Entry | Database: PDB / ID: 8qzd |
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Title | Soluble epoxide hydrolase in complex with Epoxykinin |
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Components | Bifunctional epoxide hydrolase 2 |
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Keywords | HYDROLASE / COMPLEX / STRUCTURAL GENOMICS / STRUCTURAL GENOMICS CONSORTIUM / SGC |
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Function / homology | Function and homology information
lipid-phosphate phosphatase / 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity / stilbene catabolic process / Biosynthesis of maresins / phospholipid dephosphorylation / soluble epoxide hydrolase / epoxide metabolic process / lipid phosphatase activity / lysophosphatidic acid phosphatase activity / Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ...lipid-phosphate phosphatase / 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity / stilbene catabolic process / Biosynthesis of maresins / phospholipid dephosphorylation / soluble epoxide hydrolase / epoxide metabolic process / lipid phosphatase activity / lysophosphatidic acid phosphatase activity / Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) / epoxide hydrolase activity / regulation of cholesterol metabolic process / phosphatase activity / peroxisomal matrix / toxic substance binding / dephosphorylation / cholesterol homeostasis / Peroxisomal protein import / response to toxic substance / peroxisome / positive regulation of gene expression / magnesium ion binding / protein homodimerization activity / extracellular exosome / cytosolSimilarity search - Function Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal / Phosphoglycolate phosphatase-like, domain 2 / HAD hydrolase, subfamily IA / Epoxide hydrolase-like / alpha/beta hydrolase fold / haloacid dehalogenase-like hydrolase / Alpha/beta hydrolase fold-1 / HAD superfamily / HAD-like superfamily / Alpha/Beta hydrolase foldSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.3 Å |
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Authors | Kumar, A. / Ehrler, J.M.H. / Ziegler, S. / Doetsch, L. / Proschak, E. / Knapp, S. / Structural Genomics Consortium (SGC) |
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Funding support | European Union, Switzerland, 3items Organization | Grant number | Country |
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European Union (EU) | EFRE-0200481 | European Union | Innovative Medicines Initiative | 115489 | Switzerland | European Communitys Seventh Framework Programme | FP7/2007-2013 | European Union |
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Citation | Journal: J.Med.Chem. / Year: 2024 Title: Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. Authors: Dotsch, L. / Davies, C. / Hennes, E. / Schonfeld, J. / Kumar, A. / Guita, C.D.C.L. / Ehrler, J.H.M. / Hiesinger, K. / Thavam, S. / Janning, P. / Sievers, S. / Knapp, S. / Proschak, E. / ...Authors: Dotsch, L. / Davies, C. / Hennes, E. / Schonfeld, J. / Kumar, A. / Guita, C.D.C.L. / Ehrler, J.H.M. / Hiesinger, K. / Thavam, S. / Janning, P. / Sievers, S. / Knapp, S. / Proschak, E. / Ziegler, S. / Waldmann, H. |
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History | Deposition | Oct 27, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Feb 28, 2024 | Provider: repository / Type: Initial release |
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Revision 1.1 | Apr 3, 2024 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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