Entry | Database: PDB / ID: 8j6n |
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Title | Crystal structure of Cystathionine gamma-lyase in complex with compound 1 |
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Components | Cystathionine gamma-lyase |
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Keywords | LYASE |
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Function / homology | Function and homology information
cystathionine gamma-lyase / L-cystine L-cysteine-lyase (deaminating) / cystathionine gamma-lyase activity / cysteine biosynthetic process / L-cysteine desulfhydrase activity / transsulfuration / pyridoxal phosphate bindingSimilarity search - Function Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. / Cys/Met metabolism, pyridoxal phosphate-dependent enzyme / Cys/Met metabolism PLP-dependent enzyme / Pyridoxal phosphate-dependent transferase, small domain / Pyridoxal phosphate-dependent transferase, major domain / Pyridoxal phosphate-dependent transferaseSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Rattus norvegicus (Norway rat) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.9 Å |
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Authors | Hibi, R. / Toma-Fukai, S. / Shimizu, T. / Hanaoka, K. |
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Funding support | Japan, 1items Organization | Grant number | Country |
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Japan Society for the Promotion of Science (JSPS) | | Japan |
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Citation | Journal: Sci Rep / Year: 2023 Title: Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Authors: Echizen, H. / Hanaoka, K. / Shimamoto, K. / Hibi, R. / Toma-Fukai, S. / Ohno, H. / Sasaki, E. / Komatsu, T. / Ueno, T. / Tsuchiya, Y. / Watanabe, Y. / Otsuka, T. / Saito, H. / Nagatoishi, S. ...Authors: Echizen, H. / Hanaoka, K. / Shimamoto, K. / Hibi, R. / Toma-Fukai, S. / Ohno, H. / Sasaki, E. / Komatsu, T. / Ueno, T. / Tsuchiya, Y. / Watanabe, Y. / Otsuka, T. / Saito, H. / Nagatoishi, S. / Tsumoto, K. / Kojima, H. / Okabe, T. / Shimizu, T. / Urano, Y. |
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History | Deposition | Apr 26, 2023 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Feb 14, 2024 | Provider: repository / Type: Initial release |
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