Entry Database : PDB / ID : 8qzz Structure visualization Downloads & linksTitle Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452 ComponentsEukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 3 Protein phosphatase 1 regulatory subunit 15A DetailsKeywords TRANSLATION / Eukaryotic Initiation Factor-2 / PP1 regulatory subunit / dephosphorylation / metabolismFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of translational initiation in response to stress / positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation / regulation of translational initiation by eIF2 alpha dephosphorylation / positive regulation of peptidyl-serine dephosphorylation / regulation of translation in response to endoplasmic reticulum stress / translation initiation ternary complex / protein phosphatase type 1 complex / glial limiting end-foot / response to kainic acid / Cellular response to mitochondrial stress ... positive regulation of translational initiation in response to stress / positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation / regulation of translational initiation by eIF2 alpha dephosphorylation / positive regulation of peptidyl-serine dephosphorylation / regulation of translation in response to endoplasmic reticulum stress / translation initiation ternary complex / protein phosphatase type 1 complex / glial limiting end-foot / response to kainic acid / Cellular response to mitochondrial stress / response to manganese-induced endoplasmic reticulum stress / positive regulation of type B pancreatic cell apoptotic process / methionyl-initiator methionine tRNA binding / negative regulation of translational initiation in response to stress / Response of EIF2AK1 (HRI) to heme deficiency / Recycling of eIF2:GDP / negative regulation of protein dephosphorylation / PERK-mediated unfolded protein response / PERK regulates gene expression / eukaryotic translation initiation factor 2 complex / regulation of translational initiation in response to stress / selenocysteine metabolic process / protein localization to endoplasmic reticulum / selenocysteine incorporation / protein-synthesizing GTPase / cytoplasmic translational initiation / translation factor activity, RNA binding / protein phosphatase regulator activity / protein phosphatase 1 binding / selenocysteine insertion sequence binding / formation of translation preinitiation complex / eukaryotic 48S preinitiation complex / Formation of the ternary complex, and subsequently, the 43S complex / Translation initiation complex formation / Ribosomal scanning and start codon recognition / negative regulation of phosphoprotein phosphatase activity / negative regulation of PERK-mediated unfolded protein response / protein phosphatase activator activity / positive regulation of phosphoprotein phosphatase activity / Response of EIF2AK4 (GCN2) to amino acid deficiency / L13a-mediated translational silencing of Ceruloplasmin expression / GTP hydrolysis and joining of the 60S ribosomal subunit / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / stress granule assembly / translational initiation / translation initiation factor activity / cellular response to amino acid starvation / response to endoplasmic reticulum stress / Downregulation of TGF-beta receptor signaling / ABC-family proteins mediated transport / PKR-mediated signaling / cytoplasmic stress granule / cellular response to UV / ribosome binding / cellular response to heat / cellular response to oxidative stress / mitochondrial outer membrane / regulation of cell cycle / cadherin binding / GTPase activity / apoptotic process / synapse / DNA damage response / endoplasmic reticulum membrane / GTP binding / protein kinase binding / Golgi apparatus / endoplasmic reticulum / mitochondrion / RNA binding / extracellular exosome / membrane / nucleus / cytoplasm / cytosol Similarity search - Function Protein phosphatase 1, regulatory subunit 15A/B, C-terminal / Phosphatase-1 catalytic subunit binding region / IF2a, S1-like domain / Translation initiation factor 2, alpha subunit / Translation initiation factor 2, alpha subunit, middle domain superfamily / Translation initiation factor 2, alpha subunit, C-terminal / Eukaryotic translation initiation factor 2 alpha subunit / Initiation factor eIF2 gamma, domain 2 / Initiation factor eIF2 gamma, GTP-binding domain / Initiation factor eIF2 gamma, C-terminal ... Protein phosphatase 1, regulatory subunit 15A/B, C-terminal / Phosphatase-1 catalytic subunit binding region / IF2a, S1-like domain / Translation initiation factor 2, alpha subunit / Translation initiation factor 2, alpha subunit, middle domain superfamily / Translation initiation factor 2, alpha subunit, C-terminal / Eukaryotic translation initiation factor 2 alpha subunit / Initiation factor eIF2 gamma, domain 2 / Initiation factor eIF2 gamma, GTP-binding domain / Initiation factor eIF2 gamma, C-terminal / Initiation factor eIF2 gamma, C terminal / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / S1 domain profile. / Translation elongation factor EFTu-like, domain 2 / Ribosomal protein S1-like RNA-binding domain / Elongation factor Tu domain 2 / S1 RNA binding domain / S1 domain / Translational (tr)-type GTP-binding domain / Elongation factor Tu GTP binding domain / Translational (tr)-type guanine nucleotide-binding (G) domain profile. / Translation protein, beta-barrel domain superfamily / Nucleic acid-binding, OB-fold / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homology PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / Protein phosphatase 1 regulatory subunit 15A / Eukaryotic translation initiation factor 2 subunit 1 / Eukaryotic translation initiation factor 2 subunit 3 Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.35 Å DetailsAuthors Yan, Y. / Ron, D. Funding support United Kingdom, 1items Details Hide detailsOrganization Grant number Country Wellcome Trust SGAG/182 United Kingdom
CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2024Title : Substrate recruitment via eIF2 gamma enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.Authors : Yan, Y. / Shetty, M. / Harding, H.P. / George, G. / Zyryanova, A. / Labbe, K. / Mafi, A. / Hao, Q. / Sidrauski, C. / Ron, D. History Deposition Oct 30, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 20, 2024 Provider : repository / Type : Initial releaseRevision 1.1 Apr 10, 2024 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
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