Entry | Database: PDB / ID: 8iqj |
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Title | Crystal structure of SARS-CoV2 N-NTD |
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Components | Nucleoprotein |
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Keywords | VIRAL PROTEIN / nucleocapsid protein |
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Function / homology | Function and homology information
cytoplasmic capsid assembly / viral RNA genome packaging / response to host immune response / negative regulation of interferon-beta production / Maturation of nucleoprotein / intracellular non-membrane-bounded organelle / positive regulation of NLRP3 inflammasome complex assembly / MHC class I protein binding / CD28 dependent PI3K/Akt signaling / SARS-CoV-2 targets host intracellular signalling and regulatory pathways ...cytoplasmic capsid assembly / viral RNA genome packaging / response to host immune response / negative regulation of interferon-beta production / Maturation of nucleoprotein / intracellular non-membrane-bounded organelle / positive regulation of NLRP3 inflammasome complex assembly / MHC class I protein binding / CD28 dependent PI3K/Akt signaling / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / protein sequestering activity / VEGFR2 mediated vascular permeability / molecular condensate scaffold activity / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / DDX58/IFIH1-mediated induction of interferon-alpha/beta / MHC class I protein complex / Interleukin-1 signaling / RNA stem-loop binding / Interferon alpha/beta signaling / viral capsid / PIP3 activates AKT signaling / Transcription of SARS-CoV-2 sgRNAs / host cell endoplasmic reticulum-Golgi intermediate compartment / host cell Golgi apparatus / viral nucleocapsid / Translation of Structural Proteins / Virion Assembly and Release / host extracellular space / Induction of Cell-Cell Fusion / Attachment and Entry / host cell perinuclear region of cytoplasm / ribonucleoprotein complex / SARS-CoV-2 activates/modulates innate and adaptive immune responses / protein homodimerization activity / RNA binding / extracellular region / identical protein binding / cytoplasmSimilarity search - Function Nucleocapsid protein, betacoronavirus / Nucleocapsid (N) protein, C-terminal domain, coronavirus / Nucleocapsid (N) protein, N-terminal domain, coronavirus / Coronavirus nucleocapsid (CoV N) protein N-terminal (NTD) domain profile. / Coronavirus nucleocapsid (CoV N) protein C-terminal (CTD) domain profile. / Nucleocapsid protein, coronavirus / Nucleocapsid protein, C-terminal / Nucleocapsid protein, N-terminal / Coronavirus nucleocapsidSimilarity search - Domain/homology |
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Biological species | ![](img/tx_virus.gif) Severe acute respiratory syndrome coronavirus 2 |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.3 Å |
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Authors | Hong, J.Y. / Hou, M.H. |
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Funding support | Taiwan, 1items Organization | Grant number | Country |
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Ministry of Science and Technology (MoST, Taiwan) | 109-2327-B-005-005 | Taiwan |
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Citation | Journal: Biophys.J. / Year: 2024 Title: Targeting protein-protein interaction interfaces with antiviral N protein inhibitor in SARS-CoV-2. Authors: Hong, J.Y. / Lin, S.C. / Kehn-Hall, K. / Zhang, K.M. / Luo, S.Y. / Wu, H.Y. / Chang, S.Y. / Hou, M.H. |
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History | Deposition | Mar 16, 2023 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Feb 7, 2024 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 6, 2024 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
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