+Open data
-Basic information
Entry | Database: PDB / ID: 8trv | |||||||||
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Title | Structure of the EphA2 LBDCRD bound to FabS1C_C1 | |||||||||
Components |
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Keywords | SIGNALING PROTEIN/IMMUNE SYSTEM / Cell signalling / antibody / agonist / high affinity / clustering / activation / SIGNALING PROTEIN-IMMUNE SYSTEM complex | |||||||||
Function / homology | Function and homology information notochord cell development / notochord formation / lens fiber cell morphogenesis / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of lymphangiogenesis / axial mesoderm formation / ephrin receptor activity / pericyte cell differentiation / cAMP metabolic process / positive regulation of bicellular tight junction assembly ...notochord cell development / notochord formation / lens fiber cell morphogenesis / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of lymphangiogenesis / axial mesoderm formation / ephrin receptor activity / pericyte cell differentiation / cAMP metabolic process / positive regulation of bicellular tight junction assembly / regulation of blood vessel endothelial cell migration / leading edge membrane / negative regulation of chemokine production / bone remodeling / post-anal tail morphogenesis / response to growth factor / activation of GTPase activity / tight junction / regulation of lamellipodium assembly / EPH-Ephrin signaling / branching involved in mammary gland duct morphogenesis / neural tube development / RND1 GTPase cycle / RND2 GTPase cycle / RND3 GTPase cycle / mammary gland epithelial cell proliferation / RHOV GTPase cycle / EPHA-mediated growth cone collapse / growth factor binding / regulation of cell adhesion mediated by integrin / lamellipodium membrane / RHOU GTPase cycle / ephrin receptor signaling pathway / RHOG GTPase cycle / EPH-ephrin mediated repulsion of cells / RAC2 GTPase cycle / RAC3 GTPase cycle / vasculogenesis / regulation of angiogenesis / keratinocyte differentiation / transmembrane receptor protein tyrosine kinase activity / RAC1 GTPase cycle / regulation of ERK1 and ERK2 cascade / negative regulation of angiogenesis / osteoclast differentiation / cell chemotaxis / skeletal system development / molecular function activator activity / protein localization to plasma membrane / cell motility / positive regulation of protein localization to plasma membrane / receptor protein-tyrosine kinase / neuron differentiation / ruffle membrane / osteoblast differentiation / intrinsic apoptotic signaling pathway in response to DNA damage / cell migration / lamellipodium / virus receptor activity / receptor complex / cell adhesion / defense response to Gram-positive bacterium / positive regulation of cell migration / inflammatory response / cadherin binding / focal adhesion / cell surface / ATP binding / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.25 Å | |||||||||
Authors | Singer, A.U. / Bruce, H.A. / Blazer, L. / Adams, J.J. / Sicheri, F. / Sidhu, S.S. | |||||||||
Funding support | United States, 2items
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Citation | Journal: To be Published Title: Synthetic Antibodies targeting EPHA2 Induce Diverse Signaling-Competent Clusters with Differential Activation Authors: Adams, J.J. / Bruce, H.A. / Ploder, L. / Garcia, J. / Khutoreskaya, G. / Jarvik, N. / Costa, L.E. / Gorelik, M. / Pot, I. / Sicheri, F. / Blazer, L.L. / Singer, A.U. / Sidhu, S.S. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 8trv.cif.gz | 632.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb8trv.ent.gz | 469 KB | Display | PDB format |
PDBx/mmJSON format | 8trv.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 8trv_validation.pdf.gz | 5.2 MB | Display | wwPDB validaton report |
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Full document | 8trv_full_validation.pdf.gz | 5.2 MB | Display | |
Data in XML | 8trv_validation.xml.gz | 49.3 KB | Display | |
Data in CIF | 8trv_validation.cif.gz | 68.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tr/8trv ftp://data.pdbj.org/pub/pdb/validation_reports/tr/8trv | HTTPS FTP |
-Related structure data
Related structure data | 8tv1C 8tv2C 8tv5C 3fl7S 8trsS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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