登録情報 データベース : PDB / ID : 8jyg 構造の表示 ダウンロードとリンクタイトル Crystal structure of Human HPSE1 in complex with inhibitor 要素Heparanase Heparanase 50 kDa subunit 詳細キーワード HYDROLASE/INHIBITOR / Endo-glucoronidase / Heparanase-1 / HEP / HPA / HPA1 / HPR1 / HPSE1 / HSE1 / HYDROLASE / HYDROLASE-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
heparanase / heparanase activity / regulation of hair follicle development / heparin metabolic process / proteoglycan metabolic process / heparan sulfate proteoglycan catabolic process / beta-glucuronidase activity / positive regulation of hair follicle development / HS-GAG degradation / syndecan binding ... heparanase / heparanase activity / regulation of hair follicle development / heparin metabolic process / proteoglycan metabolic process / heparan sulfate proteoglycan catabolic process / beta-glucuronidase activity / positive regulation of hair follicle development / HS-GAG degradation / syndecan binding / protein transmembrane transport / vascular wound healing / angiogenesis involved in wound healing / establishment of endothelial barrier / positive regulation of osteoblast proliferation / positive regulation of vascular endothelial growth factor production / positive regulation of blood coagulation / lysosomal lumen / extracellular matrix / cell-matrix adhesion / : / specific granule lumen / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / lysosome / membrane raft / lysosomal membrane / intracellular membrane-bounded organelle / Neutrophil degranulation / extracellular space / extracellular region / nucleoplasm / nucleus 類似検索 - 分子機能 Glycoside hydrolase, family 79 / Glycosyl hydrolase family 79, N-terminal domain / Glycoside hydrolase superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Mima, M. / Fujimoto, N. / Imai, Y. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : Bioorg.Med.Chem. / 年 : 2023タイトル : Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.著者: Imai, Y. / Suzuki, R. / Wakasugi, D. / Matsuda, D. / Tanaka-Yamamoto, N. / Ohki, Y. / Mima, M. / Endo, M. / Tabata, R. / Matsuzawa, H. / Hasegawa, Y. / Kato, S. / Sugisaki, M. / Miyagawa, H. ... 著者 : Imai, Y. / Suzuki, R. / Wakasugi, D. / Matsuda, D. / Tanaka-Yamamoto, N. / Ohki, Y. / Mima, M. / Endo, M. / Tabata, R. / Matsuzawa, H. / Hasegawa, Y. / Kato, S. / Sugisaki, M. / Miyagawa, H. / Fujimoto, N. / Fukunaga, T. / Kato, S. / Takahashi, T. / Kakinuma, H. 履歴 登録 2023年7月3日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2023年9月20日 Provider : repository / タイプ : Initial release