登録情報 データベース : PDB / ID : 8hq2 構造の表示 ダウンロードとリンクタイトル Crystal structure of human ADAM22 in complex with human LGI1 mutant 要素Disintegrin and metalloproteinase domain-containing protein 22 Leucine-rich glioma-inactivated protein 1 詳細キーワード MEMBRANE PROTEIN / SYNAPTIC MODULATOR / COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
LGI-ADAM interactions / axon initial segment / negative regulation of cell adhesion / neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of synaptic transmission / synaptic cleft / central nervous system development / axon guidance / postsynaptic density membrane / metalloendopeptidase activity ... LGI-ADAM interactions / axon initial segment / negative regulation of cell adhesion / neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of synaptic transmission / synaptic cleft / central nervous system development / axon guidance / postsynaptic density membrane / metalloendopeptidase activity / neuron projection development / integrin binding / nervous system development / positive regulation of cell growth / cell adhesion / axon / signaling receptor binding / glutamatergic synapse / dendrite / Golgi apparatus / endoplasmic reticulum / proteolysis / extracellular space / extracellular region / membrane / plasma membrane / cytoplasm 類似検索 - 分子機能 : / Leucine-rich glioma-inactivated , EPTP repeat / EAR / EPTP domain / EAR repeat profile. / ADAM cysteine-rich / ADAM, cysteine-rich domain / ADAM Cysteine-Rich Domain / Disintegrin, conserved site / Disintegrins signature. ... : / Leucine-rich glioma-inactivated , EPTP repeat / EAR / EPTP domain / EAR repeat profile. / ADAM cysteine-rich / ADAM, cysteine-rich domain / ADAM Cysteine-Rich Domain / Disintegrin, conserved site / Disintegrins signature. / Peptidase M12B, propeptide / Reprolysin family propeptide / Reprolysin domain, adamalysin-type / Reprolysin (M12B) family zinc metalloprotease / Disintegrin / Disintegrin domain profile. / Homologues of snake disintegrins / Disintegrin domain / Disintegrin domain superfamily / Peptidase M12B, ADAM/reprolysin / ADAM type metalloprotease domain profile. / EGF-like domain, extracellular / EGF-like domain / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Metallopeptidase, catalytic domain superfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / EGF-like domain signature 1. / Leucine-rich repeat / EGF-like domain / Leucine-rich repeat domain superfamily 類似検索 - ドメイン・相同性 Leucine-rich glioma-inactivated protein 1 / Disintegrin and metalloproteinase domain-containing protein 22 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.93 Å 詳細データ登録者 Liu, H. / Lin, Z. / Xu, F. 資金援助 中国, 1件 詳細 詳細を隠す組織 認可番号 国 National Science Foundation (NSF, China) 31270767 中国
引用ジャーナル : To Be Published タイトル : Crystal structure of human ADAM22 in complex with human LGI1 mutant著者 : Liu, H. / Lin, Z. / Xu, F. 履歴 登録 2022年12月13日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2023年12月13日 Provider : repository / タイプ : Initial release