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Title | Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 93, Page 117460-117460, Year 2023 |
Publish date | Jul 3, 2023 (structure data deposition date) |
Authors | Imai, Y. / Suzuki, R. / Wakasugi, D. / Matsuda, D. / Tanaka-Yamamoto, N. / Ohki, Y. / Mima, M. / Endo, M. / Tabata, R. / Matsuzawa, H. ...Imai, Y. / Suzuki, R. / Wakasugi, D. / Matsuda, D. / Tanaka-Yamamoto, N. / Ohki, Y. / Mima, M. / Endo, M. / Tabata, R. / Matsuzawa, H. / Hasegawa, Y. / Kato, S. / Sugisaki, M. / Miyagawa, H. / Fujimoto, N. / Fukunaga, T. / Takahashi, T. / Kakinuma, H. |
External links | Bioorg. Med. Chem. / PubMed:37660465 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-8jyg: |
Chemicals | ChemComp-V8R: ChemComp-EDO: ChemComp-NAG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/INHIBITOR / Endo-glucoronidase / Heparanase-1 / HEP / HPA / HPA1 / HPR1 / HPSE1 / HSE1 / HYDROLASE / HYDROLASE-INHIBITOR complex |