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Structure paper

TitleSubstrate recruitment via eIF2 gamma enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 121, Page e2320013121-e2320013121, Year 2024
Publish dateOct 30, 2023 (structure data deposition date)
AuthorsYan, Y. / Shetty, M. / Harding, H.P. / George, G. / Zyryanova, A. / Labbe, K. / Mafi, A. / Hao, Q. / Sidrauski, C. / Ron, D.
External linksProc. Natl. Acad. Sci. USA / PubMed:38547060
MethodsX-ray diffraction
Resolution3.35 Å
Structure data

PDB-8qzz:
Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452
Method: X-RAY DIFFRACTION / Resolution: 3.35 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

Source
  • homo sapiens (human)
KeywordsTRANSLATION / Eukaryotic Initiation Factor-2 / PP1 regulatory subunit / dephosphorylation / metabolism

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