PDB-8sic: Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) ...

ID or keywords:

Entry

Database: PDB / ID: 8sic

Title

Crystal structure of Epstein-Barr virus glycoprotein 350 (gp350) in complex with Cy137C02, a monoclonal antibody isolated from macaques immunized with a gp350 nanoparticle vaccine

Components

(Cy137C02 Fab ...) x 2
Envelope glycoprotein gp350

Keywords

VIRAL PROTEIN/IMMUNE SYSTEM / viral protein / envelope glycoprotein / monoclonal antibody / antiviral / immune system / macaques / Epstein-Barr virus / VIRAL PROTEIN-IMMUNE SYSTEM complex

Function / homology

Function and homology information

host cell membrane / receptor ligand activity / symbiont entry into host cell / virion membrane / membrane
Similarity search - Function

Biological species

Macaca fascicularis (crab-eating macaque)

Human herpesvirus 4 (Epstein-Barr virus)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.76 Å

Authors

Joyce, M.G. / Jensen, J.L. / Chen, W.H. / Kanekiyo, M.

Funding support

United States, 1items

Citation

Journal: Immunity / Year: 2025
Title: Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350.
Authors: Joyce, M.G. / Bu, W. / Chen, W.H. / Gillespie, R.A. / Andrews, S.F. / Wheatley, A.K. / Tsybovsky, Y. / Jensen, J.L. / Stephens, T. / Prabhakaran, M. / Fisher, B.E. / Narpala, S.R. / Bagchi, ...

History

Deposition	Apr 14, 2023	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Apr 17, 2024	Provider: repository / Type: Initial release
Revision 1.1	Nov 13, 2024	Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification
Revision 1.2	Feb 12, 2025	Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year
Revision 1.3	Feb 19, 2025	Group: Database references / Category: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title
Revision 1.4	Feb 26, 2025	Group: Database references / Category: citation / Item: _citation.journal_volume / _citation.page_first

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

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Validation report

Summary document	8sic_validation.pdf.gz	509.9 KB	Display	wwPDB validaton report
Full document	8sic_full_validation.pdf.gz	542.7 KB	Display
Data in XML	8sic_validation.xml.gz	61.3 KB	Display
Data in CIF	8sic_validation.cif.gz	83.1 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/si/8sic ftp://data.pdbj.org/pub/pdb/validation_reports/si/8sic	HTTPS FTP

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Related structure data

Related structure data	8sefC 8sgaC 8sggC 8sgnC 8sm0C 8sm1C C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#21 - Sep 2001 Antibodies similarity (1) #256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1)

Deposited unit

A: Cy137C02 Fab heavy chain

B: Cy137C02 Fab light chain

E: Envelope glycoprotein gp350

G: Envelope glycoprotein gp350

H: Cy137C02 Fab heavy chain

L: Cy137C02 Fab light chain

hetero molecules

191 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Cy137C02 Fab heavy chain

B: Cy137C02 Fab light chain

E: Envelope glycoprotein gp350

hetero molecules

defined by author
Evidence: gel filtration
95.3 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

G: Envelope glycoprotein gp350

H: Cy137C02 Fab heavy chain

L: Cy137C02 Fab light chain

hetero molecules

defined by author
95.6 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	69.047, 71.377, 395.083
Angle α, β, γ (deg.)	90.00, 90.00, 90.00
Int Tables number	18
Space group name H-M	P2₁22₁

Components on special symmetry positions

ID	Model	Components
1	1	G-620- HOH

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Antibody , 2 types, 4 molecules AHBL

#1: Antibody	Cy137C02 Fab heavy chain Mass: 23805.807 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Macaca fascicularis (crab-eating macaque) Cell line (production host): Expi293 / Production host: Homo sapiens (human)
#2: Antibody	Cy137C02 Fab light chain Mass: 22806.154 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Macaca fascicularis (crab-eating macaque) Cell line (production host): Expi293 / Production host: Homo sapiens (human)

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Protein / Sugars , 2 types, 19 molecules EG

#3: Protein

Envelope glycoprotein gp350 / Membrane antigen / MA

Mass: 46895.230 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Human herpesvirus 4 (Epstein-Barr virus)
Strain: strain B95-8 / Gene: BLLF1 / Cell line (production host): Expi293F / Production host:

Homo sapiens (human) / References: UniProt: P03200

#4: Sugar

ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE

Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 17
Source method: isolated from a genetically manipulated source
Formula: C₈H₁₅NO₆

Identifier	Type	Program
DGlcpNAcb	CONDENSED IUPAC CARBOHYDRATE SYMBOL	GMML 1.0
N-acetyl-b-D-glucopyranosamine	COMMON NAME	GMML 1.0
b-D-GlcpNAc	IUPAC CARBOHYDRATE SYMBOL	PDB-CARE 1.0
GlcNAc	SNFG CARBOHYDRATE SYMBOL	GMML 1.0

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Non-polymers , 2 types, 118 molecules

#5: Chemical	ChemComp-ZN / ZINC ION Mass: 65.409 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Formula: Zn
#6: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 116 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	N
Has protein modification	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.66 Å³/Da / Density % sol: 53.82 %
Crystal grow	Temperature: 291 K / Method: vapor diffusion, hanging drop Details: 18% PEG 8000, 0.22 M sodium acetate, 0.1 M sodium cacodylate pH 6.5

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: APS / Beamline: 24-ID-E / Wavelength: 0.9792 Å
Detector	Type: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Nov 18, 2017
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.9792 Å / Relative weight: 1
Reflection	Resolution: 2.76→71.43 Å / Num. obs: 51461 / % possible obs: 99.9 % / Redundancy: 8.3 % / R_merge(I) obs: 0.106 / Net I/σ(I): 15.5
Reflection shell	Resolution: 2.76→2.91 Å / R_merge(I) obs: 1.213 / Mean I/σ(I) obs: 2 / Num. unique obs: 2338

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Processing

Software

Name	Version	Classification
PHENIX	1.20.1_4487	refinement
HKL-2000		data reduction
HKL-2000		data scaling
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: in-house structure of gp350 in a complex with a receptor fragment

Resolution: 2.76→71.38 Å / SU ML: 0.53 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 32.69 / Stereochemistry target values: ML

	R_factor	Num. reflection	% reflection
R_free	0.2949	2611	5.07 %
R_work	0.2455	-	-
obs	0.248	51461	99.46 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL

Refinement step

Cycle: LAST / Resolution: 2.76→71.38 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	12965	0	141	116	13222

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.004	13435
X-RAY DIFFRACTION	f_angle_d	0.659	18353
X-RAY DIFFRACTION	f_dihedral_angle_d	7.748	1897
X-RAY DIFFRACTION	f_chiral_restr	0.05	2148
X-RAY DIFFRACTION	f_plane_restr	0.005	2338

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.76-2.81	0.4441	140	0.4413	2338	X-RAY DIFFRACTION	95
2.81-2.86	0.4394	147	0.4164	2560	X-RAY DIFFRACTION	100
2.86-2.92	0.4317	135	0.4063	2515	X-RAY DIFFRACTION	100
2.92-2.98	0.3928	134	0.3711	2540	X-RAY DIFFRACTION	100
2.98-3.05	0.3953	119	0.3455	2538	X-RAY DIFFRACTION	100
3.05-3.13	0.3856	149	0.3327	2538	X-RAY DIFFRACTION	100
3.13-3.21	0.3285	136	0.2994	2534	X-RAY DIFFRACTION	100
3.21-3.31	0.3742	157	0.2959	2559	X-RAY DIFFRACTION	100
3.31-3.41	0.3801	151	0.2877	2521	X-RAY DIFFRACTION	100
3.41-3.54	0.3956	144	0.313	2545	X-RAY DIFFRACTION	100
3.54-3.68	0.3718	130	0.314	2572	X-RAY DIFFRACTION	100
3.68-3.84	0.3349	122	0.2685	2585	X-RAY DIFFRACTION	100
3.84-4.05	0.311	131	0.2375	2574	X-RAY DIFFRACTION	100
4.05-4.3	0.2604	134	0.2153	2607	X-RAY DIFFRACTION	100
4.3-4.63	0.2549	129	0.1954	2576	X-RAY DIFFRACTION	100
4.63-5.1	0.2314	135	0.1797	2624	X-RAY DIFFRACTION	100
5.1-5.84	0.2622	135	0.2126	2645	X-RAY DIFFRACTION	100
5.84-7.35	0.2657	135	0.2278	2651	X-RAY DIFFRACTION	100
7.35-71.38	0.2127	148	0.1921	2828	X-RAY DIFFRACTION	99

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	2.4617	-0.2945	0.4104	4.0865	-0.2427	3.8517	-0.1299	-0.1407	-0.0288	0.2303	-0.0267	-0.0016	0.3733	0.3338	0.1938	0.8482	0.259	-0.0515	0.5158	-0.0725	0.4413	92.261	103.496	500.578
2	0.0461	1.0127	0.0659	1.0151	0.1804	6.4307	-0.1771	0.0036	0.0426	0.3752	-0.2295	-0.0383	0.3058	-0.2858	0.2848	0.7858	0.2263	-0.077	0.4698	-0.0586	0.5302	92.517	110.782	508.08
3	2.0335	-5.243	6.1572	7.466	-4.0649	3.7848	-1.5461	-2.8131	0.9511	3.9716	1.6736	1.0979	0.1619	-0.9067	0.2007	1.8116	0.1796	0.1555	0.9719	0.0016	1.2257	82.961	127.997	538.873
4	3.6559	-2.4238	-3.1315	3.9612	-1.174	7.3259	0.3309	0.7097	-0.857	0.0458	-0.0389	0.6728	0.7798	-1.799	-0.4202	1.9861	0.4375	-0.1197	-1.0127	0.127	0.5755	87.329	114.48	525.026
5	6.9856	1.7894	-0.2331	2.3928	1.4373	3.9217	-0.0972	-0.151	0.9811	0.2076	-0.0898	0.4127	-0.2473	-0.5191	0.3203	1.2386	0.259	-0.0204	0.5253	0.0009	0.5469	86.706	119.221	529.196
6	4.5237	-2.4505	-0.8194	1.4052	0.8641	2.7959	-0.3361	-0.496	-0.8701	-0.2962	0.5378	0.7562	1.0739	-0.2894	0.1862	1.7108	-0.002	0.0406	0.5207	-0.0413	0.8511	84.603	110.853	533.231
7	1.3231	0.1186	-2.0018	5.4162	2.1168	7.2394	-0.0968	0.1455	0.2922	-0.3969	0.1641	0.0872	-0.2804	0.1156	-0.0591	0.9172	0.1618	-0.1663	0.4971	-0.0035	0.469	94.644	126.154	494.454
8	1.4946	1.1846	-1.4691	1.7131	1.0199	5.0741	0.2229	-0.1666	0.0633	0.4639	0.0441	0.3465	-0.6224	-0.7132	-0.0549	0.8367	-0.0321	-0.183	0.459	-0.0561	0.6183	93.799	126.679	529.917
9	2.737	0.3823	-0.2433	9.0226	1.462	5.9722	0.9642	0.1316	0.784	-0.3628	-0.7808	-0.4709	-0.201	0.6381	-0.1759	0.715	0.0096	0.1066	0.473	-0.0354	0.5859	99.547	132.873	530.189
10	2.0058	-1.6754	0.5281	5.6893	-0.0788	6.5447	0.1712	-0.3602	0.0789	-0.1374	0.1265	-0.4708	0.1765	0.1637	-0.187	0.7789	-0.0269	-0.0153	0.3887	-0.0335	0.6474	98.153	128.714	533.646
11	0.9723	-1.6793	-0.8435	2.7948	2.3191	5.3306	-0.125	0.1267	-0.0668	-0.0958	0.0437	-0.0709	-0.4472	0.1104	0.0893	0.5515	-0.1543	-0.0018	0.6378	-0.0314	0.5708	87.776	114.265	453.507
12	3.3806	-3.0126	1.3591	4.0053	-3.5498	4.4518	-0.0884	-0.6519	0.632	-0.5036	0.5744	-1.4208	-0.6783	0.8616	-0.1622	0.619	-0.1666	0.1369	1.0556	-0.2544	0.6756	100.017	114.488	455.365
13	2.0847	-0.3151	1.7109	3.3242	0.4491	4.469	-0.1237	-0.0069	0.3023	-0.0635	0.3143	-0.1072	-0.794	-0.0675	-0.2063	0.6194	-0.1558	-0.0268	0.6492	-0.0548	0.5513	89.252	116.221	461.835
14	4.6709	0.806	1.4545	5.9119	1.7344	5.98	-0.4594	-0.3245	-0.5423	1.0546	0.4986	0.5243	0.7699	-0.5779	0.0043	1.0421	0.0286	0.1379	0.7966	0.0333	0.5401	87.588	91.704	476.411
15	4.0997	2.0573	-0.7594	4.8113	0.4588	1.2508	-0.3818	0.0777	-0.3566	0.9586	0.2891	-0.1046	0.7584	0.0769	-0.0659	0.8873	0.0057	0.0559	0.6761	-0.0833	0.4909	88.619	94.426	472.292
16	-0.0716	-0.3773	1.3659	3.6405	3.0793	5.8411	-0.0883	0.103	-0.0601	-0.5906	0.1379	0.0871	-0.1261	-0.2423	-0.0611	0.6951	-0.1575	0.061	0.8446	0.0138	0.5041	86.052	100.607	430.149
17	-0.3701	0.3877	0.4173	3.0862	1.2989	4.4356	-0.1632	0.0384	-0.128	0.0551	0.2487	0.0605	0.5373	0.2308	-0.1502	0.2803	0.0114	0.0492	0.8419	-0.0476	0.7395	84.418	61.771	415.616
18	3.7424	-0.567	0.9772	2.5539	-0.4808	5.4507	0.165	-0.3421	-0.3653	-0.0704	-0.0721	-0.3591	0.8608	0.677	-0.2318	0.4177	0.1259	0.122	0.7572	-0.0447	0.6812	93.185	60.828	410.865
19	0.0432	0.1858	0.355	0.174	0.1995	8.3155	-0.0741	0.1074	-0.2027	-0.0355	0.1342	0.0411	0.6757	-0.125	-0.1696	0.3826	0.0274	0.0378	0.7927	-0.1217	0.747	84.507	61.188	405.773
20	4.4678	-2.6147	0.5933	4.935	0.8853	3.2967	-0.2254	-0.0182	0.32	-0.5707	0.2173	0.3751	-0.7222	-0.2065	-0.0134	0.5725	-0.0635	-0.0155	0.6953	-0.0189	0.5215	83.972	86.953	395.761
21	1.6503	1.2925	-1.276	3.0181	-0.8436	4.8112	-0.0639	0.1598	0.0433	-0.508	0.8411	-0.458	-0.7842	1.1124	-0.5833	0.3607	-0.1811	0.1631	0.7278	-0.1494	0.6019	90.383	79.268	400.052
22	0.4353	1.1446	-1.0408	4.8694	0.8637	5.3382	-0.0382	0.0941	-0.0215	0.3156	0.2266	-0.0544	-0.1392	0.1069	-0.1136	0.319	0.1041	0.0254	0.6496	0.0158	0.4894	84.114	74.653	441.785
23	-0.0161	-0.0577	-1.5412	-0.013	0.9436	7.2708	0.2142	-0.2973	0.0912	0.0881	-0.2667	0.2316	-0.3549	-0.3975	0.0973	0.4031	-0.132	0.0109	0.7938	-0.026	0.7034	86.608	71.071	366.435
24	7.0181	6.3008	-5.6027	6.4187	-6.2751	6.3653	-1.7994	2.8731	-0.8013	-4.2187	0.4419	-0.4754	1.2572	-0.0292	0.839	1.1218	-0.0348	0.1602	1.1352	-0.1578	1.0106	76.504	51.138	329.492
25	9.0465	1.8211	0.6525	8.707	1.4518	7.6305	0.0072	0.0289	0.1697	0.1155	-0.2189	0.7639	0.1379	-0.1016	0.2221	0.3278	0.0143	0.02	0.3439	0.0841	0.5276	78.642	62.548	339.434
26	6.0297	0.1093	2.1954	9.4673	1.4986	7.7445	0.4959	0.1012	-0.4805	-0.6939	0.1296	-0.3755	1.5197	0.1129	-0.2674	1.1454	-0.0141	-0.0072	0.6884	0.1126	0.7123	92.072	43.574	370.898
27	3.2959	-1.444	1.6038	1.8274	-1.0155	8.9286	0.0618	-0.224	0.4745	0.0785	-0.2224	0.0261	0.6868	0.1884	0.1704	0.5216	-0.1862	0.0437	0.6511	-0.0584	0.5406	87.708	54.559	375.906
28	0.5609	-1.5971	0.0263	3.9067	0.498	3.8293	0.1733	-0.2055	-0.1634	0.1717	-0.1581	0.2163	1.1547	-0.7774	-0.0204	0.8229	-0.4313	0.0489	0.8278	-0.0512	0.6739	86.772	50.384	374.771
29	2.345	0.6421	-0.0443	1.4842	2.2768	3.9527	0.2626	-0.1945	-0.0847	0.4817	-0.2356	0.2494	0.6496	-0.3328	0.1074	0.4455	-0.0156	0.079	0.3451	-0.0973	0.5351	84.879	49.021	340.993
30	3.6817	-3.1804	2.2787	6.0926	0.661	3.5701	0.2924	0.0068	-0.0745	0.7225	-0.327	-0.1211	0.4078	0.24	-0.06	0.393	-0.0728	-0.0587	0.419	-0.0922	0.5765	87.792	50.9	338.784
31	2.4461	1.588	-3.518	6.982	-3.7147	2.0078	-0.7959	0.2194	-0.1247	-0.3116	-0.7466	-3.2054	0.826	2.6322	1.0622	0.6081	0.1955	0.0246	0.6295	-0.0113	0.8351	96.814	46.881	331.093
32	6.1922	-0.603	-6.4848	8.845	1.8833	6.8291	0.545	-0.7567	1.3782	0.8756	0.6327	-1.9281	-0.2632	1.3796	-1.1994	0.5043	-0.0873	-0.0478	0.6902	0.0132	1.0226	95.013	53.02	341.434
33	3.3051	-0.1401	-1.5047	8.8766	-1.7041	4.7362	0.0524	0.0726	0.4983	-0.4353	-0.322	-0.6633	0.5603	0.6033	0.1064	0.4567	-0.0185	-0.0655	0.4007	-0.0407	0.623	90.066	49.136	335.283
34	5.295	3.2415	-2.6254	6.1938	-4.0034	2.6869	-0.2332	1.0141	-0.4385	-1.6585	0.7507	-1.2766	1.0056	-2.0998	-0.5056	0.703	0.0606	0.0042	1.0091	-0.0398	0.78	86.133	48.225	324.121

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	( CHAIN A AND RESID 1:83 )	A	1 - 83
2	X-RAY DIFFRACTION	2	( CHAIN A AND RESID 84:126 )	A	84 - 126
3	X-RAY DIFFRACTION	3	( CHAIN A AND RESID 127:141 )	A	127 - 141
4	X-RAY DIFFRACTION	4	( CHAIN A AND RESID 142:161 )	A	142 - 161
5	X-RAY DIFFRACTION	5	( CHAIN A AND RESID 162:200 )	A	162 - 200
6	X-RAY DIFFRACTION	6	( CHAIN A AND RESID 201:215 )	A	201 - 215
7	X-RAY DIFFRACTION	7	( CHAIN B AND RESID 1:102 )	B	1 - 102
8	X-RAY DIFFRACTION	8	( CHAIN B AND RESID 103:134 )	B	103 - 134
9	X-RAY DIFFRACTION	9	( CHAIN B AND RESID 135:155 )	B	135 - 155
10	X-RAY DIFFRACTION	10	( CHAIN B AND RESID 156:210 )	B	156 - 210
11	X-RAY DIFFRACTION	11	( CHAIN E AND RESID 6:68 )	E	6 - 68
12	X-RAY DIFFRACTION	12	( CHAIN E AND RESID 69:88 )	E	69 - 88
13	X-RAY DIFFRACTION	13	( CHAIN E AND RESID 89:162 )	E	89 - 162
14	X-RAY DIFFRACTION	14	( CHAIN E AND RESID 163:223 )	E	163 - 223
15	X-RAY DIFFRACTION	15	( CHAIN E AND RESID 224:305 )	E	224 - 305
16	X-RAY DIFFRACTION	16	( CHAIN E AND RESID 306:429 )	E	306 - 429
17	X-RAY DIFFRACTION	17	( CHAIN G AND RESID 7:64 )	G	7 - 64
18	X-RAY DIFFRACTION	18	( CHAIN G AND RESID 65:117 )	G	65 - 117
19	X-RAY DIFFRACTION	19	( CHAIN G AND RESID 118:166 )	G	118 - 166
20	X-RAY DIFFRACTION	20	( CHAIN G AND RESID 167:267 )	G	167 - 267
21	X-RAY DIFFRACTION	21	( CHAIN G AND RESID 268:317 )	G	268 - 317
22	X-RAY DIFFRACTION	22	( CHAIN G AND RESID 318:428 )	G	318 - 428
23	X-RAY DIFFRACTION	23	( CHAIN H AND RESID 1:126 )	H	1 - 126
24	X-RAY DIFFRACTION	24	( CHAIN H AND RESID 127:141 )	H	127 - 141
25	X-RAY DIFFRACTION	25	( CHAIN H AND RESID 142:214 )	H	142 - 214
26	X-RAY DIFFRACTION	26	( CHAIN L AND RESID 1:23 )	L	1 - 23
27	X-RAY DIFFRACTION	27	( CHAIN L AND RESID 24:50 )	L	24 - 50
28	X-RAY DIFFRACTION	28	( CHAIN L AND RESID 51:102 )	L	51 - 102
29	X-RAY DIFFRACTION	29	( CHAIN L AND RESID 103:126 )	L	103 - 126
30	X-RAY DIFFRACTION	30	( CHAIN L AND RESID 127:144 )	L	127 - 144
31	X-RAY DIFFRACTION	31	( CHAIN L AND RESID 145:155 )	L	145 - 155
32	X-RAY DIFFRACTION	32	( CHAIN L AND RESID 156:165 )	L	156 - 165
33	X-RAY DIFFRACTION	33	( CHAIN L AND RESID 166:202 )	L	166 - 202
34	X-RAY DIFFRACTION	34	( CHAIN L AND RESID 203:210 )	L	203 - 210

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