登録情報 | データベース: PDB / ID: 8tb5 |
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タイトル | TYK2 JH2 bound to Compound7 |
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要素 | Non-receptor tyrosine-protein kinase TYK2 |
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キーワード | SIGNALING PROTEIN / TYK2 / pseudokinase / azaindole |
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機能・相同性 | 機能・相同性情報
type III interferon-mediated signaling pathway / interleukin-10-mediated signaling pathway / interleukin-12 receptor complex / interleukin-23 receptor complex / Interleukin-23 signaling / type 1 angiotensin receptor binding / positive regulation of T-helper 17 type immune response / positive regulation of NK T cell proliferation / interleukin-12-mediated signaling pathway / Interleukin-12 signaling ...type III interferon-mediated signaling pathway / interleukin-10-mediated signaling pathway / interleukin-12 receptor complex / interleukin-23 receptor complex / Interleukin-23 signaling / type 1 angiotensin receptor binding / positive regulation of T-helper 17 type immune response / positive regulation of NK T cell proliferation / interleukin-12-mediated signaling pathway / Interleukin-12 signaling / Interleukin-27 signaling / IL-6-type cytokine receptor ligand interactions / Interleukin-35 Signalling / positive regulation of natural killer cell proliferation / growth hormone receptor binding / Other interleukin signaling / extrinsic component of plasma membrane / Interleukin-20 family signaling / type I interferon-mediated signaling pathway / Interleukin-6 signaling / MAPK3 (ERK1) activation / positive regulation of interleukin-17 production / Interleukin-10 signaling / extrinsic component of cytoplasmic side of plasma membrane / MAPK1 (ERK2) activation / cell surface receptor signaling pathway via JAK-STAT / Regulation of IFNA/IFNB signaling / growth hormone receptor signaling pathway via JAK-STAT / type II interferon-mediated signaling pathway / positive regulation of T cell proliferation / Signaling by CSF3 (G-CSF) / non-specific protein-tyrosine kinase / positive regulation of receptor signaling pathway via JAK-STAT / non-membrane spanning protein tyrosine kinase activity / Inactivation of CSF3 (G-CSF) signaling / Evasion by RSV of host interferon responses / cytoplasmic side of plasma membrane / cellular response to virus / cytokine-mediated signaling pathway / positive regulation of protein localization to nucleus / positive regulation of type II interferon production / Interferon alpha/beta signaling / Signaling by ALK fusions and activated point mutants / protein tyrosine kinase activity / Interleukin-4 and Interleukin-13 signaling / Potential therapeutics for SARS / cell differentiation / cytoskeleton / intracellular signal transduction / immune response / protein phosphorylation / SARS-CoV-2 activates/modulates innate and adaptive immune responses / extracellular exosome / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Tyrosine-protein kinase, non-receptor, TYK2, N-terminal / : / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain / FERM F2 acyl-CoA binding protein-like domain / FERM F1 ubiquitin-like domain / FERM superfamily, second domain ...Tyrosine-protein kinase, non-receptor, TYK2, N-terminal / : / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain / FERM F2 acyl-CoA binding protein-like domain / FERM F1 ubiquitin-like domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 ACETATE ION / Chem-ZOQ / Non-receptor tyrosine-protein kinase TYK2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.32 Å |
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データ登録者 | Argiriadi, M.A. / Van Epps, S.A. / Breinlinger, E.C. |
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資金援助 | 1件 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2023 タイトル: Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. 著者: Breinlinger, E. / Van Epps, S. / Friedman, M. / Argiriadi, M. / Chien, E. / Chhor, G. / Cowart, M. / Dunstan, T. / Graff, C. / Hardee, D. / Herold, J.M. / Little, A. / McCarthy, R. / ...著者: Breinlinger, E. / Van Epps, S. / Friedman, M. / Argiriadi, M. / Chien, E. / Chhor, G. / Cowart, M. / Dunstan, T. / Graff, C. / Hardee, D. / Herold, J.M. / Little, A. / McCarthy, R. / Parmentier, J. / Perham, M. / Qiu, W. / Schrimpf, M. / Vargo, T. / Webster, M.P. / Wu, F. / Bennett, D. / Edmunds, J. |
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履歴 | 登録 | 2023年6月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年10月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2023年11月8日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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