Entry | Database: PDB / ID: 8ven |
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Title | Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with cefoperazone |
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Components | Probable peptidoglycan D,D-transpeptidase PenA |
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Keywords | HYDROLASE / penicillin-binding protein / transpeptidase / complex |
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Function / homology | Function and homology information
peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / FtsZ-dependent cytokinesis / serine-type D-Ala-D-Ala carboxypeptidase activity / division septum assembly / penicillin binding / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / response to antibiotic ...peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / FtsZ-dependent cytokinesis / serine-type D-Ala-D-Ala carboxypeptidase activity / division septum assembly / penicillin binding / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / response to antibiotic / proteolysis / plasma membraneSimilarity search - Function Peptidoglycan D,D-transpeptidase FtsI / Penicillin-binding protein, dimerisation domain / Penicillin-binding Protein dimerisation domain / Penicillin-binding protein, dimerisation domain superfamily / Penicillin-binding protein, transpeptidase / Penicillin binding protein transpeptidase domain / Beta-lactamase/transpeptidase-likeSimilarity search - Domain/homology |
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Biological species | Neisseria gonorrhoeae (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution: 1.8 Å |
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Authors | Stratton, C. / Bala, S. / Davies, C. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI164794 | United States |
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Citation | Journal: Acs Infect Dis. / Year: 2024 Title: Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041. Authors: Turner, J.M. / Stratton, C.M. / Bala, S. / Cardenas Alvarez, M. / Nicholas, R.A. / Davies, C. |
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History | Deposition | Dec 20, 2023 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Mar 20, 2024 | Provider: repository / Type: Initial release |
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Revision 1.1 | Apr 24, 2024 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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