登録情報 データベース : PDB / ID : 8tt8 構造の表示 ダウンロードとリンクタイトル Joint Xray/Neutron structure of Macrophage Migration Inhibitory Factor (MIF) Bound to 4-hydroxyphenylpyruvate at room temperature 要素Macrophage migration inhibitory factor 詳細 キーワード CYTOKINE / MACROPHAGE MIGRATION INHIBITORY FACTOR機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of prostaglandin secretion involved in immune response / positive regulation of myeloid leukocyte cytokine production involved in immune response / dopachrome isomerase activity / phenylpyruvate tautomerase / L-dopachrome isomerase / phenylpyruvate tautomerase activity / positive regulation of arachidonate secretion / cytokine receptor binding / negative regulation of myeloid cell apoptotic process / negative regulation of macrophage chemotaxis ... positive regulation of prostaglandin secretion involved in immune response / positive regulation of myeloid leukocyte cytokine production involved in immune response / dopachrome isomerase activity / phenylpyruvate tautomerase / L-dopachrome isomerase / phenylpyruvate tautomerase activity / positive regulation of arachidonate secretion / cytokine receptor binding / negative regulation of myeloid cell apoptotic process / negative regulation of macrophage chemotaxis / negative regulation of mature B cell apoptotic process / carboxylic acid metabolic process / positive regulation of lipopolysaccharide-mediated signaling pathway / positive regulation of chemokine (C-X-C motif) ligand 2 production / prostaglandin biosynthetic process / negative regulation of protein metabolic process / regulation of macrophage activation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / chemoattractant activity / protein homotrimerization / negative regulation of DNA damage response, signal transduction by p53 class mediator / positive regulation of cAMP/PKA signal transduction / negative regulation of cellular senescence / positive regulation of phosphorylation / positive regulation of B cell proliferation / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / negative regulation of cell migration / positive regulation of cytokine production / cytokine activity / Cell surface interactions at the vascular wall / DNA damage response, signal transduction by p53 class mediator / positive regulation of fibroblast proliferation / positive regulation of tumor necrosis factor production / cellular senescence / protease binding / secretory granule lumen / vesicle / ficolin-1-rich granule lumen / cell surface receptor signaling pathway / positive regulation of ERK1 and ERK2 cascade / inflammatory response / negative regulation of gene expression / innate immune response / positive regulation of cell population proliferation / Neutrophil degranulation / negative regulation of apoptotic process / cell surface / extracellular space / extracellular exosome / extracellular region / nucleoplasm / identical protein binding / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Macrophage migration inhibitory factor, conserved site / Macrophage migration inhibitory factor family signature. / Macrophage migration inhibitory factor / Macrophage migration inhibitory factor (MIF) / Tautomerase/MIF superfamily 類似検索 - ドメイン・相同性 Chem-EN1 / 3-(4-HYDROXY-PHENYL)PYRUVIC ACID / ISOPROPYL ALCOHOL / Macrophage migration inhibitory factor 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 中性子回折 / NUCLEAR REACTOR / フーリエ合成 / 解像度 : 1.75 Å 詳細データ登録者 Schroder, G.C. / Meilleur, F. / Crichlow, G.V. / Lolis, E.J. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 Department of Energy (DOE, United States) 米国
引用ジャーナル : To Be Published タイトル : Joint Xray/Neutron structure of Macrophage Migration Inhibitory Factor (MIF) Bound to 4-hydroxyphenylpyruvate at room temperature著者 : Schroder, G.C. / Crichlow, G.V. / Zambrzycka, E. / Pantouris, G. / Nix, J. / Chayen, N. / Meilleur, F. / Lolis, E.J. 履歴 登録 2023年8月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2025年8月27日 Provider : repository / タイプ : Initial release