- PDB-8tlz: Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Re... -
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Basic information
Entry
Database: PDB / ID: 8tlz
Title
Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys
Components
MHC class I polypeptide-related sequence A
Keywords
IMMUNE SYSTEM / modified MICA / ligand NKG2D
Function / homology
Function and homology information
immune response to tumor cell / natural killer cell lectin-like receptor binding / negative regulation of natural killer cell activation / negative regulation of natural killer cell mediated cytotoxicity / gamma-delta T cell activation / natural killer cell mediated cytotoxicity / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / T cell mediated cytotoxicity / positive regulation of T cell mediated cytotoxicity ...immune response to tumor cell / natural killer cell lectin-like receptor binding / negative regulation of natural killer cell activation / negative regulation of natural killer cell mediated cytotoxicity / gamma-delta T cell activation / natural killer cell mediated cytotoxicity / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / T cell mediated cytotoxicity / positive regulation of T cell mediated cytotoxicity / peptide antigen binding / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / response to heat / defense response to virus / killing of cells of another organism / defense response to bacterium / immune response / external side of plasma membrane / signaling receptor binding / DNA damage response / cell surface / extracellular space / plasma membrane / cytoplasm Similarity search - Function
Class I Histocompatibility antigen, domains alpha 1 and 2 / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold Similarity search - Domain/homology
Mass: 22144.814 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: MICA / Production host: Homo sapiens (human) / References: UniProt: Q29983