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-Structure paper
Title | Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 14335-14356, Year 2023 |
Publish date | Jun 28, 2023 (structure data deposition date) |
Authors | Breinlinger, E. / Van Epps, S. / Friedman, M. / Argiriadi, M. / Chien, E. / Chhor, G. / Cowart, M. / Dunstan, T. / Graff, C. / Hardee, D. ...Breinlinger, E. / Van Epps, S. / Friedman, M. / Argiriadi, M. / Chien, E. / Chhor, G. / Cowart, M. / Dunstan, T. / Graff, C. / Hardee, D. / Herold, J.M. / Little, A. / McCarthy, R. / Parmentier, J. / Perham, M. / Qiu, W. / Schrimpf, M. / Vargo, T. / Webster, M.P. / Wu, F. / Bennett, D. / Edmunds, J. |
External links | J. Med. Chem. / PubMed:37823891 |
Methods | X-ray diffraction |
Resolution | 1.96 - 2.32 Å |
Structure data | PDB-8tb5: PDB-8tb6: |
Chemicals | ChemComp-ACT: ChemComp-ZOQ: ChemComp-HOH: ChemComp-ZOI: |
Source |
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Keywords | SIGNALING PROTEIN / TYK2 / pseudokinase / azaindole |