Entry | Database: PDB / ID: 8pji |
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Title | MLLT1 in complex with compound 10a |
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Components | Protein ENL |
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Keywords | PEPTIDE BINDING PROTEIN / complex inhibitor |
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Function / homology | Function and homology information
RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / RNA Polymerase II Pre-transcription Events / transcription elongation factor complex / lysine-acetylated histone binding / fibrillar center / chromatin binding / positive regulation of DNA-templated transcription / nucleoplasm / cytosolSimilarity search - Function |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.7 Å |
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Authors | Raux, B. / Diaz-Saez, L. / Huber, K.V.M. / Fedorov, O. / Owen, D.R. / Londregan, A.T. / Bountra, C. / Edwards, A. / Arrowsmith, C. |
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Funding support | Switzerland, 1items Organization | Grant number | Country |
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Innovative Medicines Initiative | 875510 | Switzerland |
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Citation | Journal: Bioorg.Med.Chem.Lett. / Year: 2023 Title: Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Authors: Raux, B. / Buchan, K.A. / Bennett, J. / Christott, T. / Dowling, M.S. / Farnie, G. / Fedorov, O. / Gamble, V. / Gileadi, C. / Giroud, C. / Huber, K.V.M. / Korczynska, M. / Limberakis, C. / ...Authors: Raux, B. / Buchan, K.A. / Bennett, J. / Christott, T. / Dowling, M.S. / Farnie, G. / Fedorov, O. / Gamble, V. / Gileadi, C. / Giroud, C. / Huber, K.V.M. / Korczynska, M. / Limberakis, C. / Narayanan, A. / Owen, D.R. / Saez, L.D. / Stock, I.A. / Londregan, A.T. |
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History | Deposition | Jun 23, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 22, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 27, 2023 | Group: Database references / Category: citation / Item: _citation.journal_volume |
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