Entry Database : PDB / ID : 8pj7 Structure visualization Downloads & linksTitle MLLT3 in complex with compound PFI-6 ComponentsProtein AF-9 Details Keywords PEPTIDE BINDING PROTEIN / complex inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
modification-dependent protein binding / regulation of stem cell division / segment specification / regulation of chromatin organization / positive regulation of Wnt signaling pathway, planar cell polarity pathway / anterior/posterior pattern specification / hematopoietic stem cell differentiation / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / RNA Polymerase II Pre-transcription Events ... modification-dependent protein binding / regulation of stem cell division / segment specification / regulation of chromatin organization / positive regulation of Wnt signaling pathway, planar cell polarity pathway / anterior/posterior pattern specification / hematopoietic stem cell differentiation / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / RNA Polymerase II Pre-transcription Events / transcription elongation factor complex / lysine-acetylated histone binding / negative regulation of canonical Wnt signaling pathway / chromosome / gene expression / histone binding / molecular adaptor activity / chromatin binding / positive regulation of DNA-templated transcription / DNA binding / extracellular exosome / nucleoplasm / nucleus / cytosol Similarity search - FunctionBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.26 Å DetailsAuthors Raux, B. / Diaz-Saez, L. / Huber, K.V.M. / Fedorov, O. / Owen, D.R. / Londregan, A.T. / Bountra, C. / Edwards, A. / Arrowsmith, C. Funding support Switzerland, 1items Details Hide detailsOrganization Grant number Country Innovative Medicines Initiative 875510 Switzerland
CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2023Title : Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.Authors: Raux, B. / Buchan, K.A. / Bennett, J. / Christott, T. / Dowling, M.S. / Farnie, G. / Fedorov, O. / Gamble, V. / Gileadi, C. / Giroud, C. / Huber, K.V.M. / Korczynska, M. / Limberakis, C. / ... Authors : Raux, B. / Buchan, K.A. / Bennett, J. / Christott, T. / Dowling, M.S. / Farnie, G. / Fedorov, O. / Gamble, V. / Gileadi, C. / Giroud, C. / Huber, K.V.M. / Korczynska, M. / Limberakis, C. / Narayanan, A. / Owen, D.R. / Saez, L.D. / Stock, I.A. / Londregan, A.T. History Deposition Jun 22, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 22, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Dec 27, 2023 Group : Database references / Category : citation / Item : _citation.journal_volume
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