Entry | Database: PDB / ID: 8s9k |
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Title | Structure of dimeric FAM111A SPD S541A Mutant |
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Components | Serine protease FAM111A |
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Keywords | HYDROLASE / protease |
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Function / homology | Function and homology information
protein-DNA covalent cross-linking repair / negative regulation of viral genome replication / replication fork processing / protein autoprocessing / Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases / fibrillar center / peptidase activity / single-stranded DNA binding / DNA replication / DNA damage response ...protein-DNA covalent cross-linking repair / negative regulation of viral genome replication / replication fork processing / protein autoprocessing / Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases / fibrillar center / peptidase activity / single-stranded DNA binding / DNA replication / DNA damage response / chromatin / proteolysis / nucleoplasm / nucleus / cytoplasmSimilarity search - Function |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.72 Å |
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Authors | Palani, S. / Alvey, J.A. / Cong, A.T.Q. / Schellenberg, M.J. / Machida, Y. |
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Funding support | United States, 2items Organization | Grant number | Country |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | CA233700 | United States | National Institutes of Health/National Cancer Institute (NIH/NCI) | ZIA BC 012086 | United States |
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Citation | Journal: Nat Commun / Year: 2024 Title: Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes. Authors: Palani, S. / Machida, Y. / Alvey, J.R. / Mishra, V. / Welter, A.L. / Cui, G. / Bragantini, B. / Botuyan, M.V. / Cong, A.T.Q. / Mer, G. / Schellenberg, M.J. / Machida, Y.J. |
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History | Deposition | Mar 29, 2023 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Mar 20, 2024 | Provider: repository / Type: Initial release |
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