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Yorodumi- PDB-8xfd: Crystal structure of pyruvate kinase tetramer in complex with all... -
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-Basic information
Entry | Database: PDB / ID: 8xfd | ||||||
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Title | Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348) | ||||||
Components | Isoform L-type of Pyruvate kinase PKLR | ||||||
Keywords | TRANSFERASE / pyruvate kinase / allosteric activator / Mitapivat / AG-348 | ||||||
Function / homology | Function and homology information pyruvate kinase complex / pyruvate biosynthetic process / SARS-CoV-1-host interactions / ChREBP activates metabolic gene expression / pyruvate kinase / pyruvate kinase activity / Pyruvate metabolism / monosaccharide binding / response to metal ion / Glycolysis ...pyruvate kinase complex / pyruvate biosynthetic process / SARS-CoV-1-host interactions / ChREBP activates metabolic gene expression / pyruvate kinase / pyruvate kinase activity / Pyruvate metabolism / monosaccharide binding / response to metal ion / Glycolysis / response to ATP / Regulation of gene expression in beta cells / potassium ion binding / response to glucose / response to cAMP / cellular response to epinephrine stimulus / response to nutrient / glycolytic process / cellular response to insulin stimulus / kinase activity / response to hypoxia / magnesium ion binding / extracellular exosome / ATP binding / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.1 Å | ||||||
Authors | Sun, R. / Achour, A. | ||||||
Funding support | 1items
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Citation | Journal: Crystals / Year: 2024 Title: High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348 Authors: Han, X. / Sandalova, T. / Zhang, C. / Mardinoglu, A. / Achour, A. / Sun, R. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 8xfd.cif.gz | 954.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb8xfd.ent.gz | 659.9 KB | Display | PDB format |
PDBx/mmJSON format | 8xfd.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/xf/8xfd ftp://data.pdbj.org/pub/pdb/validation_reports/xf/8xfd | HTTPS FTP |
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-Related structure data
Similar structure data | Similarity search - Function & homologyF&H Search |
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Experimental dataset #1 | Data reference: 10.15151/ESRF-ES-998474512 / Data set type: diffraction image data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: ens_1
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