHENIX		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 7TQQ

7tqq

Resolution: 2.62→32.22 Å / SU ML: 0.32 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 22.4 / Stereochemistry target values: ML

	R_factor	Num. reflection	% reflection
R_free	0.2318	2000	5.16 %
R_work	0.1946	-	-
obs	0.1965	38765	99.34 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 42.99 Å²

Refinement step

Cycle: LAST / Resolution: 2.62→32.22 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	6510	1223	2	223	7958

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.004	8046
X-RAY DIFFRACTION	f_angle_d	0.696	11209
X-RAY DIFFRACTION	f_dihedral_angle_d	20.432	3029
X-RAY DIFFRACTION	f_chiral_restr	0.042	1284
X-RAY DIFFRACTION	f_plane_restr	0.005	1243

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.62-2.69	0.255	135	0.2297	2427	X-RAY DIFFRACTION	93
2.69-2.76	0.2639	140	0.2305	2656	X-RAY DIFFRACTION	99
2.76-2.84	0.2858	147	0.2431	2582	X-RAY DIFFRACTION	100
2.84-2.93	0.2987	139	0.2338	2651	X-RAY DIFFRACTION	99
2.93-3.04	0.3042	141	0.2285	2606	X-RAY DIFFRACTION	100
3.04-3.16	0.2559	144	0.2082	2640	X-RAY DIFFRACTION	100
3.16-3.3	0.2252	143	0.2089	2614	X-RAY DIFFRACTION	100
3.3-3.48	0.2559	142	0.2095	2612	X-RAY DIFFRACTION	100
3.48-3.7	0.2561	148	0.1944	2682	X-RAY DIFFRACTION	100
3.7-3.98	0.2478	136	0.1773	2628	X-RAY DIFFRACTION	100
3.98-4.38	0.19	147	0.163	2648	X-RAY DIFFRACTION	100
4.38-5.01	0.181	150	0.1557	2634	X-RAY DIFFRACTION	100
5.01-6.3	0.1866	152	0.1851	2669	X-RAY DIFFRACTION	100
6.31-32.22	0.2176	136	0.1926	2716	X-RAY DIFFRACTION	100

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.21	-0.1738	0.5269	0.262	0.0281	0.8384	-0.0367	-0.1446	0.0952	0.7045	-0.0227	0.1252	-0.2476	-0.0532	-0.0014	0.3946	-0.0274	0.0478	0.291	-0.0264	0.3805	4.4556	27.9252	-55.3036
2	0.067	0.1204	-0.4818	2.1269	0.3761	1.1812	-0.0309	-0.1696	-0.0373	0.2828	-0.0199	-0.2019	-0.0016	0.2774	0.1202	0.2522	-0.022	-0.0372	0.3312	0.0176	0.3193	9.6069	20.121	-56.6586
3	0.908	-0.0784	-0.4466	1.5389	-0.4097	1.2675	0.0516	-0.4347	0.025	0.7035	0.0256	0.1495	-0.0419	-0.1327	0.046	0.5296	-0.0004	0.013	0.3491	-0.0594	0.1957	0.6696	26.8177	-47.9617
4	0.3891	0.0312	-0.1215	0.8933	-0.9855	0.6841	-0.2221	-0.1247	-0.0242	-0.3459	0.289	-0.1045	0.0857	0.1858	0.3238	0.1786	-0.0448	0.0374	0.2757	-0.0146	0.3862	1.6991	21.625	-81.6996
5	0.1695	-0.5274	-0.0957	0.3829	-0.4401	0.2621	0.0475	-0.1738	0.0771	-0.1989	-0.1827	0.2762	-0.0131	0.1472	-0.2311	0.2132	-0.0568	-0.0008	0.1943	0.0322	0.3282	0.2333	29.0325	-78.924
6	1.4405	-0.5668	0.6791	0.7494	0.2795	0.9362	-0.3562	-0.4943	-0.463	-0.3152	0.1311	0.2769	0.1767	-0.3028	-0.2743	0.288	-0.142	0.0599	0.2726	-0.0334	0.2754	-7.0017	17.4085	-69.8544
7	0.2771	0.5286	0.3576	0.8091	-0.344	0.7953	-0.1246	0.0298	-0.0345	0.4114	-0.0478	-0.1328	-0.0871	0.1524	-0.0005	0.2575	-0.0151	-0	0.27	-0.0025	0.3179	6.2117	37.8751	-72.3547
8	0.3414	0.1072	-0.2002	0.2738	0.1882	0.5715	-0.0039	0.3325	-0.068	-0.1495	-0.2707	0.3724	0.1945	0.2358	-0.1651	0.2489	0.0426	0.033	0.2545	0.0456	0.382	1.4471	24.4491	-83.8447
9	0.4249	-0.0855	0.8879	0.2506	-0.1065	1.7034	-0.4659	0.2169	-0.3466	-0.2318	0.2295	-0.4268	-0.297	0.415	-0.2561	0.1876	0.0246	0.1246	0.2389	-0.0218	0.3177	10.5663	31.863	-84.8064
10	0.0131	0.1439	-0.1029	0.911	-0.8159	0.7647	0.3901	0.7904	-0.6915	-0.8603	-0.338	-0.381	-0.2723	-0.048	-0.2782	0.4173	0.0258	0.0079	0.2749	-0.1121	0.363	-8.7252	22.6091	-89.3183
11	0.1361	0.2487	0.2733	0.7986	-0.0058	0.7569	-0.0776	-0.1188	0.1767	0.1645	0.0279	0.4958	-0.1497	-0.3114	-0.0184	0.1909	-0.0086	0.0482	0.2321	0.0044	0.3492	-13.6938	27.3968	-77.4412
12	0.8831	-0.3738	0.2618	0.2096	-0.094	0.2736	-0.0898	0.3534	-1.0004	-0.5634	-0.266	0.5952	0.3421	-0.6759	0.0713	0.3946	-0.0564	-0.1076	0.2926	-0.1126	0.4001	-8.4048	14.425	-86.0609
13	0.8757	-0.7853	-0.0146	0.6804	-0.0118	0.0493	-0.0347	-0.2162	0.6632	-1.059	0.1805	-0.905	-0.076	0.2401	-0.0177	0.4486	-0.008	0.1181	0.2695	-0.0291	0.3965	6.3522	30.9932	-91.1194
14	1.1441	-0.7309	-0.0503	0.4577	0.0456	0.0042	-0.3779	-0.0338	-1.385	0.4489	0.2158	0.7022	1.0983	-0.3333	-0.0533	1.3331	0.0781	-0.0826	1.1105	-0.0017	0.6796	6.0116	7.5385	-40.2285
15	0.144	0.1867	-0.0642	0.1387	-0.0362	0.0901	0.8749	-1.3469	-0.667	0.2407	0.4072	-0.8243	-0.7374	0.8248	0.0004	1.3509	-0.1104	-0.0714	1.506	0.063	0.8871	5.8908	14.6287	-27.1833
16	1.2921	0.0928	-0.9432	0.0553	-0.1215	0.7639	0.9723	0.1623	0.4287	0.5202	0.6031	0.1372	0.7491	-0.4013	0.2767	0.6922	-0.0618	-0.0373	0.3744	-0.0562	0.2458	0.7642	12.2479	-39.2072
17	0.9636	-0.7457	0.3607	3.0332	-1.4455	1.1547	-0.0686	-0.1528	-0.5025	-1.604	0.4881	1.1615	0.6009	-0.8059	1.2459	0.5042	-0.1589	-0.3138	0.294	-0.1373	0.5103	-12.3419	39.4203	-93.09
18	-0.1499	0.5374	-0.3374	0.3337	-0.2525	0.9981	-0.2242	0.0958	-0.1331	-0.0733	0.1391	-0.1718	0.0345	-0.0414	-0.0011	0.2586	0.0282	-0.018	0.3294	-0.0353	0.3394	-15.0178	-14.3025	-25.2061
19	0.2321	-0.229	-0.0718	0.2204	0.2514	0.6396	-0.0863	-0.2363	0.5067	-0.2448	0.0458	-0.2783	-0.177	-0.0004	-0.0097	0.2301	-0.0521	-0.0151	0.2758	0.1093	0.3867	-4.9429	0.5128	-16.8793
20	0.2416	0.3949	-0.0706	0.7278	0.0408	0.9194	-0.0366	0.0051	-0.0952	0.3229	-0.1166	0.0661	0.0684	0.0603	-0.0194	0.2204	-0.0216	0.0371	0.216	0.0123	0.2467	-19.9044	-23.3858	-17.4217
21	0.2211	0.1278	0.0695	1.1313	1.14	1.6865	-0.0615	0.4501	0.0604	-0.9962	-0.1824	0.0697	-0.9003	-0.3317	-0.1783	0.2442	-0.078	0.0824	0.4344	0.0687	0.198	-15.632	-11.3825	-29.4446
22	0.8381	-0.301	0.0593	0.4969	-0.4888	0.4818	0.0802	0.4114	0.4885	-0.5295	0.0259	0.1161	0.122	-0.1328	0.0188	0.3235	-0.0554	-0.0238	0.4089	-0.0341	0.1844	-17.4756	-15.2761	-32.0168
23	-0.0088	0.0171	0.0095	0.2805	0.0057	-0.0063	-0.2404	0.1839	-0.3784	-0.4256	0.4761	-0.7482	0.1307	0.1651	-0.0001	0.3623	-0.0703	0.0779	0.3468	-0.0224	0.3728	3.6803	-13.4312	-29.5417
24	0.2999	-0.0902	-0.0307	0.5242	-0.298	0.5696	-0.0835	0.1788	-0.2928	-0.1472	-0.0503	-0.7716	0.3353	0.4129	0.002	0.302	0.0267	0.0087	0.4331	0.028	0.3012	-3.6439	-14.7828	-19.2825
25	0.2531	-0.0746	-0.0907	0.1066	0.1611	0.1335	-0.0447	0.4801	0.134	-0.4882	-0.0933	-0.1537	-0.0254	0.4492	0.0363	0.4156	-0.0612	0.0149	0.3963	0.1187	0.3536	-6.1221	-1.1358	-31.5557
26	0.5672	-0.1094	-0.3029	0.0283	0.0815	0.1464	0.1076	0.1427	0.0055	-0.7597	0.1903	0.4725	0.769	-0.5313	-0.0143	0.5385	-0.0628	-0.171	0.4182	-0.0436	0.2	-20.3066	-18.1688	-36.6932
27	0.0623	-0.0721	0.0062	0.2978	-0.1058	0.7413	0.072	0.1315	0.0853	0.0989	-0.0844	-0.0059	0.0869	-0.084	-0.0092	0.2545	-0.0015	-0.0112	0.2504	0.0192	0.3701	-21.661	-12.0108	0.0481
28	0.1135	0.0856	0.1199	0.4061	-0.3189	1.1444	-0.2397	-0.8728	-0.0554	0.076	0.4986	0.0716	0.4794	-0.3787	0.0373	0.3743	0.1427	-0.0987	0.3943	0.0035	0.3269	-7.2122	-24.6399	-3.1971
29	-0.05	-0.1613	-0.2628	1.3446	0.3134	0.3338	0.022	0.1784	0.0734	-0.1305	-0.084	-0.0273	-0.1507	-0.0616	-0.1748	0.1303	0.0191	-0.0173	0.2054	0.0287	0.2353	-22.7632	-5.099	-6.3569
30	0.1705	-0.0404	0.2991	0.0902	-0.1539	0.0784	-0.2867	-0.2547	-0.4029	0.4081	0.0622	-0.0131	-0.2737	-0.4062	0.0011	0.2909	-0.0034	0.0264	0.3269	0.0571	0.3815	-32.6044	-6.6604	-0.5359
31	0.7237	0.6315	-0.2114	1.3208	0.0258	0.5698	0.3959	-0.0097	0.0276	0.8513	-0.168	0.5989	0.5752	0.4854	0.2538	0.8587	-0.015	-0.1193	0.2423	-0.0455	0.2146	-18.2553	-15.6059	11.7916
32	0.6133	0.0497	-0.1045	0.0102	0.2041	0.8434	-0.6904	-0.6502	-0.3971	1.5294	0.302	-0.8548	0.7259	0.6899	-0.2124	-0.4364	0.4631	-1.0542	0.2558	0.2278	-0.0802	-7.0194	-12.4372	12.178
33	0.0379	0.058	0.0289	0.0829	0.0508	0.0512	-0.229	-0.0159	-0.0333	0.6949	-0.5581	-0.1441	-0.5152	0.6175	0.0003	0.3557	0.0601	0.011	0.7396	0.0794	0.6125	-4.9732	-6.5949	0.0125
34	0.8558	-0.4965	0.5595	0.3494	-0.0661	1.7013	0.1482	-0.3308	-0.4825	0.9219	-0.0451	-0.2598	0.13	0.4119	0.2874	0.4176	0.011	-0.042	0.2497	0.0483	0.3178	-14.3472	-19.3983	5.7706
35	0.058	-0.0493	-0.0346	0.0332	0.0503	0.0293	0.1354	0.362	-0.1336	0.7999	-0.0602	0.7592	-0.102	-0.0475	-0.0125	0.3284	-0.0272	0.0573	0.367	0.0413	0.4641	-32.0676	-7.6221	6.8268
36	1.3323	1.1479	2.9037	2.7607	1.9102	7.5016	-0.3422	1.7497	-0.3657	-0.1037	1.3942	-1.1442	1.8973	0.8875	1.3012	0.4847	-0.101	0.2569	1.0141	0.0761	0.5025	-2.6835	-27.8444	-38.1465
37	0.8876	-0.14	0.2455	0.3563	0.3976	1.0664	-0.0249	-0.4787	-0.1894	1.5616	0.4498	-0.4058	0.4097	0.7003	0.6739	0.9745	0.1354	-0.0554	0.4059	0.0813	0.2309	-18.8574	0.4826	17.6703

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 7 through 64 )
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 65 through 165 )
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 166 through 234 )
4	X-RAY DIFFRACTION	4	chain 'B' and (resid 7 through 21 )
5	X-RAY DIFFRACTION	5	chain 'B' and (resid 22 through 45 )
6	X-RAY DIFFRACTION	6	chain 'B' and (resid 46 through 70 )
7	X-RAY DIFFRACTION	7	chain 'B' and (resid 71 through 114 )
8	X-RAY DIFFRACTION	8	chain 'B' and (resid 115 through 129 )
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 130 through 150 )
10	X-RAY DIFFRACTION	10	chain 'B' and (resid 151 through 164 )
11	X-RAY DIFFRACTION	11	chain 'B' and (resid 165 through 208 )
12	X-RAY DIFFRACTION	12	chain 'B' and (resid 209 through 222 )
13	X-RAY DIFFRACTION	13	chain 'B' and (resid 223 through 234 )
14	X-RAY DIFFRACTION	14	chain 'C' and (resid 1 through 5 )
15	X-RAY DIFFRACTION	15	chain 'C' and (resid 6 through 16 )
16	X-RAY DIFFRACTION	16	chain 'C' and (resid 17 through 22 )
17	X-RAY DIFFRACTION	17	chain 'D' and (resid 1 through 22 )
18	X-RAY DIFFRACTION	18	chain 'E' and (resid 8 through 44 )
19	X-RAY DIFFRACTION	19	chain 'E' and (resid 45 through 64 )
20	X-RAY DIFFRACTION	20	chain 'E' and (resid 65 through 114 )
21	X-RAY DIFFRACTION	21	chain 'E' and (resid 115 through 129 )
22	X-RAY DIFFRACTION	22	chain 'E' and (resid 130 through 163 )
23	X-RAY DIFFRACTION	23	chain 'E' and (resid 164 through 187 )
24	X-RAY DIFFRACTION	24	chain 'E' and (resid 188 through 208 )
25	X-RAY DIFFRACTION	25	chain 'E' and (resid 209 through 222 )
26	X-RAY DIFFRACTION	26	chain 'E' and (resid 223 through 234 )
27	X-RAY DIFFRACTION	27	chain 'F' and (resid 7 through 45 )
28	X-RAY DIFFRACTION	28	chain 'F' and (resid 46 through 64 )
29	X-RAY DIFFRACTION	29	chain 'F' and (resid 65 through 129 )
30	X-RAY DIFFRACTION	30	chain 'F' and (resid 130 through 150 )
31	X-RAY DIFFRACTION	31	chain 'F' and (resid 151 through 163 )
32	X-RAY DIFFRACTION	32	chain 'F' and (resid 164 through 187 )
33	X-RAY DIFFRACTION	33	chain 'F' and (resid 188 through 196 )
34	X-RAY DIFFRACTION	34	chain 'F' and (resid 197 through 222 )
35	X-RAY DIFFRACTION	35	chain 'F' and (resid 223 through 234 )
36	X-RAY DIFFRACTION	36	chain 'G' and (resid 1 through 22 )
37	X-RAY DIFFRACTION	37	chain 'H' and (resid 1 through 22 )

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