登録情報 | データベース: PDB / ID: 8p1v |
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タイトル | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric compound 2 |
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要素 | S-adenosylmethionine synthase isoform type-2 |
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キーワード | TRANSFERASE / METHIONINE ADENOSYLTRANSFERASE / S-ADENOSYLMETHIONINE SYNTHASE ISOFORM 2 TYPE-2 / SAM / ALLOSTERIC INHIBITOR |
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機能・相同性 | 機能・相同性情報
methionine adenosyltransferase complex / methionine adenosyltransferase / methionine adenosyltransferase activity / cellular response to methionine / Methylation / S-adenosylmethionine biosynthetic process / protein heterooligomerization / protein hexamerization / small molecule binding / positive regulation of TORC1 signaling ...methionine adenosyltransferase complex / methionine adenosyltransferase / methionine adenosyltransferase activity / cellular response to methionine / Methylation / S-adenosylmethionine biosynthetic process / protein heterooligomerization / protein hexamerization / small molecule binding / positive regulation of TORC1 signaling / cellular response to leukemia inhibitory factor / one-carbon metabolic process / ATP binding / identical protein binding / metal ion binding / cytosol類似検索 - 分子機能 S-adenosylmethionine synthetase / S-adenosylmethionine synthetase, N-terminal / S-adenosylmethionine synthetase, central domain / S-adenosylmethionine synthetase, C-terminal / S-adenosylmethionine synthetase, conserved site / S-adenosylmethionine synthetase superfamily / S-adenosylmethionine synthetase, N-terminal domain / S-adenosylmethionine synthetase, central domain / S-adenosylmethionine synthetase, C-terminal domain / S-adenosylmethionine synthase signature 1. / S-adenosylmethionine synthase signature 2.類似検索 - ドメイン・相同性 S-ADENOSYLMETHIONINE / Chem-WIV / S-adenosylmethionine synthase isoform type-2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.54 Å |
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データ登録者 | Thomsen, M. / Thieulin-Pardo, G. / Neumann, L. |
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資金援助 | 1件 |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2023 タイトル: Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. 著者: Kalliokoski, T. / Kettunen, H. / Kumpulainen, E. / Kettunen, E. / Thieulin-Pardo, G. / Neumann, L. / Thomsen, M. / Paul, R. / Malyutina, A. / Georgiadou, M. |
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履歴 | 登録 | 2023年5月12日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年8月30日 | Provider: repository / タイプ: Initial release |
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