Entry | Database: PDB / ID: 8qk5 |
---|
Title | Structure of K. pneumoniae LpxH in complex with EBL-3647 |
---|
Components | UDP-2,3-diacylglucosamine hydrolase |
---|
Keywords | HYDROLASE / Lipid A biosynthesis pathway Endotoxin UDP-diacyl-glucosamine Lipid X Gram-negative bacteria Lipopolysaccharides |
---|
Function / homology | Function and homology information
UDP-2,3-diacylglucosamine diphosphatase / UDP-2,3-diacylglucosamine hydrolase activity / lipid A biosynthetic process / extrinsic component of plasma membrane / manganese ion binding / cytoplasmSimilarity search - Function UDP-2,3-diacylglucosamine hydrolase / UDP-2,3-diacylglucosamine hydrolase LpxH-like / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-likeSimilarity search - Domain/homology |
---|
Biological species | Klebsiella pneumoniae (bacteria) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.95 Å |
---|
Authors | Sooriyaarachchi, S. / Bergfors, T. / Jones, T.A. / Mowbray, S.L. |
---|
Funding support | Sweden, 1items Organization | Grant number | Country |
---|
Swedish Research Council | | Sweden |
|
---|
Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2024 Title: Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Authors: Huseby, D.L. / Cao, S. / Zamaratski, E. / Sooriyaarachchi, S. / Ahmad, S. / Bergfors, T. / Krasnova, L. / Pelss, J. / Ikaunieks, M. / Loza, E. / Katkevics, M. / Bobileva, O. / Cirule, H. / ...Authors: Huseby, D.L. / Cao, S. / Zamaratski, E. / Sooriyaarachchi, S. / Ahmad, S. / Bergfors, T. / Krasnova, L. / Pelss, J. / Ikaunieks, M. / Loza, E. / Katkevics, M. / Bobileva, O. / Cirule, H. / Gukalova, B. / Grinberga, S. / Backlund, M. / Simoff, I. / Leber, A.T. / Berruga-Fernandez, T. / Antonov, D. / Konda, V.R. / Lindstrom, S. / Olanders, G. / Brandt, P. / Baranczewski, P. / Vingsbo Lundberg, C. / Liepinsh, E. / Suna, E. / Jones, T.A. / Mowbray, S.L. / Hughes, D. / Karlen, A. |
---|
History | Deposition | Sep 14, 2023 | Deposition site: PDBE / Processing site: PDBE |
---|
Revision 1.0 | Apr 17, 2024 | Provider: repository / Type: Initial release |
---|
|
---|