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TitleHigh Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348
Journal, issue, pagesCrystals, Year 2024
Publish dateDec 13, 2023 (structure data deposition date)
AuthorsHan, X. / Sandalova, T. / Zhang, C. / Mardinoglu, A. / Achour, A. / Sun, R.
External linksCrystals / Search PubMed
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-8xfd:
Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose


ChemComp, No image

ChemComp-WV2:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / pyruvate kinase / allosteric activator / Mitapivat / AG-348

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