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TitleDiscovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.
Journal, issue, pagesSci Rep, Vol. 13, Page 16456-16456, Year 2023
Publish dateApr 26, 2023 (structure data deposition date)
AuthorsEchizen, H. / Hanaoka, K. / Shimamoto, K. / Hibi, R. / Toma-Fukai, S. / Ohno, H. / Sasaki, E. / Komatsu, T. / Ueno, T. / Tsuchiya, Y. ...Echizen, H. / Hanaoka, K. / Shimamoto, K. / Hibi, R. / Toma-Fukai, S. / Ohno, H. / Sasaki, E. / Komatsu, T. / Ueno, T. / Tsuchiya, Y. / Watanabe, Y. / Otsuka, T. / Saito, H. / Nagatoishi, S. / Tsumoto, K. / Kojima, H. / Okabe, T. / Shimizu, T. / Urano, Y.
External linksSci Rep / PubMed:37777556
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-8j6n:
Crystal structure of Cystathionine gamma-lyase in complex with compound 1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals


ChemComp, No image

ChemComp-TVJ:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsLYASE

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