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Structure paper

TitleSynthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation.
Journal, issue, pagesProtein Sci., Vol. 34, Page e70145-e70145, Year 2025
Publish dateJun 23, 2023 (structure data deposition date)
AuthorsAdams, J.J. / Bruce, H.A. / Subramania, S. / Ploder, L. / Garcia, J. / Pot, I. / Blazer, L.L. / Singer, A.U. / Sidhu, S.S.
External linksProtein Sci. / PubMed:40411427
MethodsX-ray diffraction
Resolution2.6 - 4.6 Å
Structure data

PDB-8t9b:
Structure of the CK variant of Fab F1 (FabC-F1) in complex with the C-terminal FN3 domain of EphA2
Method: X-RAY DIFFRACTION / Resolution: 4.2 Å

PDB-8trv:
Structure of the EphA2 LBDCRD bound to FabS1C_C1
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

PDB-8tv1:
Structure of the EphA2 LBDCRD bound to FabS1C_L1
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8tv2:
Structure of apo FabS1C_L1
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

PDB-8tv5:
Structure of the EphA2 LBDCRD bound to FabS1CE_L1 in a 2:1 (EphA2 to Fab) ratio
Method: X-RAY DIFFRACTION / Resolution: 4.6 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / enhanced crystallization / EphA2 binding / expressed protein / Fab / Complex / receptor clustering / SIGNALING PROTEIN/IMMUNE SYSTEM / Cell signalling / antibody / agonist / high affinity / clustering / activation / SIGNALING PROTEIN-IMMUNE SYSTEM complex / SIGNALING PROTEIN

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